| 1. |
- Shulevski, A., et al.
(författare)
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The peculiar radio galaxy 4C 35.06 : a case for recurrent AGN activity?
- 2015
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 579, s. 1-10
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Tidskriftsartikel (refereegranskat)abstract
- Using observations obtained with the LOw Fequency ARray (LOFAR), the Westerbork Synthesis Radio Telescope (WSRT) and archival Very Large Array (VLA) data, we have traced the radio emission to large scales in the complex source 4C 35.06 located in the core of the galaxy cluster Abell 407. At higher spatial resolution (~ 4″), the source was known to have two inner radio lobes spanning 31 kpc and a diffuse, low-brightness extension running parallel to them, offset by about 11 kpc (in projection). At 62 MHz, we detect the radio emission of this structure extending out to 210 kpc. At 1.4 GHz and intermediate spatial resolution (~ 30″), the structure appears to have a helical morphology. We have derived the characteristics of the radio spectral index across the source. We show that the source morphology is most likely the result of at least two episodes of AGN activity separated by a dormant period of around 35 Myr. The outermost regions of radio emission have a steep spectral index (α< − 1), indicative of old plasma. We connect the spectral index properties of the resolved source structure with the integrated fluxdensity spectral index of 4C 35.06 and suggest an explanation for its unusual integrated flux density spectral shape (a moderately steep power law with no discernible spectral break), possibly providing a proxy for future studies of more distant radio sources through inferring their detailed spectral index properties and activity history from their integrated spectral indices. The AGN is hosted by one of the galaxies located in the cluster core of Abell 407. We propose that it is intermittently active as it moves in the dense environment in the cluster core. In this scenario, the AGN turned on sometime in the past, and has produced the helical pattern of emission, possibly a sign of jet precession/merger during that episode of activity. Using LOFAR, we can trace the relic plasma from that episode of activity out to greater distances from the core than ever before. Using the the WSRT, we detect H I in absorption against the center of the radio source. The absorption profile is relatively broad (FWHM of 288 kms-1), similar to what is found in other clusters. The derived column density is NHI ~ 4 × 1020 cm-2 for a Tspin = 100 K. This detection supports the connection – already suggested for other restarted radio sources – between the presence of cold gas and restarting activity. The cold gas appears to be dominated by a blue-shifted component although the broad H I profile could also include gas with different kinematics. Understanding the duty cycle of the radio emission as well as the triggering mechanism for starting (or restarting) the radio-loud activity can provide important constraints to quantify the impact of AGN feedback on galaxy evolution. The study of these mechanisms at low frequencies using morphological and spectral information promises to bring new important insights in this field.
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| 2. |
- Jansen, Willemijn J, et al.
(författare)
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Association of Cerebral Amyloid-β Aggregation With Cognitive Functioning in Persons Without Dementia.
- 2018
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Ingår i: JAMA psychiatry. - : American Medical Association (AMA). - 2168-6238 .- 2168-622X. ; 75:1, s. 84-95
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Tidskriftsartikel (refereegranskat)abstract
- Cerebral amyloid-β aggregation is an early event in Alzheimer disease (AD). Understanding the association between amyloid aggregation and cognitive manifestation in persons without dementia is important for a better understanding of the course of AD and for the design of prevention trials.To investigate whether amyloid-β aggregation is associated with cognitive functioning in persons without dementia.This cross-sectional study included 2908 participants with normal cognition and 4133 with mild cognitive impairment (MCI) from 53 studies in the multicenter Amyloid Biomarker Study. Normal cognition was defined as having no cognitive concerns for which medical help was sought and scores within the normal range on cognitive tests. Mild cognitive impairment was diagnosed according to published criteria. Study inclusion began in 2013 and is ongoing. Data analysis was performed in January 2017.Global cognitive performance as assessed by the Mini-Mental State Examination (MMSE) and episodic memory performance as assessed by a verbal word learning test. Amyloid aggregation was measured with positron emission tomography or cerebrospinal fluid biomarkers and dichotomized as negative (normal) or positive (abnormal) according to study-specific cutoffs. Generalized estimating equations were used to examine the association between amyloid aggregation and low cognitive scores (MMSE score ≤27 or memory z score≤-1.28) and to assess whether this association was moderated by age, sex, educational level, or apolipoprotein E genotype.Among 2908 persons with normal cognition (mean [SD] age, 67.4 [12.8] years), amyloid positivity was associated with low memory scores after age 70 years (mean difference in amyloid positive vs negative, 4% [95% CI, 0%-7%] at 72 years and 21% [95% CI, 10%-33%] at 90 years) but was not associated with low MMSE scores (mean difference, 3% [95% CI, -1% to 6%], P=.16). Among 4133 patients with MCI (mean [SD] age, 70.2 [8.5] years), amyloid positivity was associated with low memory (mean difference, 16% [95% CI, 12%-20%], P<.001) and low MMSE (mean difference, 14% [95% CI, 12%-17%], P<.001) scores, and this association decreased with age. Low cognitive scores had limited utility for screening of amyloid positivity in persons with normal cognition and those with MCI. In persons with normal cognition, the age-related increase in low memory score paralleled the age-related increase in amyloid positivity with an intervening period of 10 to 15 years.Although low memory scores are an early marker of amyloid positivity, their value as a screening measure for early AD among persons without dementia is limited.
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| 3. |
- Jansen, Willemijn J, et al.
(författare)
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Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis.
- 2015
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Ingår i: JAMA. - : American Medical Association (AMA). - 1538-3598 .- 0098-7484. ; 313:19, s. 1924-38
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Tidskriftsartikel (refereegranskat)abstract
- Cerebral amyloid-β aggregation is an early pathological event in Alzheimer disease (AD), starting decades before dementia onset. Estimates of the prevalence of amyloid pathology in persons without dementia are needed to understand the development of AD and to design prevention studies.
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| 4. |
- Bailey, D. L., et al.
(författare)
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Combined PET/MRI : from Status Quo to Status Go. Summary Report of the Fifth International Workshop on PET/MR Imaging; February 15-19, 2016; Tubingen, Germany
- 2016
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Ingår i: Molecular Imaging and Biology. - : Springer Science and Business Media LLC. - 1536-1632 .- 1860-2002. ; 18:5, s. 637-650
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Tidskriftsartikel (refereegranskat)abstract
- This article provides a collaborative perspective of the discussions and conclusions from the fifth international workshop of combined positron emission tomorgraphy (PET)/magnetic resonance imaging (MRI) that was held in Tubingen, Germany, from February 15 to 19, 2016. Specifically, we summarise the second part of the workshop made up of invited presentations from active researchers in the field of PET/MRI and associated fields augmented by round table discussions and dialogue boards with specific topics. This year, this included practical advice as to possible approaches to moving PET/MRI into clinical routine, the use of PET/MRI in brain receptor imaging, in assessing cardiovascular diseases, cancer, infection, and inflammatory diseases. To address perceived challenges still remaining to innovatively integrate PET and MRI system technologies, a dedicated round table session brought together key representatives from industry and academia who were engaged with either the conceptualisation or early adoption of hybrid PET/MRI systems. Discussions during the workshop highlighted that emerging unique applications of PET/MRI such as the ability to provide multi-parametric quantitative and visual information which will enable not only overall disease detection but also disease characterisation would eventually be regarded as compelling arguments for the adoption of PET/MR. However, as indicated by previous workshops, evidence in favour of this observation is only growing slowly, mainly due to the ongoing inability to pool data cohorts from independent trials as well as different systems and sites. The participants emphasised that moving from status quo to status go entails the need to adopt standardised imaging procedures and the readiness to act together prospectively across multiple PET/MRI sites and vendors.
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| 5. |
- Barthel, J., et al.
(författare)
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Understanding electron magnetic circular dichroism in a transition potential approach
- 2018
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Ingår i: Physical Review B. - 2469-9950 .- 2469-9969. ; 97:14
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Tidskriftsartikel (refereegranskat)abstract
- This paper introduces an approach based on transition potentials for inelastic scattering to understand the underlying physics of electron magnetic circular dichroism (EMCD). The transition potentials are sufficiently localized to permit atomic-scale EMCD. Two-beam and three-beam systematic row cases are discussed in detail in terms of transition potentials for conventional transmission electron microscopy, and the basic symmetries which arise in the three-beam case are confirmed experimentally. Atomic-scale EMCD in scanning transmission electron microscopy (STEM), using both a standard STEM probe and vortex beams, is discussed.
