SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Barker Gillian) srt2:(2010-2014)"

Sökning: WFRF:(Barker Gillian) > (2010-2014)

  • Resultat 1-2 av 2
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Lindell, Fredrik, et al. (författare)
  • Vanligt med antibiotikaresistens hos barn med urinvägsavledning
  • 2011
  • Ingår i: Läkartidningen. - 0023-7205 .- 1652-7518. ; 108:46, s. 2376-2379
  • Tidskriftsartikel (refereegranskat)abstract
    • The use of prophylactic antibiotics during urinary stenting or catheterisation in paediatric urology is controversial. The aim of this retrospective study was to determine the prevalence of bacterial antibiotic resistance found in urine cultures during antibiotic prophylaxis. The results of urine culture during the years 2006-2007 were used in the study. The children who were not receiving antibiotic prophylaxis had a higher proportion of E coli compared to those with prophylaxis. Gram-positive bacteria (i.e. coagulase negative staphylococci and enterococci) and E cloacae had a marked dominance in children who received low dose antibiotic prophylaxis. In patients with a stent or catheter and prophylaxis, the bacteria were resistant in 79.3% (23/29) compared to only 28.6% (10/35) in those who received no prophylaxis (p=0.0175). Low dose of antibiotic prophylaxis is associated with development of antibiotic resistant bacteria in children with urinary stents or catheters.
  •  
2.
  • Reutter, Heiko, et al. (författare)
  • Genome-wide association study and mouse expression data identify a highly conserved 32kb intergenic region between WNT3 and WNT9b as possible susceptibility locus for isolated classic exstrophy of the bladder.
  • 2014
  • Ingår i: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 23:20, s. 5536-5544
  • Tidskriftsartikel (refereegranskat)abstract
    • Bladder Exstrophy-Epispadias Complex (BEEC), the severe end of the uro-rectal malformation spectrum, has a profound impact on continence as well as sexual and renal functions. It is widely accepted that for the majority of cases the genetic basis appears to be multifactorial. Here, we report the first study which utilizes genome-wide association methods to analyze a cohort comprising patients presenting the most common BEEC form, classic bladder exstrophy (CBE), to identify common variation associated with risk for isolated CBE. We employed discovery and follow-up samples comprising 218/865 cases/controls and 78 trios in total, all of European descent. Our discovery sample identified a marker near SALL1, showing genome-wide significant association with CBE. However, analyses performed on follow-up samples did not add further support to these findings. We were also able to identify an association with CBE across our study samples (discovery: P=8.88 x 10(-5); follow-up: P=0.0025; combined: 1.09 x 10(-6)) in a highly conserved 32kb intergenic region containing regulatory elements between WNT3 and WNT9B. Subsequent analyses in mice revealed expression for both genes in the genital region during stages relevant to the development of CBE in humans. Unfortunately, we were not able to replicate the suggestive signal for WNT3 and WNT9B in a sample that was enriched for non-CBE BEEC cases (P=0.51). Our suggestive findings support the hypothesis that larger samples are warranted to identify association of common variation with CBE.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-2 av 2

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy