Effect of two kinds of pectin and guar gum on 1,2-dimethylhydrazine initiation of colon tumors and on fecal beta-glucuronidase activity in the rat

• The effect of 5% low-methoxylated pectin, high-methoxylated pectin, and guar gum on 1,2-dimethylhydrazine initiation of colon cancer was investigated using groups of 30 rats. The growth of the rats in the different groups was very similar to that of control group fed a fiber-free diet. Both kinds of pectin increased the multiplicity of color tumors, whereas guar gum did not significantly influence carcinogenesis. Bacterial beta-glucuronidase activity in feces and colonic content was the same in pectin-fed rats and controls but significantly lower in the guar gum group. Thus, it was not related to the number of tumors in each group.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Näringslära (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Nutrition and Dietetics (hsv//eng)

Nyckelord

Adenocarcinoma/chemically induced

Animals

Bacteria/enzymology

Body Weight

Cellulose/pharmacology

Colonic Neoplasms/chemically induced

Dietary Fiber/pharmacology

Dimethylhydrazines/toxicity

Feces/analysis

Glucuronidase/metabolism

Male

Methylhydrazines/toxicity

Pectins/pharmacology

Rats

Publikations- och innehållstyp

art (ämneskategori)

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