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| 6. |
- Emonts, B., et al.
(författare)
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The Dragonfly Galaxy: II. ALMA unveils a triple merger and gas exchange in a hyper-luminous radio galaxy at z = 2
- 2015
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 584
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Tidskriftsartikel (refereegranskat)abstract
- The Dragonfly Galaxy (MRC 0152-209), at redshift z similar to 2, is one of the most vigorously star-forming radio galaxies in the Universe. What triggered its activity? We present ALMA Cycle 2 observations of cold molecular CO(6 5) gas and dust, which reveal that this is likely a gas-rich triple merger. It consists of a close double nucleus (separation similar to 4 kpc) and a weak CO-emitter at similar to 10 kpc distance, all of which have counterparts in HST/NICMOS imagery. The hyper-luminous starburst and powerful radio-AGN were triggered at this precoalescent stage of the merger. The CO(6-5) traces dense molecular gas in the central region, and complements existing CO(1-0) data, which reveal more widespread tidal debris of cold gas. We also find similar to 10(10) M-circle dot of molecular gas with enhanced excitation at the highest velocities. At least 20-50% of this high-excitation, high-velocity gas shows kinematics that suggests it is being displaced and redistributed within the merger, although with line-of-sight velocities of vertical bar v vertical bar < 500 km s(-1), this gas will probably not escape the system. The processes that drive the redistribution of cold gas are likely related to either the gravitational interaction between two kpc-scale discs, or starburst/AGN-driven outflows. We estimate that the rate at which the molecular gas is redistributed is at least. M similar to 1200 +/- 500 M-circle dot yr(-1), and could perhaps even approach the star formation rate of similar to 3000 +/- 800 M-circle dot yr(-1). The fact that the gas depletion and gas redistribution timescales are similar implies that dynamical processes can be important in the evolution of massive high-z galaxies.
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| 7. |
- Shulevski, A., et al.
(författare)
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AGN duty cycle estimates for the ultra-steep spectrum radio relic VLSS J1431.8+1331
- 2015
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 583, s. A89-
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Tidskriftsartikel (refereegranskat)abstract
- Context. Steep spectrum radio sources associated with active galactic nuclei (AGN) may contain remnants of past AGN activity episodes. Studying these sources gives us insight into the AGN activity history. Novel instruments like the LOw Frequency ARray (LOFAR) are enabling studies of these fascinating structures to be made at tens to hundreds of MHz with sufficient resolution to analyse their complex morphology. Aims. Our goal is to characterize the integrated and resolved spectral properties of VESS J1431+1331 and estimate source ages based on synchrotron radio emission models, thus putting constraints on the AGN duty cycle. Methods. Using a broad spectral coverage, we have derived spectral and curvature maps, and used synchrotron ageing models to determine the time elapsed from the last time the source plasma was energized. We used LOFAR, Giant Metrewave Radio Telescope (GMRT) and Jansky Very Large Array (VLA) data. Results. We confirm the morphology and the spectral index values found in previous studies of this object. Based on our ageing analysis, we infer that the AGN that created this source currently has very low levels of activity or that it is switched off. The derived ages for the larger source component range from around 60 to 130 Myr, hinting that the AGN activity decreased or stopped around 60 Myr ago. We observe that the area around the faint radio core located in the larger source component is the youngest, while the overall age of the smaller source component shows it to be the oldest part of the source. Conclusions. Our analysis suggests that VLSS J1431.8+1331 is an intriguing, two-component source. The larger component seems to host a faint radio core, suggesting that the source may be an AGN radio relic. The spectral index we observe from the smaller component is distinctly flatter at lower frequencies than the spectral index of the larger component, suggesting the possibility that the smaller component may be a shocked plasma bubble. From. the integrated source spectrum, we deduce that its shape and slope can be used as tracers of the activity history of this type of steep spectrum radio source. We discuss the implications this conclusion has for future studies of radio sources having similar characteristics.
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