1. |
|
|
2. |
- Barbosa, Edna J L, 1961, et al.
(författare)
-
Influence of the Exon 3-deleted/full-length Growth Hormone Receptor Polymorphism on the Response to Growth Hormone Replacement Therapy in Adults with Severe Growth Hormone Deficiency. : d3-GHR isoform in GHD adults
- 2009
-
Ingår i: The Journal of clinical endocrinology and metabolism. - : The Endocrine Society. - 0021-972X .- 1945-7197. ; 94:2, s. 639-644
-
Tidskriftsartikel (refereegranskat)abstract
- Context: There is considerable individual variation in the clinical response to growth hormone (GH) replacement therapy in GH deficient (GHD) adults. Useful predictors of treatment response are lacking. Objective: To assess the influence of the exon 3-deleted (d3-GHR) and full-length (fl-GHR) GH receptor isoforms on the response to GH replacement therapy in adults with severe GHD. Design, Patients: 124 adult GHD patients (79 men, median age 50 years) were studied before and after 12 months of GH therapy. GHD patients were divided into those bearing fl/fl alleles (Group 1) and those bearing at least one d3-GHR allele (Group 2), and the genotype was related to the effects of GH therapy on IGF-I levels and total body fat (BF). Intervention: GH dose was individually titrated to obtain normal serum IGF-I levels. Main Outcome Measures: GHR genotype was determined by PCR amplification, IGF-I levels by immunoassay, and BF by a four-compartment model. Results: Seventy-two (58%) patients had fl/fl genotype and were classified as Group 1, while 52 (42%) had at least one d3-GHR allele and were classified as Group 2 (40 were heterozygous and 12 were homozygous). At baseline, there were no significant differences in the study groups. Changes in IGF-I and BF after 12 months of GH treatment did not differ significantly between the two genotype groups. Conclusion: The presence of d3-GHR allele did not influence the response to GH replacement therapy in our cohort of adults with severe GHD.
|
|
3. |
- Nunes, S. C., et al.
(författare)
-
Cationic and anionic environments in LiTFSI-doped di-ureasils with application in solid-state electrochromic devices
- 2008
-
Ingår i: Chemical Physics. - : Elsevier BV. - 0301-0104. ; 345:1, s. 32-40
-
Tidskriftsartikel (refereegranskat)abstract
- Fourier Transform mid-infrared and Raman spectroscopies were used to investigate the cation/polymer, cation/urea bridge, cation/anion and hydrogen bonding interactions in poly(oxyethylene) (POE)/siloxane di-ureasil networks prepared by the sol-gel route and doped with lithium bis(trifluoromethanesulfonyl)imide (LiTFSI). Materials with compositions 200 >= n >= 5 (where n expresses the molar ratio OCH2CH2/Li+) were studied. The Li+ ions coordinate to the urea carbonyl oxygen atoms over the whole range of salt concentration considered. Bonding to the ether oxygen atoms of the POE chains occurs at n
|
|
4. |
- Nunes, S. C., et al.
(författare)
-
Spectroscopic and structural studies of di-ureasils doped with lithium perchlorate
- 2007
-
Ingår i: Electrochimica Acta. - : Elsevier BV. - 0013-4686. ; 53:4, s. 1466-1475
-
Tidskriftsartikel (refereegranskat)abstract
- Di-urea cross-linked POE/siloxane hybrid ormolytes (di-ureasils) doped with a wide concentration range of lithium perchlorate trihydrate (LiClO4 center dot 3H(2)O) (200 >= n >= 0.5, where n expresses the salt content in terms of the number of ether oxygen atoms per Li+ ion) have been analysed by Fourier transform infrared and Raman (FT-IR and FT-Raman, respectively) spectroscopies and X-ray diffraction (XRD). The results obtained lead us to conclude that the xerogels with n >= 5 are totally amorphous. At n
|
|
5. |
- Silva, M. M., et al.
(författare)
-
Sol-gel preparation of a di-ureasil electrolyte doped with lithium perchlorate
- 2006
-
Ingår i: Electrochimica Acta. - : Elsevier BV. - 0013-4686. ; 52:4, s. 1542-1548
-
Tidskriftsartikel (refereegranskat)abstract
- Solid polymer electrolytes (SPEs) synthesized by the sol-gel process and designated as di-ureasils have been prepared through the incorporation of lithium perchlorate, LiClO4, into the d-U(2000) organic-inorganic hybrid network. Electrolytes with lithium salt compositions of n (where n indicates the number of oxyethylene units per Li+ ion) between ∞ and 0.5 were characterized by conductivity measurements, cyclic voltammetry at a gold microelectrode, thermal analysis and Fourier transform Raman (FT-Raman) spectroscopy. The conductivity results obtained suggest that this system offers a quite significant improvement over previously characterized analogues doped with lithium triflate [S.C. Nunes, V. de Zea Bermudez, D. Ostrovskii, M.M. Silva, S. Barros, M.J. Smith, R.A. Sá Ferreira, L.D. Carlos, J. Rocha, E. Morales, J. Electrochem. Soc. 152 (2) (2005), A429]. "Free" perchlorate ions, detected in all the samples examined, are identified as the main charge carriers in the sample that yields the highest room temperature conductivity (n = 20). In the di-ureasils with n ≤ 10 ionic association is favoured and the ionic conductivity drops.
|
|