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| 2. |
- Adams, JM, et al.
(författare)
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Overview of JET results in support of the ITER physics basis
- 2001
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Ingår i: NUCLEAR FUSION. - : INT ATOMIC ENERGY AGENCY. ; 41:10
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- The JET experimental campaign has focused on studies in support of the ITER physics basis. An overview of the results obtained is given for the reference ELMy H mode and advanced scenarios, which in JET are based on internal transport barriers. JET studi
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| 3. |
- Cameron, D., et al.
(författare)
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Replica Management in the European Data Grid Project
- 2004
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Ingår i: Journal of Grid Computing. - 1570-7873 .- 1572-9184. ; 2:4, s. 341-351
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Tidskriftsartikel (refereegranskat)abstract
- Within the European DataGrid project, Work Package 2 has designed and implemented a set of integrated replica management services for use by data intensive scientific applications. These services, based on the web services model, enable movement and replication of data at high speed from one geographical site to another, management of distributed replicated data, optimization of access to data, and the provision of a metadata management tool. In this paper we describe the architecture and implementation of these services and evaluate their performance under demanding Grid conditions.
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| 4. |
- Horikawa, Y, et al.
(författare)
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Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus
- 2000
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 26:2, s. 163-175
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Tidskriftsartikel (refereegranskat)abstract
- Type 2 or non-insulin-dependent diabetes mellitus (NIDDM) is the most common form of diabetes worldwide, affecting approximately 4% of the world's adult population. It is multifactorial in origin with both genetic and environmental factors contributing to its development. A genome-wide screen for type 2 diabetes genes carried out in Mexican Americans localized a susceptibility gene, designated NIDDM1, to chromosome 2. Here we describe the positional cloning of a gene located in the NIDDM1 region that shows association with type 2 diabetes in Mexican Americans and a Northern European population from the Botnia region of Finland. This putative diabetes-susceptibility gene encodes a ubiquitously expressed member of the calpain-like cysteine protease family, calpain-10 (CAPN10). This finding suggests a novel pathway that may contribute to the development of type 2 diabetes.
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| 5. |
- Nesje, M, et al.
(författare)
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Genetic variability in peregrine falcons (Falco peregrinus) analysed by microsatellites.
- 2002
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Ingår i: Raptors in the new Millenium, eds. Yosef,R., Miller, M.L. & Pepler D. International Birding & Research Center in Eilat, Israel.. ; , s. 206-210
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Tidskriftsartikel (refereegranskat)abstract
- Genetic variability and population structure in the endangered Peregrine Falcon (Falco peregrinus) were studied using DNA microsatellite markers. Special emphasis was placed on the subspecies F.p.peregrinus living in Scandinavia and Scotland. The species was almost extirpated as a breeding bird in southeastern Norway and southwestern Sweden in the 1970´s before a recovery programme was initiated. We compared the level of genetic variability of peregrines from the southern area to those found in the northern part of Scandinavia where the decline was less severe. For comparative purposes, three North American peregrine subspecis (F.p.tundrius, F.p.pealei, F.p. anatum) and one Tasmania subspecies (F.p. macropus) were included in this analyses. Twelve DNA microsatellite loci (developed from the peregrine falcon) were analysed across a total of 146 individuals. The amount of genetic variation did not differ in the peregrine populations, except for Tasmania with a significant lower genetic variability. Significant genetic differentiation was found between populations in northern and southern Scandinavia and between the Scandinavian and Scottish populations, while the populations in south-western Norway and south-eastern Sweden did not differ significantly. Analysis of cliff nesting peregrines in northern Sweden and bog nesting peregrines in northern Finland/Sweden suggests that the difference in nesting habitat is not associated with genetic differentiation. Population structuring in F.p.peregrinus is further supported by an assignment test, wherein simulated genotypes are correctly assigned to the northern and southern Scandinavian and Scottish populations with relatively high probabilities, and by analysis of allele-sharing among individuals. Cluster analyses of genetic distances grouped populations of peregrines in accordance with their subspecific designation. F.p.macropus clusters distinctly from the other four subspecies, and peregrines on either side of the Atlantic Ocean were clearly separated. Except for the Tasmanian population, the markers show a high resolving power for parentage and identity analysis, confirming their usefulness as a tool for various research and management purposes over a range of populations and subspecies.
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