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- Bois, G., et al.
(författare)
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Benchmark DEBORA: Assessment of MCFD compared to high-pressure boiling pipe flow measurements
- 2024
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Ingår i: International Journal of Multiphase Flow. - : Elsevier Ltd. - 0301-9322 .- 1879-3533. ; 179
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Tidskriftsartikel (refereegranskat)abstract
- A benchmark activity on two-fluid simulations of high-pressure boiling upward flows in a pipe is performed by 12 participants using different MCFD (Multiphase Computational Fluid Dynamics) codes and closure relationships. More than 30 conditions from DEBORA experiment conducted by CEA are considered. Each case is characterised by the flow rate, inlet temperature, wall heat flux and outlet pressure. High-pressure Freon (R12) at 14 bar and 26 bar is boiled in a 19.2mm pipe heated over 3.5m. Flow rates range from 2000 kg m−2 s−1 to 5000 kg m−2 s−1 and exit quality x ranges from single-phase conditions to x=0.1 which leads to a peak void fraction of α=70%. In these high pressure conditions, bubbles remain small and there is no departure from the bubbly flow regime (François et al., 2011; Hösler, 1968). However, different kind of bubbly flows are observed: wall-peak, intermediate peak or core-peak, depending on the case considered. Measurements along the pipe radius near the end of the heated section are compared to code predictions. They include void fraction, bubble mean diameter, vapour velocity and liquid temperature. The benchmark covered two phases. In the first phase of the benchmark activities, experimental data were given to the participants, allowing to compare the simulation results and to develop, to select or to adjust the models in the CMFD codes. The second phase included blind cases where the participants could not compare to the measurements. In between the two phases, possible additional model adjustments or calibrations were performed. Overall, the benchmark involved very different closures and a wide range of models’ complexity was covered. Yet, it is extremely difficult to have a robust closure for all conditions considered, even knowing experimental measurements. The wall-to-core peak transition is not captured consistently by the models. The degree of subcooling and the void fraction level are also difficult to assess. We were not capable of showing superiority of some physical closures, even for part of the model. The interaction between mechanisms and their hierarchy are extremely difficult to understand. Although departure from nucleate boiling (DNB) was not considered in this benchmarking exercise, it is expected that DNB predictions at high-pressure conditions depend strongly on the near-wall flow, temperature, and void fraction distributions. Therefore, the suitability of the closures also limits the accuracy of DNB predictions. The benchmark also demonstrated that in order to progress further in models development and validation, it is compulsory to have new measurements that include simultaneously as many variables as possible (including liquid temperature, velocity, cross-correlations and wall temperature); also, a better knowledge of the local bubble sizes distributions is the key to discriminate performances of interfacial area modelling (IATE, MUSIG or iMUSIG models, considering for instance the possibility of two classes of bubbles having totally different behaviour regarding the lift force). Following this benchmark impulse, we hope that future activities will be engaged on high-pressure boiling water experiments with a continuation of models’ comparisons and development.
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2. |
- Schoemaker, Minouk J., et al.
(författare)
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Adult weight change and premenopausal breast cancer risk : A prospective pooled analysis of data from 628,463 women
- 2020
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Ingår i: International Journal of Cancer. - : John Wiley & Sons. - 0020-7136 .- 1097-0215. ; 147:5, s. 1306-1314
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Tidskriftsartikel (refereegranskat)abstract
- Early-adulthood body size is strongly inversely associated with risk of premenopausal breast cancer. It is unclear whether subsequent changes in weight affect risk. We pooled individual-level data from 17 prospective studies to investigate the association of weight change with premenopausal breast cancer risk, considering strata of initial weight, timing of weight change, other breast cancer risk factors and breast cancer subtype. Hazard ratios (HR) and 95% confidence intervals (CI) were obtained using Cox regression. Among 628,463 women, 10,886 were diagnosed with breast cancer before menopause. Models adjusted for initial weight at ages 18-24 years and other breast cancer risk factors showed that weight gain from ages 18-24 to 35-44 or to 45-54 years was inversely associated with breast cancer overall (e.g., HR per 5 kg to ages 45-54: 0.96, 95% CI: 0.95-0.98) and with oestrogen-receptor(ER)-positive breast cancer (HR per 5 kg to ages 45-54: 0.96, 95% CI: 0.94-0.98). Weight gain from ages 25-34 was inversely associated with ER-positive breast cancer only and weight gain from ages 35-44 was not associated with risk. None of these weight gains were associated with ER-negative breast cancer. Weight loss was not consistently associated with overall or ER-specific risk after adjusting for initial weight. Weight increase from early-adulthood to ages 45-54 years is associated with a reduced premenopausal breast cancer risk independently of early-adulthood weight. Biological explanations are needed to account for these two separate factors.
