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Sökning: WFRF:(Bailey Vanessa) > (2007-2009)

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1.
  • Harrison, Stephan, et al. (författare)
  • Glaciar Leon, Chilean Patagonia: late-Holocene chronology and geomorphology
  • 2008
  • Ingår i: Holocene. - : SAGE Publications. - 0959-6836. ; 18:4, s. 643-652
  • Tidskriftsartikel (refereegranskat)abstract
    • Glaciar Leon is a temperate, grounded outlet of the eastern North Patagonian Icefield (NPI). It terminates at an active calving margin in Lago Leones, a 10 km long proglacial lake. We take a multidisciplinary approach to its description and use ASTER imagery and clast sedimentology to describe the geomorphology of the glacier and its associated moraines. We date periods of glacier retreat over the last 2500 years using a combination of lichenometric, dendrochronological, cosmogenic and optically stimulated luminescence techniques and show that the glacier receded from a large terminal moraine complex some 2500 years ago and underwent further significant recession from nineteenth-century moraine limits. The moraine dates indicate varying retreat rates, in conjunction with significant downwasting. The bathymetry of Lago Leones is characterized by distinct ridges interpreted as moraine ridges that dissect the lake into several basins, with water depths reaching 360 m. The fluctuations of Glaciar Leon appear to have been controlled by the interplay between climatic forcing and calving dynamics.
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2.
  • Szatmari, Peter, et al. (författare)
  • Mapping autism risk loci using genetic linkage and chromosomal rearrangements.
  • 2007
  • Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 39:3, s. 319-328
  • Tidskriftsartikel (refereegranskat)abstract
    • Autism spectrum disorders (ASDs) are common, heritable neurodevelopmental conditions. The genetic architecture of ASDs is complex, requiring large samples to overcome heterogeneity. Here we broaden coverage and sample size relative to other studies of ASDs by using Affymetrix 10K SNP arrays and 1,168 families with at least two affected individuals, performing the largest linkage scan to date while also analyzing copy number variation in these families. Linkage and copy number variation analyses implicate chromosome 11p12-p13 and neurexins, respectively, among other candidate loci. Neurexins team with previously implicated neuroligins for glutamatergic synaptogenesis, highlighting glutamate-related genes as promising candidates for contributing to ASDs.
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