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Daclatasvir combine...
Daclatasvir combined with sofosbuvir or simeprevir in liver transplant recipients with severe recurrent hepatitis C infection
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Fontana, Robert J. (författare)
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Brown, Robert S., Jr. (författare)
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Moreno-Zamora, Ana (författare)
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visa fler...
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Prieto, Martin (författare)
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Joshi, Shobha (författare)
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Londono, Maria-Carlota (författare)
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Herzer, Kerstin (författare)
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Chacko, Kristina R. (författare)
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Stauber, Rudolf E. (författare)
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Knop, Viola (författare)
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Jafri, Syed-Mohammed (författare)
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Castells, Lluis (författare)
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Ferenci, Peter (författare)
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Torti, Carlo (författare)
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Durand, Christine M. (författare)
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Loiacono, Laura (författare)
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Lionetti, Raffaella (författare)
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Bahirwani, Ranjeeta (författare)
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- Weiland, Ola (författare)
- Karolinska Institutet
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Mubarak, Abdullah (författare)
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ElSharkawy, Ahmed M. (författare)
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Stadler, Bernhard (författare)
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Montalbano, Marzia (författare)
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Berg, Christoph (författare)
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Pellicelli, Adriano M. (författare)
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- Stenmark, Stephan (författare)
- Umeå universitet,Infektionssjukdomar
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Vekeman, Francis (författare)
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Ionescu-Ittu, Raluca (författare)
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Emond, Bruno (författare)
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Reddy, K. Rajender (författare)
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(creator_code:org_t)
- 2016-03-28
- 2016
- Engelska.
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Ingår i: Liver transplantation. - : Ovid Technologies (Wolters Kluwer Health). - 1527-6465 .- 1527-6473. ; 22:4, s. 446-458
- Relaterad länk:
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https://aasldpubs.on...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Daclatasvir (DCV) is a potent, pangenotypic nonstructural protein 5A inhibitor with demonstrated antiviral efficacy when combined with sofosbuvir (SOF) or simeprevir (SMV) with or without ribavirin (RBV) in patients with chronic hepatitis C virus (HCV) infection. Herein, we report efficacy and safety data for DCV-based all-oral antiviral therapy in liver transplantation (LT) recipients with severe recurrent HCV. DCV at 60mg/day was administered for up to 24 weeks as part of a compassionate use protocol. The study included 97 LT recipients with a mean age of 59.3 +/- 8.2 years; 93% had genotype 1 HCV and 31% had biopsy-proven cirrhosis between the time of LT and the initiation of DCV. The mean Model for End-Stage Liver Disease (MELD) score was 13.0 +/- 6.0, and the proportion with Child-Turcotte-Pugh (CTP) A/B/C was 51%/31%/12%, respectively. Mean HCV RNA at DCV initiation was 14.3x6 log(10) IU/mL, and 37% had severe cholestatic HCV infection. Antiviral regimens were selected by the local investigator and included DCV+SOF (n=77), DCV+SMV (n=18), and DCV+SMV+SOF (n=2); 35% overall received RBV. At the end of treatment (EOT) and 12 weeks after EOT, 88 (91%) and 84 (87%) patients, respectively, were HCV RNA negative or had levels <43 IU/mL. CTP and MELD scores significantly improved between DCV-based treatment initiation and last contact. Three virological breakthroughs and 2 relapses occurred in patients treated with DCV+SMV with or without RBV. None of the 8 patient deaths (6 during and 2 after therapy) were attributed to therapy. In conclusion, DCV-based all-oral antiviral therapy was well tolerated and resulted in a high sustained virological response in LT recipients with severe recurrent HCV infection. Most treated patients experienced stabilization or improvement in their clinical status.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
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- Av författaren/redakt...
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Fontana, Robert ...
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Brown, Robert S. ...
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Moreno-Zamora, A ...
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Prieto, Martin
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Joshi, Shobha
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Londono, Maria-C ...
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visa fler...
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Herzer, Kerstin
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Chacko, Kristina ...
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Stauber, Rudolf ...
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Knop, Viola
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Jafri, Syed-Moha ...
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Castells, Lluis
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Ferenci, Peter
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Torti, Carlo
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Durand, Christin ...
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Loiacono, Laura
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Lionetti, Raffae ...
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Bahirwani, Ranje ...
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Weiland, Ola
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Mubarak, Abdulla ...
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ElSharkawy, Ahme ...
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Stadler, Bernhar ...
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Montalbano, Marz ...
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Berg, Christoph
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Pellicelli, Adri ...
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Stenmark, Stepha ...
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Vekeman, Francis
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Ionescu-Ittu, Ra ...
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Emond, Bruno
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Reddy, K. Rajend ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Infektionsmedici ...
- Artiklar i publikationen
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Liver transplant ...
- Av lärosätet
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Umeå universitet
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Karolinska Institutet