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- Waagstein, Finn, 1938, et al.
(författare)
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Increased exercise ejection fraction and reversed remodeling after long-term treatment with metoprolol in congestive heart failure: a randomized, stratified, double-blind, placebo-controlled trial in mild to moderate heart failure due to ischemic or idiopathic dilated cardiomyopathy.
- 2003
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Ingår i: European journal of heart failure. - 1388-9842. ; 5:5, s. 679-91
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Tidskriftsartikel (refereegranskat)abstract
- the effects of long-term administration of beta-blockers on left ventricular (LV) function during exercise in patients with ischemic heart disease (IHD) and idiopathic dilated cardiomyopathy (DCM) are controversial.patients with stable congestive heart failure (CHF) (New York heart association [NYHA] class II and III) and ejection fraction (EF) < or =0.40 were randomized to metoprolol, 50 mg t.i.d. or placebo for 6 months. Patients were divided into two groups: ischemic heart disease (IHD) and idiopathic dilated cardiomyopathy (DCM). The mean EF was 0.29 in both groups and 92% were taking angiotensin-converting enzyme (ACE) inhibitors. In the IHD group, 84% had suffered a myocardial infarction (MI) and 64% had undergone revascularization at least 6 months before the study. LV volumes were measured by equilibrium radionuclide angiography. Mitral regurgitation was assessed by Doppler echocardiography. All values are changes for metoprolol subtracted by changes for placebo.metoprolol improved LV function markedly both at rest and during sub-maximal exercise in both groups. The mean increase in EF was 0.069 at rest (P<0.001) and 0.078 during submaximal exercise (P<0.001). LV end-diastolic volume decreased by 22 ml at rest (P=0.006) and by 15 ml during exercise (P=0.006). LV end-systolic volume decreased by 23 ml both at rest (P=0.001) and during exercise (P=0.004). Exercise time increased by 39 s (P=0.08). In the metoprolol group, mitral regurgitation decreased (P=0.0026) and only one patient developed atrial fibrillation vs. eight in the placebo group (P=0.01).metoprolol improves EF both at rest and during submaximal exercise and prevents LV dilatation in mild to moderate CHF due to IHD or DCM.
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| 2. |
- Holleboom, Thijs Jan, et al.
(författare)
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A Log Archiving System for Wide Area Networks
- 2004
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Konferensbidrag (refereegranskat)abstract
- Monitoring and maintaining modern Wide Area Networks is a complex and time consuming task. These are networks that are owned by different Internet Service Providers all over the world. The demands for accessibility grow hand in hand with theincreasing number of services and users. This makes effective troubleshooting more important than ever.There is an obvious lack of tools today to support the analysis of the state of these networks. This work is an attempt to make this analysis faster, more accurate, and to reduce the demands on the network technicians. Today a technician has to work his way through a huge amount of log data produced by the routers in the network. Finding the cause of the problems often requires great skill, experience, and intuition.The goal of this work is to speed up the process of nailing down the source of errors in the network. The basic approach is to store the data in a database. This allows for fast access, for the possibility of combining different methods of analysis, and for filtering out irrelevant information. Furthermore a databasealso allows for the possibility of presenting statistics and tracking faults over longer periods of time.
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