| 1. |
- Nishi, Stephanie K., et al.
(författare)
-
Mediterranean, DASH, and MIND Dietary Patterns and Cognitive Function : The 2-Year Longitudinal Changes in an Older Spanish Cohort
- 2021
-
Ingår i: Frontiers in Aging Neuroscience. - : Frontiers Media SA. - 1663-4365. ; 13
-
Tidskriftsartikel (refereegranskat)abstract
- Background and Aims: Plant-forward dietary patterns have been associated with cardiometabolic health benefits, which, in turn, have been related to cognitive performance with inconsistent findings. The objective of this study was to examine the relationship between baseline adherence to three a priori dietary patterns (Mediterranean, DASH, and MIND diets) with 2-year changes in cognitive performance in older adults with overweight or obesity and high cardiovascular disease risk. Methods: A prospective cohort analysis was conducted within the PREDIMED-Plus trial, involving 6,647 men and women aged 55–75 years with overweight or obesity and metabolic syndrome. Using a validated, semiquantitative 143-item food frequency questionnaire completed at baseline, the dietary pattern adherence scores were calculated. An extensive neuropsychological test battery was administered at baseline and 2-year follow-up. Multivariable-adjusted linear regression models were used to assess associations between 2-year changes in cognitive function z-scores across tertiles of baseline adherence to the a priori dietary patterns. Results: Adherence to the Mediterranean diet at baseline was associated with 2-year changes in the general cognitive screening Mini-Mental State Examination (MMSE, β: 0.070; 95% CI: 0.014, 0.175, P-trend = 0.011), and two executive function-related assessments: the Trail Making Tests Part A (TMT-A, β: −0.054; 95% CI: −0.110, − 0.002, P-trend = 0.047) and Part B (TMT-B, β: −0.079; 95% CI: −0.134, −0.024, P-trend = 0.004). Adherence to the MIND diet was associated with the backward recall Digit Span Test assessment of working memory (DST-B, β: 0.058; 95% CI: 0.002, 0.114, P-trend = 0.045). However, higher adherence to the DASH dietary pattern was not associated with better cognitive function over a period of 2 years. Conclusion: In older Spanish individuals with overweight or obesity and at high cardiovascular disease risk, higher baseline adherence to the Mediterranean dietary pattern may be associated with better cognitive performance than lower adherence over a period of 2 years.
|
|
| 2. |
- Bravo-Arrepol, Gastón, et al.
(författare)
-
ISOLATED LIGNANS OF ARAUCARIA ARAUCANA (MOLINA) K. KOCH PROVIDE WOOD PROTECTION AGAINST ATTACK BY THE XYLOPHAGOUS FUNGUS PLEUROTUS OSTREATUS (JACQ.) P. KUMM
- 2023
-
Ingår i: Journal of the Chilean Chemical Society. - 0717-9324. ; 68:2, s. 5871-5875
-
Tidskriftsartikel (refereegranskat)abstract
- Araucaria araucana (Molina) K. Koch is an evergreen conifer endemic of Southern Chile and it is considered a sacred tree by the Pehuenche originary people. A. araucana is endangered in the red book. The knots wood of A. araucana are resistant to biological degradation, due to producing a high amount of lignans, even after the decomposition of the tree is possible to find its knots in the forest. In the present study the chemical composition of three wood tissue of A. araucana; knotwood, stemwood, and branches were analyzed by HPTLC-MS, GC-MS, and NMR. Three lignans were purified and identified as eudesmin (1), ((1S,2R,3R) 1,2,3,4-tetrahydrona phthalene-2,3-diyl) dimethanol (2) and secoisolarisiresinol (3). Folin-Ciocalteu, DPPH and resistance to biodegradation assays were evaluated to extracts from compressed wood zones. Eudesmin was identified as the principal lignan in knots with a 0.5%w/w and outperformed the fungicide Nipacide® P511 in protecting wood against xylophage fungi Pleurotus ostreatus (Jacq.) P. Kumm.
|
|
| 3. |
- de Oliveira e Silva, Jose Claudio, et al.
(författare)
-
EMC considerations for JLRL direct lightning current measurement
- 2022
-
Ingår i: 2022 36Th International Conference On Lightning Protection (ICLP 2022). - : Institute of Electrical and Electronics Engineers (IEEE). ; , s. 26-31
-
Konferensbidrag (refereegranskat)abstract
- In this paper the electromagnetic compatibility (EMC) considerations made to the direct lightning current measuring system that is part of the Johannesburg Lightning Research Laboratory (JLRL) are presented. The output voltages from two series connected shunts and the sending of their analog signals downward a tower to the measuring system, makes this measuring setup particularly critical regarding immunity against the strong effects of the lightning current.
|
|
| 4. |
- Toledo, Estefania, et al.
(författare)
-
Plasma lipidome and risk of atrial fibrillation: results from the PREDIMED trial
- 2023
-
Ingår i: Journal of Physiology and Biochemistry. - 1138-7548 .- 1877-8755. ; 79:2, s. 355-364
-
Tidskriftsartikel (refereegranskat)abstract
- The potential role of the lipidome in atrial fibrillation (AF) development is still widely unknown. We aimed to assess the association between lipidome profiles of the Prevención con Dieta Mediterránea (PREDIMED) trial participants and incidence of AF. We conducted a nested case–control study (512 incident centrally adjudicated AF cases and 735 controls matched by age, sex, and center). Baseline plasma lipids were profiled using a Nexera X2 U-HPLC system coupled to an Exactive Plus orbitrap mass spectrometer. We estimated the association between 216 individual lipids and AF using multivariable conditional logistic regression and adjusted the p values for multiple testing. We also examined the joint association of lipid clusters with AF incidence. Hitherto, we estimated the lipidomics network, used machine learning to select important network-clusters and AF-predictive lipid patterns, and summarized the joint association of these lipid patterns weighted scores. Finally, we addressed the possible interaction by the randomized dietary intervention. Forty-one individual lipids were associated with AF at the nominal level (p < 0.05), but no longer after adjustment for multiple-testing. However, the network-based score identified with a robust data-driven lipid network showed a multivariable-adjusted ORper+1SD of 1.32 (95% confidence interval: 1.16–1.51; p < 0.001). The score included PC plasmalogens and PE plasmalogens, palmitoyl-EA, cholesterol, CE 16:0, PC 36:4;O, and TG 53:3. No interaction with the dietary intervention was found. A multilipid score, primarily made up of plasmalogens, was associated with an increased risk of AF. Future studies are needed to get further insights into the lipidome role on AF. Current Controlled Trials number, ISRCTN35739639.
|
|
