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- Bradley, Patrick, et al.
(författare)
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Taking stock: A multistakeholder perspective on improving the delivery of care and the development of treatments for Alzheimer's disease.
- 2015
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Ingår i: Alzheimer's & dementia : the journal of the Alzheimer's Association. - : Wiley. - 1552-5279. ; 11:4, s. 455-461
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Tidskriftsartikel (refereegranskat)abstract
- Health-care stakeholders increasingly recognize that the scientific and economic challenges associated with Alzheimer's disease (AD) are simply too great for individual stakeholder groups to address solely from within their own silos. In the necessary spirit of collaboration, we present in this perspective a set of multicountry multistakeholder recommendations to improve the organization of existing AD and dementia care and the development of new treatments. In brief, the five recommendations are (1) health-care systems must make choices regarding the patient populations to be diagnosed and treated, (2) health-care systems should use an evidence-based standard of care, (3) increased collaboration between public and private institutions is needed to enhance research, (4) reimbursement end points need to be agreed on and validated, and (5) innovative business models should be used to spur the introduction of new medicines.
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| 2. |
- Wesnes, Keith A., et al.
(författare)
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Memantine improves attention and episodic memory in Parkinson's disease dementia and dementia with Lewy bodies
- 2015
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Ingår i: International Journal of Geriatric Psychiatry. - : Wiley. - 1099-1166 .- 0885-6230. ; 30:1, s. 46-54
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Tidskriftsartikel (refereegranskat)abstract
- ObjectiveIn both dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD), attentional dysfunction is a core clinical feature together with disrupted episodic memory. This study evaluated the cognitive effects of memantine in DLB and PDD using automated tests of attention and episodic memory. MethodsA randomised double-blind, placebo-controlled, 24-week three centre trial of memantine (20mg/day) was conducted in which tests of attention (simple and choice reaction time) and word recognition (immediate and delayed) from the CDR System were administered prior to dosing and again at 12 and 24weeks. Although other results from this study have been published, the data from the CDR System tests were not included and are presented here for the first time. ResultsData were available for 51 patients (21 DLB and 30 PDD). In both populations, memantine produced statistically significant medium to large effect sized improvements to choice reaction time, immediate and delayed word recognition. ConclusionsThese are the first substantial improvements on cognitive tests of attention and episodic recognition memory identified with memantine in either DLB or PDD. Copyright (c) 2014 John Wiley & Sons, Ltd.
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