| 1. |
- Klein, Richard J.T., et al.
(författare)
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Risk, vulnerability and adaptation in Europe
- 2009
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Ingår i: Adaptation and Mitigation Strategies. - Norwich, UK : Tyndall Centre for Climate Change Research, University of East Anglia. ; , s. 11-15
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 2. |
- Donovan, Michael J., et al.
(författare)
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Personalized prediction of tumor response and cancer progression on prostate needle biopsy
- 2009
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Ingår i: Journal of Urology. - : Ovid Technologies (Wolters Kluwer Health). - 0022-5347 .- 1527-3792. ; 182:1, s. 125-132
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: To our knowledge in patients with prostate cancer there are no available tests except clinical variables to determine the likelihood of disease progression. We developed a patient specific, biology driven tool to predict outcome at diagnosis. We also investigated whether biopsy androgen receptor levels predict a durable response to therapy after secondary treatment. MATERIALS AND METHODS: We evaluated paraffin embedded prostate needle biopsy tissue from 1,027 patients with cT1c-T3 prostate cancer treated with surgery and followed a median of 8 years. Machine learning was done to integrate clinical data with biopsy quantitative biometric features. Multivariate models were constructed to predict disease progression with the C index to estimate performance. RESULTS: In a training set of 686 patients (total of 87 progression events) 3 clinical and 3 biopsy tissue characteristics were identified to predict clinical progression within 8 years after prostatectomy with 78% sensitivity, 69% specificity, a C index of 0.74 and a HR of 5.12. Validation in an independent cohort of 341 patients (total of 44 progression events) yielded 76% sensitivity, 64% specificity, a C index of 0.73 and a HR of 3.47. Increased androgen receptor in tumor cells in the biopsy highly significantly predicted resistance to therapy, ie androgen ablation with or without salvage radiotherapy, and clinical failure (p <0.0001). CONCLUSIONS: Morphometry reliably classifies Gleason pattern 3 tumors. When combined with biomarker data, it adds to the hematoxylin and eosin analysis, and prostate specific antigen values currently used to assess outcome at diagnosis. Biopsy androgen receptor levels predict the likelihood of a response to therapy after recurrence and may guide future treatment decisions.
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| 3. |
- Murdoch, David R, et al.
(författare)
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Clinical presentation, etiology, and outcome of infective endocarditis in the 21st century: the International Collaboration on Endocarditis-Prospective Cohort Study.
- 2009
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Ingår i: Archives of internal medicine. - : American Medical Association (AMA). - 1538-3679 .- 0003-9926. ; 169:5, s. 463-73
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: We sought to provide a contemporary picture of the presentation, etiology, and outcome of infective endocarditis (IE) in a large patient cohort from multiple locations worldwide. METHODS: Prospective cohort study of 2781 adults with definite IE who were admitted to 58 hospitals in 25 countries from June 1, 2000, through September 1, 2005. RESULTS: The median age of the cohort was 57.9 (interquartile range, 43.2-71.8) years, and 72.1% had native valve IE. Most patients (77.0%) presented early in the disease (<30 days) with few of the classic clinical hallmarks of IE. Recent health care exposure was found in one-quarter of patients. Staphylococcus aureus was the most common pathogen (31.2%). The mitral (41.1%) and aortic (37.6%) valves were infected most commonly. The following complications were common: stroke (16.9%), embolization other than stroke (22.6%), heart failure (32.3%), and intracardiac abscess (14.4%). Surgical therapy was common (48.2%), and in-hospital mortality remained high (17.7%). Prosthetic valve involvement (odds ratio, 1.47; 95% confidence interval, 1.13-1.90), increasing age (1.30; 1.17-1.46 per 10-year interval), pulmonary edema (1.79; 1.39-2.30), S aureus infection (1.54; 1.14-2.08), coagulase-negative staphylococcal infection (1.50; 1.07-2.10), mitral valve vegetation (1.34; 1.06-1.68), and paravalvular complications (2.25; 1.64-3.09) were associated with an increased risk of in-hospital death, whereas viridans streptococcal infection (0.52; 0.33-0.81) and surgery (0.61; 0.44-0.83) were associated with a decreased risk. CONCLUSIONS: In the early 21st century, IE is more often an acute disease, characterized by a high rate of S aureus infection. Mortality remains relatively high.
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| 6. |
- Anderberg, Arne A., et al.
