| 1. |
- Stacchiotti, S., et al.
(författare)
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Epithelioid hemangioendothelioma, an ultra-rare cancer : a consensus paper from the community of experts
- 2021
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Ingår i: ESMO Open. - : Elsevier BV. - 2059-7029. ; 6:3
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Forskningsöversikt (refereegranskat)abstract
- Epithelioid hemangioendothelioma (EHE) is an ultra-rare, translocated, vascular sarcoma. EHE clinical behavior is variable, ranging from that of a low-grade malignancy to that of a high-grade sarcoma and it is marked by a high propensity for systemic involvement. No active systemic agents are currently approved specifically for EHE, which is typically refractory to the antitumor drugs used in sarcomas. The degree of uncertainty in selecting the most appropriate therapy for EHE patients and the lack of guidelines on the clinical management of the disease make the adoption of new treatments inconsistent across the world, resulting in suboptimal outcomes for many EHE patients. To address the shortcoming, a global consensus meeting was organized in December 2020 under the umbrella of the European Society for Medical Oncology (ESMO) involving >80 experts from several disciplines from Europe, North America and Asia, together with a patient representative from the EHE Group, a global, disease-specific patient advocacy group, and Sarcoma Patient EuroNet (SPAEN). The meeting was aimed at defining, by consensus, evidence-based best practices for the optimal approach to primary and metastatic EHE. The consensus achieved during that meeting is the subject of the present publication.
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| 2. |
- Lutu, A., et al.
(författare)
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Measuring Roaming in Europe : Infrastructure and Implications on Users QoE
- 2021
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Ingår i: IEEE Transactions on Mobile Computing. - : Institute of Electrical and Electronics Engineers (IEEE). - 1536-1233 .- 1558-0660. ; 21:10, s. 3687-3699
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Tidskriftsartikel (refereegranskat)abstract
- "Roam like Home" is the initiative of the European Commission to end the levy of extra charges when roaming within the European region. As a result, people can use data services more freely across Europe. However, the implications of roaming solutions on network performance have not been carefully examined yet. This paper provides an in-depth characterization of the implications of international data roaming within Europe. We build a unique roaming measurement platform using 16 different mobile networks deployed in 6 countries across Europe. Using this platform, we measure different aspects of international roaming in 4G networks in Europe, including mobile network configuration, performance characteristics, and quality of experience. We find that operators adopt a common approach to implement roaming called Home-routed roaming. This results in additional latency penalties of 60 ms or more, depending on geographical distance. This leads to worse browsing performance, with an increase in the metrics related to Quality of Experience (QoE) of users (Page Load time and Speed Index) in the order of 15-20%. We further analyze the impact of latency on QoE metrics in isolation and find that the penalty imposed by Home Routing leads to degradation on QoE metrics up to 150% in case of intercontinental roaming. We make our dataset public to allow reproducing the results.
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