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Genome-wide associa...
Genome-wide association study identifies tumor anatomical site-specific risk variants for colorectal cancer survival
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- Labadie, Julia D. (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Epidemiology, University of Washington, WA, Seattle, United States
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- Savas, Sevtap (författare)
- Discipline of Genetics, Faculty of Medicine, Memorial University, NL, St. John’s, Canada; Discipline of Oncology, Faculty of Medicine, Memorial University, NL, St. John’s, Canada
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- Harrison, Tabitha A. (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- Banbury, Barb (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- Huang, Yuhan (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Epidemiology, University of Washington, WA, Seattle, United States
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- Buchanan, Daniel D. (författare)
- Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, VIC, Melbourne, Australia; Colorectal Oncogenomics Group, Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, VIC, Parkville, Australia; Genetic Medicine and Family Cancer Clinic, The Royal Melbourne Hospital, VIC, Parkville, Australia
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- Campbell, Peter T. (författare)
- Department of Population Science, American Cancer Society, GA, Atlanta, United States
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- Gallinger, Steven J. (författare)
- Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, ON, Toronto, Canada
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- Giles, Graham G. (författare)
- Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, VIC, Melbourne, Australia; Cancer Epidemiology Division, Cancer Council Victoria, VIC, Melbourne, Australia; Medicine, School of Clinical Sciences at Monash Health, Monash University, VIC, Australia
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- Gunter, Marc J. (författare)
- Nutrition and Metabolism Section, International Agency for Research On Cancer, World Health Organization, Lyon, France
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- Hoffmeister, Michael (författare)
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Hsu, Li (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- Jenkins, Mark A. (författare)
- Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, VIC, Melbourne, Australia
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- Lin, Yi (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- Ogino, Shuji (författare)
- Program in Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, MA, Boston, United States; Cancer Immunology Program, Dana-Farber Harvard Cancer Center, MA, Boston, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States; Broad Institute of MIT and Harvard, MA, Cambridge, United States
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- Phipps, Amanda I. (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Epidemiology, University of Washington, WA, Seattle, United States
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- Slattery, Martha L. (författare)
- Department of Internal Medicine, University of Utah, UT, Salt Lake City, United States
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- Steinfelder, Robert S. (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- Sun, Wei (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- van Guelpen, Bethany (författare)
- Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Onkologi
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- Hua, Xinwei (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Epidemiology, University of Washington, WA, Seattle, United States
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- Figuieredo, Jane C. (författare)
- Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, CA, Los Angeles, United States; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
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- Pai, Rish K. (författare)
- Department of Laboratory Medicine and Pathology, Mayo Clinic, MN, Rochester, United States
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- Nassir, Rami (författare)
- Department of Pathology, School of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia
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- Qi, Lihong (författare)
- Department of Public Health Sciences, University of California Davis, CA, Davis, United States
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- Chan, Andrew T. (författare)
- Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Channing Division of Network Medicine, Brigham and Women’s Hospital and Harvard Medical School, MA, Boston, United States; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Broad Institute of Harvard and MIT, MA, Cambridge, United States
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- Peters, Ulrike (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Epidemiology, University of Washington, WA, Seattle, United States
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- Newcomb, Polly A. (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Epidemiology, University of Washington, WA, Seattle, United States
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Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Epidemiology, University of Washington, WA, Seattle, United States Discipline of Genetics, Faculty of Medicine, Memorial University, NL, St John’s, Canada; Discipline of Oncology, Faculty of Medicine, Memorial University, NL, St. John’s, Canada (creator_code:org_t)
- 2022-01-07
- 2022
- Engelska.
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Ingår i: Scientific Reports. - : Nature Publishing Group. - 2045-2322. ; 12:1
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Identification of new genetic markers may improve the prediction of colorectal cancer prognosis. Our objective was to examine genome-wide associations of germline genetic variants with disease-specific survival in an analysis of 16,964 cases of colorectal cancer. We analyzed genotype and colorectal cancer-specific survival data from a consortium of 15 studies. Approximately 7.5 million SNPs were examined under the log-additive model using Cox proportional hazards models, adjusting for clinical factors and principal components. Additionally, we ran secondary analyses stratifying by tumor site and disease stage. We used a genome-wide p-value threshold of 5 × 10–8 to assess statistical significance. No variants were statistically significantly associated with disease-specific survival in the full case analysis or in the stage-stratified analyses. Three SNPs were statistically significantly associated with disease-specific survival for cases with tumors located in the distal colon (rs698022, HR = 1.48, CI 1.30–1.69, p = 8.47 × 10–9) and the proximal colon (rs189655236, HR = 2.14, 95% CI 1.65–2.77, p = 9.19 × 10–9 and rs144717887, HR = 2.01, 95% CI 1.57–2.58, p = 3.14 × 10–8), whereas no associations were detected for rectal tumors. Findings from this large genome-wide association study highlight the potential for anatomical-site-stratified genome-wide studies to identify germline genetic risk variants associated with colorectal cancer-specific survival. Larger sample sizes and further replication efforts are needed to more fully interpret these findings.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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- Av författaren/redakt...
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Labadie, Julia D ...
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Savas, Sevtap
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Harrison, Tabith ...
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Banbury, Barb
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Huang, Yuhan
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Buchanan, Daniel ...
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visa fler...
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Campbell, Peter ...
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Gallinger, Steve ...
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Giles, Graham G.
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Gunter, Marc J.
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Hoffmeister, Mic ...
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Hsu, Li
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Jenkins, Mark A.
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Lin, Yi
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Ogino, Shuji
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Phipps, Amanda I ...
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Slattery, Martha ...
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Steinfelder, Rob ...
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Sun, Wei
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van Guelpen, Bet ...
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Hua, Xinwei
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Figuieredo, Jane ...
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Pai, Rish K.
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Nassir, Rami
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Qi, Lihong
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Chan, Andrew T.
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Peters, Ulrike
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Newcomb, Polly A ...
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