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- Johansson, Jan-Ove, 1955, et al.
(författare)
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Growth hormone (GH) replacement in GH-deficient adults: a crossover trial comparing the effect on metabolic control, well-being and compliance of three injections per week versus daily injections.
- 2003
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Ingår i: Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. - 1096-6374. ; 13:6, s. 306-15
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Tidskriftsartikel (refereegranskat)abstract
- Growth hormone (GH) replacement therapy regimens in adults using daily subcutaneous (sc) injections may not be optimal with respect to carbohydrate and lipid metabolism. The aim of this study was to compare the efficacy of three times weekly injections with daily sc GH injections in terms of serum IGF-I, IGFBPs, lipoprotein levels, serum bone markers, glucose metabolism, body composition, compliance and well-being. Twenty hypopituitary men, 46-76 years, on a course of stable conventional GH replacement therapy for more than 12 months, were included in a 16-week crossover trial. During the first 8 weeks GH was administered three times per week followed by 8 weeks with daily sc injections with the same weekly dose of GH. Fasting serum samples were collected at baseline and on two consecutive days at the end of each 8-week period. Serum IGF-I and IGFBP-3 concentrations were lower both the first and second morning after the last injection during the period with three injections per week. The second morning after the last GH injection in this period the IGF-I/BP-3 ratio, plasma insulin and FFA were lower whereas IGFBP-1 was increased as compared with values obtained during the period with daily injections. Serum Lp(a) levels, body composition, fat distribution, well-being and compliance were not differently affected by the two treatment regimens. These results suggest that the same weekly dose of GH given as three injections per week reduces serum IGF-I and IGFBP-3 levels without affecting Lp(a) levels. The day-to-day variation in glucose metabolism and FFA serum levels differs considerably between the two modes of GH administration.
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- Wigren, Maria, et al.
(författare)
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Atheroprotective effects of Alum are associated with capture of oxidized LDL antigens and activation of regulatory T cells
- 2009
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Ingår i: Circulation Research. - 0009-7330 .- 1524-4571. ; 104:12, s. e62-70
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Tidskriftsartikel (refereegranskat)abstract
- The immune system represents a promising novel target for prevention of atherosclerosis. Several pilot vaccines that reduce atherosclerosis in experimental animals have been developed. The aluminum hydroxide adjuvant Alum has been shown to have antiatherogenic properties in itself, suggesting that it may be a suitable adjuvant in possible future atherosclerosis vaccines. To characterize the immune pathways mediating this protection, we treated wild-type C57BL/6 and Apoe(-)(/)(-) mice with Alum or PBS. Analyses of splenocytes isolated from 12-week-old mice demonstrated that Alum increased the presence of CD4(+)CD25(+)FoxP3(+) regulatory T cells and downregulated the expression of T cell activation markers CD28 and ICOS in Apoe(-)(/)(-) mice but not in C57BL/6 wild-type mice. A similar immunosuppressive phenotype was found also in 25-week-old Apoe(-)(/)(-) mice and was associated with reduced atherosclerosis. Alum precipitates recovered from the injection site of Apoe(-)(/)(-) mice contained antigens derived from oxidized LDL. These findings demonstrate that treatment of Apoe(-)(/)(-) mice with Alum results in an increase of regulatory T cells and suggest that these are activated by tolerogenic antigen-presenting cells presenting oxidized LDL antigens. Our findings provide improved mechanistic understanding of the atheroprotective properties of aluminum hydroxide adjuvants but also point to the importance of determining if hypercholesterolemia may compromise the efficacy of Alum-containing vaccines used clinically today.
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- Aderklou, Christina, et al.
(författare)
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Pedatronics : Robotic toys as a source to evoke young girls’ technological interest
- 2002
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Ingår i: 32nd Annual Frontiers in Education. Leading a Revolution in Engineering and Computer Science Education. - San Diego : Institute of Electrical and Electronics Engineers (IEEE). - 0780374444 ; , s. F1C-19-F1C-24
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Konferensbidrag (refereegranskat)abstract
- This paper presents some results within Pedatronics; a fusion between pedagogics and mechatronics. Our research interest is to study what emerges in the play with robotic toys. Field-experimental studies of 67 year old children’s purposeless play with robotic toys created a self-developmental sphere, as well as evoked young girl’s technological interest. Both girls and boys prolonged and intensified their interest according to the amount of gadgets involved. The results disclose a learning potential, indicating the importance to develop strategies at an early stage in order to encourage girls to choose technological and engineering educations. The study recommend engineers and toy designers, in cooperation with children, to move towards ’Integrated Play Systems’. Due to an ethological method, the results differ from other studies of children’s play with technological advanced artefacts. © 2002 IEEE
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| 7. |
- Alerby, Eva, et al.
(författare)
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Det fysiska rummets betydelse i lärandet
- 2006
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Ingår i: Resultatdialog 2006. - Stockholm : Vetenskapsrådet. - 9173070971 ; , s. 7-15
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 8. |
- Alerby, Eva, et al.
(författare)
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Några nedslag i livsvärlden : teori och praktik i pedagogisk forskning
- 2003
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Forskningsrapporten "Några nedslag i livsvärlden. Teori och praktik i pedagogisk forskning" är resultatet av en forskarutbildningskurs i fenomenologisk livsvärldsforskning som hölls vid Institutionen för lärarutbildning, Luleå tekniska universitet. Kursdeltagarna erbjöds möjligheten att publicera sina texter inom ramen för universitetets forskningsrapportserie. Då kursens deltagare representerar flera olika ämnesområden, såsom lärande, pedagogik, musikpedagogik, idrottspedagogik, hälsovetenskap och social omsorg avspeglar sig detta i de texter som presenteras. Valet av texternas ämnesområden skiljer sig således åt, men samtliga texter förenas i att ämnena är såväl pedagogiska som behandlas med livsvärlden som utgångspunkt.
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- Alerby, Eva, et al.
(författare)
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Reflections on the signification of space in school from a life-world approach
- 2002
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- A school can be regarded from its spatial configuration. These spaces can create expectations and be experienced as inspiring, they can create opportunities but even limitations for the learning of teachers and pupils. Then, what conveys the impression of the spaces? How does the space formation affect the learning process? To what extent do the spaces in school give rise to human relations? What actions and thought space is constituted? A school building can from an architectural starting point be regarded from many perspectives, where perhaps the most prominent are the material characteristics. However, to understand a building only from material characteristics will not give a comprehensive view of the situation. Instead there are also both functional and aesthetic characteristics within a building. Added to that are complicated questions concerning the architecture formation in relation to the human. One way to approach these dimensions, from a scientific perspective, is to take the phenomenological movement as a point of departure, and to be more precise - the phenomenology of the life-world. We claim that it is possible to study and to make a theoretical set of concepts of the meaning of space within learning. This paper will discuss these questions from a life-world approach.
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