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3. |
- Timmins, Iain R., et al.
(författare)
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International pooled analysis of leisure-time physical activity and premenopausal breast cancer in women from 19 cohorts
- 2024
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Ingår i: Journal of Clinical Oncology. - : American Society of Clinical Oncology. - 0732-183X .- 1527-7755. ; 42:8, s. 927-939
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: There is strong evidence that leisure-time physical activity is protective against postmenopausal breast cancer risk but the association with premenopausal breast cancer is less clear. The purpose of this study was to examine the association of physical activity with the risk of developing premenopausal breast cancer.METHODS: We pooled individual-level data on self-reported leisure-time physical activity across 19 cohort studies comprising 547,601 premenopausal women, with 10,231 incident cases of breast cancer. Multivariable Cox regression was used to estimate hazard ratios (HRs) and 95% CIs for associations of leisure-time physical activity with breast cancer incidence. HRs for high versus low levels of activity were based on a comparison of risk at the 90th versus 10th percentiles of activity. We assessed the linearity of the relationship and examined subtype-specific associations and effect modification across strata of breast cancer risk factors, including adiposity.RESULTS: Over a median 11.5 years of follow-up (IQR, 8.0-16.1 years), high versus low levels of leisure-time physical activity were associated with a 6% (HR, 0.94 [95% CI, 0.89 to 0.99]) and a 10% (HR, 0.90 [95% CI, 0.85 to 0.95]) reduction in breast cancer risk, before and after adjustment for BMI, respectively. Tests of nonlinearity suggested an approximately linear relationship (Pnonlinearity = .94). The inverse association was particularly strong for human epidermal growth factor receptor 2-enriched breast cancer (HR, 0.57 [95% CI, 0.39 to 0.84]; Phet = .07). Associations did not vary significantly across strata of breast cancer risk factors, including subgroups of adiposity.CONCLUSION: This large, pooled analysis of cohort studies adds to evidence that engagement in higher levels of leisure-time physical activity may lead to reduced premenopausal breast cancer risk.
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- Von Holle, Ann, et al.
(författare)
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BMI and breast cancer risk around age at menopause
- 2024
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Ingår i: Cancer Epidemiology. - : Elsevier. - 1877-7821 .- 1877-783X. ; 89
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Tidskriftsartikel (refereegranskat)abstract
- Background: A high body mass index (BMI, kg/m2) is associated with decreased risk of breast cancer before menopause, but increased risk after menopause. Exactly when this reversal occurs in relation to menopause is unclear. Locating that change point could provide insight into the role of adiposity in breast cancer etiology.Methods: We examined the association between BMI and breast cancer risk in the Premenopausal Breast Cancer Collaborative Group, from age 45 up to breast cancer diagnosis, loss to follow-up, death, or age 55, whichever came first. Analyses included 609,880 women in 16 prospective studies, including 9956 who developed breast cancer before age 55. We fitted three BMI hazard ratio (HR) models over age-time: constant, linear, or nonlinear (via splines), applying piecewise exponential additive mixed models, with age as the primary time scale. We divided person-time into four strata: premenopause; postmenopause due to natural menopause; postmenopause because of interventional loss of ovarian function (bilateral oophorectomy (BO) or chemotherapy); postmenopause due to hysterectomy without BO. Sensitivity analyses included stratifying by BMI in young adulthood, or excluding women using menopausal hormone therapy.Results: The constant BMI HR model provided the best fit for all four menopausal status groups. Under this model, the estimated association between a five-unit increment in BMI and breast cancer risk was HR=0.87 (95% CI: 0.85, 0.89) before menopause, HR=1.00 (95% CI: 0.96, 1.04) after natural menopause, HR=0.99 (95% CI: 0.93, 1.05) after interventional loss of ovarian function, and HR=0.88 (95% CI: 0.76, 1.02) after hysterectomy without BO.Conclusion: The BMI breast cancer HRs remained less than or near one during the 45–55 year age range indicating that the transition to a positive association between BMI and risk occurs after age 55.
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