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- Aad, G., et al.
(författare)
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- 2012
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swepub:Mat__t (refereegranskat)
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| 2. |
- Adamo, Angela, et al.
(författare)
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Legacy ExtraGalactic UV Survey with The Hubble Space Telescope : Stellar Cluster Catalogs and First Insights Into Cluster Formation and Evolution in NGC 628
- 2017
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Ingår i: Astrophysical Journal. - : IOP PUBLISHING LTD. - 0004-637X .- 1538-4357. ; 841:2
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Tidskriftsartikel (refereegranskat)abstract
- We report the large effort that is producing comprehensive high-level young star cluster (YSC) catalogs for a significant fraction of galaxies observed with the Legacy ExtraGalactic UV Survey (LEGUS) Hubble treasury program. We present the methodology developed to extract cluster positions, verify their genuine nature, produce multiband photometry (from NUV to NIR), and derive their physical properties via spectral energy distribution fitting analyses. We use the nearby spiral galaxy NGC 628 as a test case for demonstrating the impact that LEGUS will have on our understanding of the formation and evolution of YSCs and compact stellar associations within their host galaxy. Our analysis of the cluster luminosity function from the UV to the NIR finds a steepening at the bright end and at all wavelengths suggesting a dearth of luminous clusters. The cluster mass function of NGC 628 is consistent with a power-law distribution of slopes similar to-2 and a truncation of a few times 10(5) M-circle dot. After their formation, YSCs and compact associations follow different evolutionary paths. YSCs survive for a longer time frame, confirming their being potentially bound systems. Associations disappear on timescales comparable to hierarchically organized star-forming regions, suggesting that they are expanding systems. We find massindependent cluster disruption in the inner region of NGC 628, while in the outer part of the galaxy there is little or no disruption. We observe faster disruption rates for low mass (<= 10(4) M-circle dot) clusters, suggesting that a massdependent component is necessary to fully describe the YSC disruption process in NGC 628.
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| 4. |
- Barlind, Jonas G, et al.
(författare)
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Design and optimization of pyrazinecarboxamide-based inhibitors of diacylglycerol acyltransferase 1 (DGAT1) leading to a clinical candidate dimethylpyrazinecarboxamide phenylcyclohexylacetic acid (AZD7687)
- 2012
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Ingår i: Journal of Medicinal Chemistry. - : American Chemical Society (ACS). - 0022-2623 .- 1520-4804. ; 55:23, s. 10610-10629
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Tidskriftsartikel (refereegranskat)abstract
- A new series of pyrazinecarboxamide DGAT1 inhibitors was designed to address the need for a candidate drug with good potency, selectivity, and physical and DMPK properties combined with a low predicted dose in man. Rational design and optimization of this series led to the discovery of compound 30 (AZD7687), which met the project objectives for potency, selectivity, in particular over ACAT1, solubility, and preclinical PK profiles. This compound showed the anticipated excellent pharmacokinetic properties in human volunteers.
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| 9. |
- Scaramuzzino, Gabriella, 1979-
(författare)
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Sexsäljares och sexköpares kollektiva handlande på internet : En svensk "fuckförening"?
- 2014
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis aims to understand and explain the importance that prostitution forums have for the exercise of power and influence in the area of prostitution. It also seeks to clarify how these forums developed and were able to occur within a Swedish context. Sweden was the first country to legislate to criminalise only the buying, but not the sale, of sexual services. Social work provisions aims to get people out of prostitution. The thesis is based on an ethnographic study of the three largest Swedish prostitution forums during a two-year period. The empirical material consists of both quantitative participant and content analysis and field notes from observation of the interactions on the forums. The theoretical framework is based mainly on A Theory of Fields by Neil Fligstein and Doug McAdam. It focuses on the collective action on - and between - fields and how institutions are reproduced and changed. The results show that most of the content was published by a smaller group of actors. The interaction can be divided into the following subjects: social shims; information; negotiations and rules; advice and support; viewpoints on the forum as well as discussion on prostitution and its regulation. Moreover, the study shows that the forums enabled both sex service providers and sex clients to meet collectively, pursue common interests and discuss which rules should prevail in the prostitution market. Providers also pursued self-organised harm reduction social measures. This form of self-help was also sanctioned by a municipal prostitution unit, which can be interpreted as if it acted in a contrary direction to the government’s prostitution policy. The actors in the forums perceived themselves to be stigmatised by society, where sex service providers to a greater extent than sex clients, described a form of stigma. In the forums they could, however, feel a sense of belonging. The actors perceived themselves to be monitored by the Swedish state and they collectively self-regulated the interaction. Sex service providers and sex clients also co-operated, on occasions, with the Swedish state in order to jointly combat child prostitution, human trafficking and organised crime.
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| 10. |
- Özkahraman, Özer, 1992-
(författare)
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Multi-Agent Mission Planning and Execution for Small Autonomous Underwater Vehicles
- 2023
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Our planet is mostly covered in water, most of it still unexplored.In order to understand our environment better, oceanographers have been mapping and monitoring these waters using ship-mounted sensors and wired vehicles with limited range compared to the vastness of the oceans.The limited range and dependence on manned support vehicles has kept missions expensive and infrequent.To solve this problem, the sensors need to become independent of support vehicles, they need to venture into completely unexplored, unmapped regions of the seas by themselves and safely return with the data.This is where autonomous underwater vehicles (AUVs) have started to make a difference.In this thesis we investigate how multiple small AUVs can be utilized to efficiently and accurately sense very large volumes of water.Water absorbs electromagnetic radiation, meaning satellite-based global positioning systems (we will use GPS to refer to any such system), wide-angle cameras and radio communications are infeasible.These constraints ultimately result in uncertain localization of the vehicles.Furthermore, the vehicles are under constant disturbances from the water currents, fish and bio-fouling, which result in the dynamics of the vehicles being uncertain or even changing during the mission.In the first part of this thesis, we focus on the large-scale sensing problem under localization uncertainties by examining the caging and coverage problems.In the coverage problem, each AUV is uncertain about its exact position while tasked with sensing a stationary area.We show that we can still guarantee complete coverage and formulate the efficiency characteristics of different approaches.Furthermore, we show that when the vehicles are equipped with sensors and low-bandwidth communication methods, we can increase the effective range of a team of AUVs considerably by utilizing loop-closures over shared pose-graphs. In the caging problem, the localization uncertainty is focused on the entity that is being caged, its location is unknown but bounded.We show that through a combination of algorithms, the caging problem can be solved and a solution can be guaranteed, while simultaneously producing a list of specifications for the mission.In the second part, we focus on the individuals of the team and what they need to do in order for the team of AUVs to succeed.First, we identify that when there is a team of cooperative vehicles working together, conflicting goals rise.Each vehicle needs to pick between satisfying its own constraints and the constraints that come from being in a team. We propose a solution to this problem through a combination of Control Barrier Function (CBF) and Behavior Trees (BT).Secondly, we examine the possibility that a vehicle might undergo physical changes, like a broken thruster, that result in the vehicle being unable to complete the entire mission.Even in such a scenario, if the broken vehicle can still move to contact a normal one, the rest of the team can compensate through re-planning and the overall mission can still be completed.To do so, the broken vehicle must compensate for the change until a rendezvous.We propose a data-driven pipeline that can detect and plan around such a physical change within some bounds.
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