| 1. |
|
|
| 2. |
- Legendre, C. M., et al.
(författare)
-
Terminal Complement Inhibitor Eculizumab in Atypical Hemolytic-Uremic Syndrome
- 2013
-
Ingår i: New England Journal of Medicine. - 0028-4793 .- 1533-4406. ; 368:23, s. 2169-2181
-
Tidskriftsartikel (refereegranskat)abstract
- Background Atypical hemolytic-uremic syndrome is a genetic, life-threatening, chronic disease of complement-mediated thrombotic microangiopathy. Plasma exchange or infusion may transiently maintain normal levels of hematologic measures but does not treat the underlying systemic disease. Methods We conducted two prospective phase 2 trials in which patients with atypical hemolytic-uremic syndrome who were 12 years of age or older received eculizumab for 26 weeks and during long-term extension phases. Patients with low platelet counts and renal damage (in trial 1) and those with renal damage but no decrease in the platelet count of more than 25% for at least 8 weeks during plasma exchange or infusion (in trial 2) were recruited. The primary end points included a change in the platelet count (in trial 1) and thrombotic microangiopathy event-free status (no decrease in the platelet count of >25%, no plasma exchange or infusion, and no initiation of dialysis) (in trial 2). Results A total of 37 patients (17 in trial 1 and 20 in trial 2) received eculizumab for a median of 64 and 62 weeks, respectively. Eculizumab resulted in increases in the platelet count; in trial 1, the mean increase in the count from baseline to week 26 was 73x10(9) per liter (P<0.001). In trial 2, 80% of the patients had thrombotic microangiopathy event-free status. Eculizumab was associated with significant improvement in all secondary end points, with continuous, time-dependent increases in the estimated glomerular filtration rate (GFR). In trial 1, dialysis was discontinued in 4 of 5 patients. Earlier intervention with eculizumab was associated with significantly greater improvement in the estimated GFR. Eculizumab was also associated with improvement in health-related quality of life. No cumulative toxicity of therapy or serious infection-related adverse events, including meningococcal infections, were observed through the extension period. Conclusions Eculizumab inhibited complement-mediated thrombotic microangiopathy and was associated with significant time-dependent improvement in renal function in patients with atypical hemolytic-uremic syndrome.
|
|
| 3. |
- Prashanth, K.G., et al.
(författare)
-
Structural and Mechanical Characterization of Zr 58.5Ti 8.2Cu 14.2Ni 11.4Al 7.7 Bulk Metallic Glass
- 2012
-
Ingår i: Materials. - : MDPI AG. - 1996-1944. ; 5:1, s. 1-11
-
Tidskriftsartikel (refereegranskat)abstract
- Thermal stability, structure and mechanical properties of the multi-component Zr 58.5Ti 8.2Cu 14.2Ni 11.4Al 7.7 bulk metallic glass have been studied in detail. The glassy material displays good thermal stability against crystallization and a fairly large supercooled liquid region of 52 K. During heating, the alloy transforms into a metastable icosahedral quasicrystalline phase in the first stage of crystallization. At high temperatures, the quasicrystalline phase undergoes a transformation to form tetragonal and cubic NiZr 2-type phases. Room-temperature compression tests of the as-cast sample show good mechanical properties, namely, high compressive strength of about 1,630 MPa and fracture strain of 3.3%. This is combined with a density of 6.32 g/cm 3 and values of Poisson's ratio and Young's modulus of 0.377 and 77 GPa, respectively. The mechanical properties of the glass can be further improved by cold rolling. The compressive strength rises to 1,780 MPa and the fracture strain increases to 8.3% for the material cold-rolled to a diameter reduction of 10%.
|
|
| 4. |
- Schoenrock, A., et al.
(författare)
-
Efficient prediction of human protein-protein interactions at a global scale
- 2014
-
Ingår i: Bmc Bioinformatics. - : Springer Science and Business Media LLC. - 1471-2105. ; 15
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Our knowledge of global protein-protein interaction (PPI) networks in complex organisms such as humans is hindered by technical limitations of current methods. Results: On the basis of short co-occurring polypeptide regions, we developed a tool called MP-PIPE capable of predicting a global human PPI network within 3 months. With a recall of 23% at a precision of 82.1%, we predicted 172,132 putative PPIs. We demonstrate the usefulness of these predictions through a range of experiments. Conclusions: The speed and accuracy associated with MP-PIPE can make this a potential tool to study individual human PPI networks (from genomic sequences alone) for personalized medicine.
|
|
| 5. |
- Andersson, Joel Håkan, 1981, et al.
(författare)
-
Solidification of alloy 718, ati 718Plus® and waspaloy
- 2014
-
Ingår i: 8th International Symposium on Superalloy 718 and Derivatives 2014. - Hoboken, NJ, USA : John Wiley & Sons, Inc.. - 9781634396424 ; , s. 181-192
-
Konferensbidrag (refereegranskat)abstract
- Alloy 718, ATI 718Plus® and Waspaloy have been investigated in terms of what their respective solidification process reveals. Differential thermal analysis was used to approach the task together with secondary electron and back scattered electron detectors equipped with an energy dispersive X-ray spectroscopy detector. These experimental methods were used to construct pseudo binary phase diagrams that could aid in explaining solidification as well as liquation mechanisms in processes such as welding and casting. Furthermore, it was seen that Waspaloy has the smallest solidification range, followed by Alloy 718, and finally ATI 718Plus® possessing the largest solidification interval in comparison.
|
|
| 6. |
- Donnadieu, P., et al.
(författare)
-
Deformation at ambient and high temperature of in situ Laves phases-ferrite composites
- 2014
-
Ingår i: Science and Technology of Advanced Materials. - : Informa UK Limited. - 1468-6996 .- 1878-5514. ; 15:3
-
Tidskriftsartikel (refereegranskat)abstract
- The mechanical behavior of a Fe80Zr10Cr10 alloy has been studied at ambient and high temperature. This Fe 80Zr10Cr10 alloy, whoose microstructure is formed by alternate lamellae of Laves phase and ferrite, constitutes a very simple example of an in situ CMA phase composite. The role of the Laves phase type was investigated in a previous study while the present work focuses on the influence of the microstructure length scale owing to a series of alloys cast at different cooling rates that display microstructures with Laves phase lamellae width ranging from ∼50 nm to ∼150 nm. Room temperature compression tests have revealed a very high strength (up to 2 GPa) combined with a very high ductility (up to 35%). Both strength and ductility increase with reduction of the lamella width. High temperature compression tests have shown that a high strength (900 MPa) is maintained up to 873 K. Microstructural study of the deformed samples suggests that the confinement of dislocations in the ferrite lamellae is responsible for strengthening at both ambient and high temperature. The microstructure scale in addition to CMA phase structural features stands then as a key parameter for optimization of mechanical properties of CMA in situ composites. © 2014 National Institute for Materials Science.
|
|
| 7. |
- Mahmmoud Sayed, Abd El-sadek, et al.
(författare)
-
CdTe@Cu(OH)(2) nanocomposite: Aqueous synthesis and characterization
- 2011
-
Ingår i: Journal of Solid State Chemistry. - : Elsevier BV. - 0022-4596. ; 184:5, s. 1135-1140
-
Tidskriftsartikel (refereegranskat)abstract
- CdTe@Cu(OH)(2) nanocomposites were synthesized in aqueous solution by a seed-mediated growth approach. The effect of refluxing time and the concentration of Cu2+ on the preparation of these samples were measured using UV-visible absorption and photoluminescence analysis. The emission peak of the synthesized nanocomposites (CdTe@Cu(OH)(2)) was shifted from 605 (CdTe seed) to 621 nm. The size of CdTe nanoparticles were averaged about 3.22 nm, and the CdTe@Cu(OH)(2) nanocomposites were averaged as 5.19 nm. The synthesized CdTe@Cu(OH)(2) nanocomposite were characterized with XRD, EDAX, TEM, FT-IR, EPR, and thermal analysis (TG/DTG curves). The results indicate that as-prepared nanoparticles with core/shell structure exhibit interesting optical properties. (C) 2011 Elsevier Inc. All rights reserved.
|
|
| 8. |
- Mahmmoud Sayed, Abd El-sadek, et al.
(författare)
-
Influence of different stabilizers on the optical and nonlinear optical properties of CdTe nanoparticles
- 2011
-
Ingår i: Optics Communications. - : Elsevier BV. - 0030-4018. ; 284:12, s. 2900-2904
-
Tidskriftsartikel (refereegranskat)abstract
- CdTe semiconductor nanocrystals were synthesized with three different stabilizers: Mercaptoacetic Acid (MM), Mercaptopropionic Acid (MPA) and 2-Mercaptoethanol (ME) at pH approximate to 11.2 by wet chemical route using potassium tellurite and cadmium chloride as starting materials. The effect of capping agent on the preparation of these samples was evaluated using UV-Visible absorption and photoluminescence analysis. With the same reaction time but with different stabilizers, nanocrystals of different diameters were obtained. The average full width at half maximum of the photoluminescence spectra was about 69 nm which indicates that the monodispersity was quite good. The particle size was calculated by Debye-Scherrer equation from XRD data. Further characterization studies such as FT-IR and optical nonlinearity studies on the samples were carried out and the results are discussed. (C) 2011 Elsevier B.V. All rights reserved.
|
|
| 9. |
- Perumal, Rajagembu, et al.
(författare)
-
Nucleation kinetics and growth aspects of glycine phosphite ferroelectric single crystals
- 2011
-
Ingår i: Materials Chemistry and Physics. - : Elsevier BV. - 0254-0584 .- 1879-3312. ; 126:1-2, s. 381-385
-
Tidskriftsartikel (refereegranskat)abstract
- The nucleation parameters of glycine phosphite (GPI) ferroelectric single crystal were estimated in an aqueous solution using the classical homogeneous nucleation theory. The solubility, metastable zonewidth and induction period were determined experimentally by employing gravimetric, polythermal and isothermal method respectively. The interfacial energy was determined using the induction period values and the same was used for the further evaluation of the nucleation parameters. It was observed that the nucleation rate increases with an increase in supersaturation and hence nucleation is more probable at a higher value of supersaturation. Bulk size GPI single crystals were grown using the optimized nucleation parameters. The crystalline perfection and the defects of the as grown specimens were studied and the obtained results have been presented in this paper.
|
|
| 10. |
- Prashanth, K.G., et al.
(författare)
-
Microstructure and mechanical properties of Al-12Si produced by selective laser melting: Effect of heat treatment
- 2014
-
Ingår i: Materials Science & Engineering A: Structural Materials: Properties, Microstructure and Processing. - : Elsevier BV. - 0921-5093 .- 1873-4936. ; 590, s. 153-160
-
Tidskriftsartikel (refereegranskat)abstract
- Al-12Si specimens are produced by selective laser melting (SLM) from gas atomized powders. An extremely fine cellular structure is observed with residual free Si along the cellular boundaries. Room temperature tensile tests reveal a remarkable mechanical behavior: the samples show yield and tensile strengths of about 260. MPa and 380. MPa, respectively, along with fracture strain of ~3%. The effect of annealing on microstructure and related tensile properties is examined and the results demonstrate that the mechanical behavior of the Al-12Si SLM samples can be tuned within a wide range of strength and ductility through proper annealing treatment.
|
|