(författare)
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Evolutionary relationships in the Asteraceae tribe Inuleae (incl. Plucheeae) evidenced by DNA sequences of ndhF; with notes on the systematic positions of some aberrant genera
- 2005
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Ingår i: Organisms Diversity & Evolution. - : Elsevier BV. - 1439-6092 .- 1618-1077. ; 5:2, s. 135-146
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Tidskriftsartikel (refereegranskat)abstract
- The phylogenetic relationships between the tribes Inuleae sensu stricto and Plucheeae are investigated by analysis of sequence data from the cpDNA gene ndhF. The delimitation between the two tribes is elucidated, and the systematic positions of a number of genera associated with these groups, i.e. genera with either aberrant morphological characters or a debated systematic position, are clarified. Together, the Inuleae and Plucheeae form a monophyletic group in which the majority of genera of Inuleae s.str. form one clade, and all the taxa from the Plucheeae together with the genera Antiphiona, Calostephane, Geigeria, Ondetia, Pechuel-loeschea, Pegolettia, and Iphionopsis from Inuleae s.str. form another. Members of the Plucheeae are nested with genera of the Inuleae s.str., and support for the Plucheeae clade is weak. Consequently, the latter cannot be maintained and the two groups are treated as one tribe, Inuleae, with the two subtribes Inulinae and Plucheinae. The genera Asteriscus, Chrysophthalmum, Inula, Laggera, Pentanema, Pluchea, and Pulicaria are demonstrated to be non-monophyletic. Cratystylis and Iphionopsis are found to belong to the same clade as the taxa of the former Plucheeae. Caesulia is shown to be a close relative of Duhaldea and Blumea of the Inuleae-Inulinae. The genera Callilepis and Zoutpansbergia belong to the major clade of the family that includes the tribes Heliantheae sensu lato and Inuleae (incl. Plucheeae), but their exact position remains unresolved. The genus Gymnarrhena is not part of the Inuleae, but is either part of the unresolved basal complex of the paraphyletic Cichorioideae, or sister to the entire Asteroideae.
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| 7. |
- Bayer, J., et al.
(författare)
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Service Engineering Methodology
- 2008
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Ingår i: Semantic Service Provisioning. - Berlin : Springer Verlag. - 9783540786160 ; , s. 185-202
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Bokkapitel (refereegranskat)
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| 8. |
- Bayer, K., et al.
(författare)
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Targeted deposition of Au aerosol nanoparticles on vertical nanowires for the creation of nanotrees
- 2007
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Ingår i: Journal of Nanoparticle Research. - : Springer Science and Business Media LLC. - 1572-896X .- 1388-0764. ; 9:6, s. 1211-1216
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Tidskriftsartikel (refereegranskat)abstract
- Complex tree-like nanostructures with controlled morphology are becoming increasingly important for the development of nanoscale devices. The position of branches on III-V semiconductor nanotrees is determined by the distribution of Au seed particles. Here we report the dependence of the distribution of Au aerosol nanoparticles on nanowires on parameters including distance between wires, particle size, wire length, wire diameter, III-V material and particle charge. It was observed that different wire lengths and separation distances as well as different particle polarities have a significant effect on the resulting particle distribution while different wire diameters, particle diameters, materials and deposition voltages do not.
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| 9. |
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| 10. |
- Bayer, R, et al.
(författare)
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Active deformation in Zagros-Makran transition zone inferred from GPS measurements
- 2006
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Ingår i: Geophysical Journal International. ; 165:1, s. 373-381
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Tidskriftsartikel (refereegranskat)abstract
- The Bandar Abbas-Strait of Hormuz zone is considered as a transition between the Zagros collision and the Makran oceanic subduction. We used GPS network measurements collected in 2000 and 2002 to better understand the distribution of the deformation between the collision zone and the Makran subduction. Analysing the GPS velocities, we show that transfer of the deformation is mainly accommodated along the NNW–SSE-trending reverse right-lateral Zendan–Minab–Palami (ZMP) fault system. The rate is estimated to 10 ± 3 mm yr−1 near the faults. Assuming that the ZMP fault system transfers the motion between the Makran–Lut Block and the Arabian plate, we estimate to 15 mm yr−1 and 6 mm yr−1, respectively, the dextral strike-slip and shortening components of the long-term transpressive displacement. Our geodetic measurements suggest also a 10–15 km locking depth for the ZMP fault system. The radial velocity pattern and the orientation of compressive strain axes around the straight of Hormuz is probably the consequence of the subducting Musandam promontory. The N–S Jiroft–Sabzevaran (JS) fault system prolongates southwards the dextral shear motion of the Nayband–Gowk (NG) fault system at an apparent rate of 3.1 ± 2.5 mm yr−1. The change from strong to weak coupling for underthrusting the Arabian plate beneath the Zagros (strong) and the Makran (weak) may explain the dextral motion along the ZMP, JS/NG and Neh–Zahedan fault systems which transfer the convergence from a broad zone in the western Iran (Zagros, Tabriz fault system, Alborz, Caucasus and Caspian sea surroundings) to Makran subduction.
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