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Adaptive mechanopro...
Adaptive mechanoproperties mediated by the formin FMN1 characterize glioblastoma fitness for invasion
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- Monzo, Pascale (författare)
- IFOM Firc Inst Mol Oncol, Via Adamello 16, I-20139 Milan, Italy.
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- Crestani, Michele (författare)
- IFOM Firc Inst Mol Oncol, Via Adamello 16, I-20139 Milan, Italy.
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- Chong, Yuk Kien (författare)
- Natl Neurosci Inst, Dept Res, Singapore, Singapore.
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- Ghisleni, Andrea (författare)
- IFOM Firc Inst Mol Oncol, Via Adamello 16, I-20139 Milan, Italy.
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- Hennig, Katharina (författare)
- Univ Grenoble Alpes, F-38042 Grenoble, France.;CNRS, UMR 5588 LIPhy, F-38041 Grenoble, France.
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- Li, Qingsen (författare)
- IFOM Firc Inst Mol Oncol, Via Adamello 16, I-20139 Milan, Italy.
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- Kakogiannos, Nikolaos (författare)
- IFOM Firc Inst Mol Oncol, Via Adamello 16, I-20139 Milan, Italy.
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- Giannotta, Monica (författare)
- IFOM Firc Inst Mol Oncol, Via Adamello 16, I-20139 Milan, Italy.
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- Richichi, Cristina (författare)
- European Inst Oncol IRCCS, Dept Expt Oncol, IEO, I-20139 Milan, Italy.
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- Dini, Tania (författare)
- IFOM Firc Inst Mol Oncol, Via Adamello 16, I-20139 Milan, Italy.
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- Dejana, Elisabetta (författare)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,IFOM Firc Inst Mol Oncol, Via Adamello 16, I-20139 Milan, Italy
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- Maiuri, Paolo (författare)
- IFOM Firc Inst Mol Oncol, Via Adamello 16, I-20139 Milan, Italy.
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- Balland, Martial (författare)
- Univ Grenoble Alpes, F-38042 Grenoble, France.;CNRS, UMR 5588 LIPhy, F-38041 Grenoble, France.
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- Sheetz, Michael P. (författare)
- Univ Texas Med Branch, Dept Biochem & Mol Biol, Galveston, TX USA.;Natl Univ Singapore, Mechanobiol Inst, Singapore 117411, Singapore.
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- Pelicci, Giuliana (författare)
- European Inst Oncol IRCCS, Dept Expt Oncol, IEO, I-20139 Milan, Italy.;Piemonte Orientale Univ Amedeo Avogadro, Dept Translat Med, I-28100 Novara, Italy.
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- Ang, Beng Ti (författare)
- Duke Natl Univ Singapore, Singapore, Singapore.;Natl Neurosci Inst, Dept Neurosurg, Singapore, Singapore.
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- Tang, Carol (författare)
- Natl Neurosci Inst, Dept Res, Singapore, Singapore.;Nanyang Technol Univ, Sch Biol Sci, Singapore, Singapore.;Duke Natl Univ Singapore, Canc & Stem Cell Biol, Singapore, Singapore.
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- Gauthier, Nils C. (författare)
- IFOM Firc Inst Mol Oncol, Via Adamello 16, I-20139 Milan, Italy.
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IFOM Firc Inst Mol Oncol, Via Adamello 16, I-20139 Milan, Italy Natl Neurosci Inst, Dept Res, Singapore, Singapore. (creator_code:org_t)
- Elsevier, 2021
- 2021
- Engelska.
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Ingår i: Developmental Cell. - : Elsevier. - 1534-5807 .- 1878-1551. ; 56:20, s. 2841-2855.e8
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Glioblastoma are heterogeneous tumors composed of highly invasive and highly proliferative clones, Heterogeneity in invasiveness could emerge from discrete biophysical properties linked to specific molecular expression. We identified clones of patient-derived glioma propagating cells that were either highly proliferative or highly invasive and compared their cellular architecture, migratory, and biophysical properties. We discovered that invasiveness was linked to cellular fitness. The most invasive cells were stiffer, developed higher mechanical forces on the substrate, and moved stochastically. The mechano-chemical-induced expression of the formin FMN1 conferred invasive strength that was confirmed in patient samples. Moreover, FMN1 expression was also linked to motility in other cancer and normal cell lines, and its ectopic expression increased fitness parameters. Mechanistically, FMN1 acts from the microtubule lattice and promotes a robust mechanical cohesion, leading to highly invasive motility.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Monzo, Pascale
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Crestani, Michel ...
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Chong, Yuk Kien
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Ghisleni, Andrea
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Hennig, Katharin ...
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Li, Qingsen
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Kakogiannos, Nik ...
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Giannotta, Monic ...
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Richichi, Cristi ...
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Dini, Tania
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Dejana, Elisabet ...
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Maiuri, Paolo
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Balland, Martial
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Sheetz, Michael ...
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Pelicci, Giulian ...
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Ang, Beng Ti
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Tang, Carol
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Gauthier, Nils C ...
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Developmental Ce ...
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Uppsala universitet