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- Perner, Anders, et al.
(författare)
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Hydroxyethyl Starch 130/0.4 versus Ringer's Acetate in Severe Sepsis
- 2012
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Ingår i: New England Journal of Medicine. - 0028-4793 .- 1533-4406. ; 367:2, s. 124-134
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND Hydroxyethyl starch (HES) 130/0.4 is widely used for fluid resuscitation in intensive care units (ICUs), but its safety and efficacy have not been established in patients with severe sepsis. METHODS In this multicenter, parallel-group, blinded trial, we randomly assigned patients with severe sepsis to fluid resuscitation in the ICU with either 6% HES 130/0.4 or Ringer's acetate at a dose of up to 33 ml per kilogram of ideal body weight per day. The primary outcome measure was either death or end-stage kidney failure (dependence on dialysis) at 90 days after randomization. RESULTS Of the 804 patients who underwent randomization, 798 were included in the modified intention-to-treat population. The two intervention groups had similar baseline characteristics. At 90 days after randomization, 201 of 398 patients (51%) assigned to HES 130/0.4 had died, as compared with 172 of 400 patients (43%) assigned to Ringer's acetate (relative risk, 1.17; 95% confidence interval [CI], 1.01 to 1.36; P=0.03); 1 patient in each group had end-stage kidney failure. In the 90-day period, 87 patients (22%) assigned to HES 130/0.4 were treated with renal-replacement therapy versus 65 patients (16%) assigned to Ringer's acetate (relative risk, 1.35; 95% CI, 1.01 to 1.80; P=0.04), and 38 patients (10%) and 25 patients (6%), respectively, had severe bleeding (relative risk, 1.52; 95% CI, 0.94 to 2.48; P=0.09). The results were supported by multivariate analyses, with adjustment for known risk factors for death or acute kidney injury at baseline. CONCLUSIONS Patients with severe sepsis assigned to fluid resuscitation with HES 130/0.4 had an increased risk of death at day 90 and were more likely to require renal-replacement therapy, as compared with those receiving Ringer's acetate.
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- Bendtsen, Marcus, 1928-, et al.
(författare)
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Gated Bayesian Networks
- 2013
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Ingår i: TWELFTH SCANDINAVIAN CONFERENCE ON ARTIFICIAL INTELLIGENCE (SCAI 2013). - Amsterdam : IOS Press. - 9781614993292 ; , s. 35-44
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Konferensbidrag (refereegranskat)abstract
- This paper introduces a new probabilistic graphical model called gated Bayesian network (GBN). This model evolved from the need to represent real world processes that include several distinct phases. In essence a GBN is a model that combines several Bayesian networks (BN) in such a manner that they may be active or inactive during queries to the model. We use objects called gates to combine BNs, and to activate and deactivate them when predefined logical statements are satisfied. These statements are based on combinations of posterior probabilities of the variables in the BNs. Although GBN is a new formalism there are features of GBNs that are similar to other formalisms and research, including influence diagrams, context-specific independence and structural adaptation.
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- Bendtsen, Marcus, et al.
(författare)
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Learning Gated Bayesian Networks for Algorithmic Trading
- 2014
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Ingår i: Probabilistic Graphical Models. - Cham : Springer. - 9783319114323 - 9783319114330 ; , s. 49-64
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Konferensbidrag (refereegranskat)abstract
- Gated Bayesian networks (GBNs) are a recently introduced extension of Bayesian networks that aims to model dynamical systems consisting of several distinct phases. In this paper, we present an algo- rithm for semi-automatic learning of GBNs. We use the algorithm to learn GBNs that output buy and sell decisions for use in algorithmic trading systems. We show how using the learnt GBNs can substantially lower risks towards invested capital, while at the same time generating similar or better rewards, compared to the benchmark investment strat- egy buy-and-hold.
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- Laurell, Katarina, et al.
(författare)
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Migrainous infarction : a Nordic multicenter study
- 2011
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Ingår i: European Journal of Neurology. - : Wiley-Blackwell. - 1351-5101 .- 1468-1331. ; 18:10, s. 1220-1226
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND AND PURPOSE: Migrainous infarction (MI), i.e., an ischemic stroke developing during an attack of migraine with aura is rare and the knowledge of its clinical characteristics is limited. Previous case series using the International Classification of Headache Disorders (ICHD) included <10 cases which make conclusions less valid. This study aimed to describe characteristics and outcome of MI in a larger sample.METHODS: We analyzed demographic data, risk factors, migraine medication, stroke localization, symptoms, and outcome in a sample of 33 patients with MI according to second edition of the ICHD criteria collected from seven Nordic headache clinics.RESULTS: Amongst 33 patients with MI, there were 20 (61%) women and 13 (39%) men with the median age for stroke of 39 (range 19-76) years. Traditional risk factors for stroke were rare compared with Scandinavian young ischemic stroke populations. During the acute phase, 12 (36%) patients used ergotamines or triptans. Stroke was located in the posterior circulation in 27 (82%) patients and cerebellum was involved in 7 (21%). Except in two patients with brainstem infarctions, the outcome was favorable with total recovery or limited residual symptoms.CONCLUSIONS: The prevalence of traditional risk factors was low and the infarctions were predominantly located in posterior circulation territory, supporting theories of migraine specific mechanisms. The outcome was in general favorable.
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