Detailed analysis of metastatic colorectal cancer patients who developed cardiotoxicity on another fluoropyrimidine and switched to S-1 treatment (subgroup analysis of the CardioSwitch-study)

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Detailed analysis of metastatic colorectal cancer patients who developed cardiotoxicity on another fluoropyrimidine and switched to S-1 treatment (subgroup analysis of the CardioSwitch-study)

Kinos, Sampsa (författare): Tampere Univ Hosp, Tays Canc Ctr, Dept Oncol, Tampere, Finland.;Univ Tampere, Fac Med & Hlth Technol, Tampere, Finland.

Hagman, Helga (författare): Skane Univ Hosp, Dept Oncol, Malmö, Sweden.

Halonen, Päivi (författare): Helsinki Univ Hosp, Univ Helsinki, Helsinki, Finland.;Univ Helsinki, Helsinki, Finland.

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Soveri, Leena-Maija (författare): Helsinki Univ Hosp, Univ Helsinki, Helsinki, Finland.;Univ Helsinki, Helsinki, Finland.

O'Reilly, Mary (författare): St Vincents Univ Hosp, Dept Oncol, Dublin, Ireland.;Univ Coll Dublin, Dublin, Ireland.

Pfeiffer, Per (författare): Karolinska Institutet,Odense Univ Hosp, Dept Oncol, Odense, Denmark.

Frödin, Jan-Erik (författare): Karolinska Institutet,Karolinska Univ Hosp, Dept Oncol, Stockholm, Sweden.

Sorbye, Halfdan (författare): Univ Bergen, Haukeland Univ Hosp, NO-5021 Bergen, Norway.

Heervä, Eetu (författare): Turku Univ Hosp, Dept Oncol, Turku, Finland.;Univ Turku, Turku, Finland.

Liposits, Gabor (författare): Reg Hosp West Jutland, Dept Oncol, Herning, Denmark.

Kallio, Raija (författare): Oulu Univ, Dept Oncol, Oulu, Finland.;Univ Hosp Oulu, Oulu, Finland.

Ålgars, Annika (författare): Turku Univ Hosp, Dept Oncol, Turku, Finland.;Univ Turku, Turku, Finland.

Ristamäki, Raija (författare): Turku Univ Hosp, Dept Oncol, Turku, Finland.;Univ Turku, Turku, Finland.

Salminen, Tapio (författare): Tampere Univ Hosp, Tays Canc Ctr, Dept Oncol, Tampere, Finland.;Univ Tampere, Fac Med & Hlth Technol, Tampere, Finland.

Bärlund, Maarit (författare): Tampere Univ Hosp, Tays Canc Ctr, Dept Oncol, Tampere, Finland.;Univ Tampere, Fac Med & Hlth Technol, Tampere, Finland.

Shah, Carl-Henrik (författare): Karolinska Univ Hosp, Dept Oncol, Stockholm, Sweden.

Mcdermott, Ray (författare): St Vincents Univ Hosp, Dept Oncol, Dublin, Ireland.;Univ Coll Dublin, Dublin, Ireland.

Röckert, Rebecka (författare): Department of Oncology, Uppsala University Hospital, Uppsala, Sweden

Flygare, Petra (författare): Sundsvall Hosp, Dept Oncol, Sundsvall, Sweden.

Kwakman, Johannes (författare): Univ Med Ctr Utrecht, Utrecht Univ, Dept Med Oncol, Utrecht, Netherlands.

Teske, Arco (författare): Univ Med Ctr, Utrecht Univ, Dept Cardiol, Utrecht, Netherlands.

Punt, Cornelis (författare): Univ Utrecht, Univ Med Ctr Utrecht, Jules Ctr Hlth Sci & Primary Care, Dept Epidemiol, Utrecht, Netherlands.

Glimelius, Bengt (författare): Department of Oncology, Uppsala University Hospital, Uppsala, Sweden

Österlund, Pia (författare): Tampere Univ Hosp, Tays Canc Ctr, Dept Oncol, Tampere, Finland.;Univ Tampere, Fac Med & Hlth Technol, Tampere, Finland.;Helsinki Univ Hosp, Univ Helsinki, Helsinki, Finland.;Univ Helsinki, Helsinki, Finland.;Karolinska Inst, Dept Oncol & Pathol, Stockholm, Sweden.;Karolinska Univ Hosp, Dept GI Canc, Tema Canc, Stockholm, Sweden.

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Tampere Univ Hosp, Tays Canc Ctr, Dept Oncol, Tampere, Finland;Univ Tampere, Fac Med & Hlth Technol, Tampere, Finland. Skane Univ Hosp, Dept Oncol, Malmö, Sweden. (creator_code:org_t)

Medical Journals Sweden, 2024
2024
Engelska.
Ingår i: Acta Oncologica. - : Medical Journals Sweden. - 0284-186X .- 1651-226X. ; 63, s. 248-258

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Background and purpose: The CardioSwitch-study demonstrated that patients with solid tumors who develop cardiotoxicity on capecitabine or 5-fluorouracil (5-FU) treatment can be safely switched to S-1, an alternative fluoropyrimidine (FP). In light of the European Medicines Agency approval of S-1 in metastatic colorectal cancer (mCRC), this analysis provides more detailed safety and efficacy information, and data regarding metastasectomy and/or local ablative therapy (LAT), on the mCRC patients from the original study.Materials and methods: This retrospective cohort study was conducted at 12 European centers. The primary endpoint was recurrence of cardiotoxicity after switch. For this analysis, safety data are reported for 78 mCRC patients from the CardioSwitch cohort (N = 200). Detailed efficacy and outcomes data were available for 66 mCRC patients.Results: Data for the safety of S-1 in mCRC patients were similar to the original CardioSwitch cohort and that expected for FP-based treatment, with no new concerns. Recurrent cardiotoxicity (all grade 1) with S-1-based treatment occurred in 4/78 (5%) mCRC patients; all were able to complete FP treatment. Median progression-free survival from initiation of S-1-based treatment was 9.0 months and median overall survival 26.7 months. Metastasectomy and/or LAT was performed in 33/66 (50%) patients, and S-1 was successfully used in recommended neoadjuvant/conversion or adjuvant-like combination regimens and schedules as for standard FPs.Interpretation: S-1 is a safe and effective FP alternative when mCRC patients are forced to discontinue 5-FU or capecitabine due to cardiotoxicity and can be safely used in the standard recommended regimens, settings, and schedules.

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Detailed analysis of metastatic colorectal cancer patients who developed cardiotoxicity on another fluoropyrimidine and switched to S-1 treatment (subgroup analysis of the CardioSwitch-study)

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