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Träfflista för sökning "WFRF:(Baran E) srt2:(2005-2009)"

Sökning: WFRF:(Baran E) > (2005-2009)

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1.
  • Baran, M, et al. (författare)
  • SURVIVIN IS AN ESSENTIAL MEDIATOR OF ARTHRITIS INTERACTING WITH UROKINASE SIGNALLING.
  • 2009
  • Ingår i: Journal of cellular and molecular medicine. - : Wiley. - 1582-4934 .- 1582-1838. ; 13:9B, s. 3797-3808
  • Tidskriftsartikel (refereegranskat)abstract
    • ABSTRACT Proto-oncogene survivin has recently been identified as a prognostic marker distinguishing patients with destructive rheumatoid arthritis (RA). In the present material of 132 RA patients and 82 controls the levels of survivin correlated to urokinase (uPA) (r=0.46), a plasminogen activator over expressed in inflamed joints and known to exhibit potent arthritogenic properties. Here we evaluate the functional relationship between these proteins using primary synovial fibroblasts and leukocytes of RA patients, human monocytic (THP-1) and fibroblast (MRC-5) cell lines. Using inhibitors of intracellular signalling we show that uPA and survivin share common transduction pathways being in synovial fibroblasts dependent on the activity of tyrosine kinases, PI3-kinase and MEK. Moreover, uPA production is significantly reduced in fibroblasts if survivin synthesis has been silenced by siRNA. Importantly, silencing of survivin in fibroblasts prevented their invasive growth in knee joints of SCID mice. Interaction of uPA with receptor up regulates survivin expression in leukocytes. In turn, survivin is required for the upregulation of uPA receptor on cell surface. These findings indicate that survivin is an essential mediator of arthritogenic properties of uPA regulating its synthesis in synovial fibroblasts and uPAR expression in leukocytes. Close correlation between survivin and uPA levels in patients with RA supports the importance of this connection for the pathogenesis of arthritis.
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2.
  • Larsson, Andreas, et al. (författare)
  • Modelling of Carbon Nanotube Catalytic Growth
  • 2008
  • Konferensbidrag (refereegranskat)abstract
    • Carbon nanotubes (CNTs) have; due to their remarkable mechanical; electronic and thermal properties; many suggested uses; and have even been demonstrated as interconnects and nano-transistors in laboratory built devices [1-4]. The reason CNTs are not yet incorporated into electronics is due to growth control and placement issues. With present day state-of-the-art techniques it is not possible to grow CNTs with only one property (i.e. either all metallic or all semiconducting); which presents the first and principal hurdle for the utilisation of CNTs in semiconductor industry. It is; however; possible to grow CNTs of a certain type (multi-walled; double-walled; or single walled); within a rather narrow diameter distribution. It is also well understood how the orientation of the honey-comb structure relative to the CNT axis determines the property of the CNT itself. The problem lies in realizing growth of CNTs with control over this internal graphene structuring. We have performed first-principles calculations of how single-walled carbon nanotubes (SWNTs) bond with different metal nanoparticles explaining why the traditional catalysts (Fe; Co; Ni) are more successful than other metals (Cu; Pd; Au) [5]; and how this realization relates to new nanocomposite catalyst particles (Cu/Mo) [6]. We will present our contribution to understanding the mechanism of catalytic CNT growth; since it is only through better knowledge that property-controlled growth of CNTs can be achieved
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