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- Fagher, K., et al.
(författare)
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Preparing for snow-sport events at the Paralympic Games in Beijing in 2022 : recommendations and remaining questions
- 2022
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Ingår i: BMJ Open Sport & Exercise Medicine. - : BMJ. - 2055-7647. ; 8:1
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Forskningsöversikt (refereegranskat)abstract
- During the 2022 Winter Paralympic Games in Beijing, the Para snow-sport events will be held at high altitudes and in possibly cold conditions while also requiring adjustment to several time zones. Furthermore, the ongoing COVID-19 pandemic may lead to suboptimal preparations. Another concern is the high rate of injuries that have been reported in the Para alpine and snowboard events. In addition to these challenges, Para athletes various impairments may affect both sports-specific demands and athlete health. However, the group of Para snow-sport athletes is an understudied population. Accordingly, this perspective paper summarises current knowledge to consider when preparing for the Paralympic Games in Beijing and point out important unanswered questions. We here focus specifically on how sport-specific demands and impairment-related considerations are influenced by altitude acclimatisation, cold conditions, travel fatigue and jetlag, complications due to the COVID-19 pandemic, and injury prevention and sports safety considerations. As Para athletes with spinal cord injury, limb deficiency, cerebral palsy and visual impairment account for the majority of the Para snow-sport athletes, the focus is mainly on these impairment groups. In brief, we highlight the extra caution required to ensure athlete health, performance and sports safety among Para athletes participating in the snow-sport events in the 2022 Beijing Paralympic Games. Although there is an urgent need for more high-quality research focusing on Para winter athletes, we hope these non-consensus recommendations will help prepare for the 2022 Beijing Paralympic Winter Games.
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- Forcina, Giorgio, et al.
(författare)
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Safe design of flow management systems using rebeca
- 2020
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Ingår i: Journal of Information Processing. - : Information Processing Society of Japan. - 0387-5806 .- 1882-6652. ; 28, s. 588-598
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Tidskriftsartikel (refereegranskat)abstract
- Track-based flow management systems like transportation systems and traffic control systems play a crucial role in our daily life. Safety and performance are among the most important quality requirements for these systems. This paper presents AdaptiveFlow as a framework for modeling, safety checking and performance analysis of track-based flow management systems. AdaptiveFlow is based on the Hewitt actors computation model. In particular, tracks are modeled as actors and moving objects as messages. Timed Rebeca is used for modeling, and the model checking tool Afra is used for safety verification and performance evaluation in AdaptiveFlow. To react to dynamic changes in the environment, AdaptiveFlow provides support for three adaptive policies, which can be examined and compared in different scenarios. To demonstrate the applicability of AdaptiveFlow, we consider the Electric Site Research Project of Volvo Construction Equipment as a case study. In this project, a fleet of autonomous haulers is utilized to transport materials in a quarry site. Furthermore, to show the reusability of the framework for other flow management scenarios, an experiment on an urban garbage collection system is presented. © 2020 Information Processing Society of Japan.
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- Li, Jun, et al.
(författare)
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ALPPS for Locally Advanced Intrahepatic Cholangiocarcinoma: Did Aggressive Surgery Lead to the Oncological Benefit? An International Multi-center Study
- 2020
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Ingår i: Annals of Surgical Oncology. - : SPRINGER. - 1068-9265 .- 1534-4681. ; 27, s. 1372-1384
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Tidskriftsartikel (refereegranskat)abstract
- Background ALPPS is found to increase the resectability of primary and secondary liver malignancy at the advanced stage. The aim of the study was to verify the surgical and oncological outcome of ALPPS for intrahepatic cholangiocarcinoma (ICC). Methods The study cohort was based on the ALPPS registry with patients from 31 international centers between August 2009 and January 2018. Propensity score matched patients receiving chemotherapy only were selected from the SEER database as controls for the survival analysis. Results One hundred and two patients undergoing ALPPS were recruited, 99 completed the second stage with median inter-stage duration of 11 days. The median kinetic growth rate was 23 ml/day. R0 resection was achieved in 87 (85%). Initially high rates of morbidity and mortality decreased steadily to a 29% severe complication rate and 7% 90-day morbidity in the last 2 years. Post-hepatectomy liver failure remained the main cause of 90-day mortality. Multivariate analysis revealed insufficient future liver remnant at the stage-2 operation (FLR2) to be the only risk factor for severe complications (OR 2.91, p = 0.02). The propensity score matching analysis showed a superior overall survival in the ALPPS group compared to palliative chemotherapy (median overall survival: 26.4 months vs 14 months; 1-, 2-, and 3-year survival rates: 82.4%, 70.5% and 39.6% vs 51.2%, 21.4% and 11.3%, respectively, p amp;lt; 0.01). The survival benefit, however, was not confirmed in the subgroup analysis for patients with insufficient FLR2 or multifocal ICC. Conclusion ALPPS showed high efficacy in achieving R0 resections in locally advanced ICC. To get the most oncological benefit from this aggressive surgery, ALPPS would be restricted to patients with single lesions and sufficient FLR2.
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