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- Benedikt, M., et al.
(författare)
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Conceptual design report for a Beta-Beam facility
- 2011
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Ingår i: European Physical Journal A. Hadrons and Nuclei. - : Springer Science and Business Media LLC. - 1434-6001. ; 47:2
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Forskningsöversikt (refereegranskat)abstract
- The Beta-Beam is a concept of large-scale facility that aims at providing pure electronic neutrino and antineutrino beams for the measurement of v(e) -> v(mu) oscillations. Beta-decaying nuclides are produced in large amounts in a facility of the scale of EURISOL, and are then post-accelerated and stored at large gamma in a racetrack decay ring. We present here a conceptual design of the accelerator chain of a Beta-Beam based at CERN.
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| 4. |
- Ludvigsson, Johnny, et al.
(författare)
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GAD65 antigen therapy in recently diagnosed type 1 diabetes mellitus
- 2012
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Ingår i: New England Journal of Medicine. - : Massachusetts Medical Society. - 0028-4793 .- 1533-4406. ; 366:5, s. 433-442
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: The 65-kD isoform of glutamic acid decarboxylase (GAD65) is a major autoantigen in type 1 diabetes. We hypothesized that alum-formulated GAD65 (GAD-alum) can preserve beta-cell function in patients with recent-onset type 1 diabetes.METHODS: We studied 334 patients, 10 to 20 years of age, with type 1 diabetes, fasting C-peptide levels of more than 0.3 ng per milliliter (0.1 nmol per liter), and detectable serum GAD65 autoantibodies. Within 3 months after diagnosis, patients were randomly assigned to receive one of three study treatments: four doses of GAD-alum, two doses of GAD-alum followed by two doses of placebo, or four doses of placebo. The primary outcome was the change in the stimulated serum C-peptide level (after a mixed-meal tolerance test) between the baseline visit and the 15-month visit. Secondary outcomes included the glycated hemoglobin level, mean daily insulin dose, rate of hypoglycemia, and fasting and maximum stimulated C-peptide levels.RESULTS: The stimulated C-peptide level declined to a similar degree in all study groups, and the primary outcome at 15 months did not differ significantly between the combined active-drug groups and the placebo group (P=0.10). The use of GAD-alum as compared with placebo did not affect the insulin dose, glycated hemoglobin level, or hypoglycemia rate. Adverse events were infrequent and mild in the three groups, with no significant differences.CONCLUSIONS: Treatment with GAD-alum did not significantly reduce the loss of stimulated C peptide or improve clinical outcomes over a 15-month period.
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| 7. |
- Thompson, Rodger I., et al.
(författare)
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A molecular probe of dark energy
- 2008
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Ingår i: Advances in Space Research. - : Elsevier BV. - 1879-1948 .- 0273-1177. ; 42:3, s. 596-598
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Tidskriftsartikel (refereegranskat)abstract
- Many theoretical models of dark energy invoke rolling scaler fields which in turn predict time varying values of the fundamental constants. Establishing the value of the fundamental constants at various times in the universe can probe and test the various dark energy theories. One of the constants that is predicted to vary is the ratio of the electron to proton mass μ. It was established early on that molecular spectra are sensitive to the value of μ and can be used as probes of that value. This article describes the use of the spectrum of molecular hydrogen in high redshift Damped Lyman Alpha systems (DLAs) as a sensitive probe of the time evolution of μ.
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| 8. |
- Thompson, Rodger I., et al.
(författare)
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Alternative data reduction procedures for UVES: Wavelength calibration and spectrum addition
- 2009
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Ingår i: New Astronomy. - : Elsevier BV. - 1384-1076 .- 1384-1092. ; 14:4, s. 379-390
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Tidskriftsartikel (refereegranskat)abstract
- This paper addresses alternative procedures to the ESO supplied pipeline procedures for the reduction of UVES spectra of two quasar spectra to determine the value of the fundamental constant μ=Mp/Me at early times in the universe. The procedures utilize intermediate product images and spectra produced by the pipeline with alternative wavelength calibration and spectrum addition methods. Spectroscopic studies that require extreme wavelength precision need customized wavelength calibration procedures beyond that usually supplied by the standard data reduction pipelines. An example of such studies is the measurement of the values of the fundamental constants at early times in the universe. This article describes a wavelength calibration procedure for the UV–visual Echelle spectrometer on the very large telescope, however, it can be extended to other spectrometers as well. The procedure described here provides relative wavelength precision of better than 3×10-7 for the long-slit Thorium–Argon calibration lamp exposures. The gain in precision over the pipeline wavelength calibration is almost entirely due to a more exclusive selection of Th/Ar calibration lines.
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| 9. |
- Thompson, Rodger I., et al.
(författare)
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An observational determination of the proton to electron mass ratio in the early Universe
- 2009
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Ingår i: Astrophysical Journal. - 1538-4357 .- 0004-637X. ; 703:2009 October 1, s. 1648 - 1662
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Tidskriftsartikel (refereegranskat)abstract
- In an effort to resolve the discrepancy between two measurements of the fundamental constant μ, the proton to electron mass ratio, at early times in the universe we reanalyze the same data used in the earlier studies. Our analysis of the molecular hydrogen absorption lines in archival Very Large Telescope/Ultraviolet and Visible Echelle Spectrometer (UVES) spectra of the damped Lyman alpha systems in the quasi-stellar objects Q0347-383 and Q0405-443 yields a combined measurement of a Δμ/μ value of (–7 ± 8) × 10–6, consistent with no change in the value of μ over a time span of 11.5 Gyr. Here, we define Δμ as (μ z – μ0) where μ z is the value of μ at a redshift of z and μ0 is the present-day value. Our null result is consistent with the recent measurements of King et al., Δμ/μ = (2.6 ± 3.0) × 10–6, and inconsistent with the positive detection of a change in μ by Reinhold et al. Both of the previous studies and this study are based on the same data but with differing analysis methods. Improvements in the wavelength calibration over the UVES pipeline calibration is a key element in both of the null results. This leads to the conclusion that the fundamental constant μ is unchanged to an accuracy of 10–5 over the last 80% of the age of the universe, well into the matter dominated epoch. This limit provides constraints on models of dark energy that invoke rolling scalar fields and also limits the parameter space of supersymmetric or string theory models of physics. New instruments, both planned and under construction, will provide opportunities to greatly improve the accuracy of these measurements.
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