| 1. |
- Andraos, Rama, et al.
(författare)
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Autoantibodies associated with systemic sclerosis in three autoimmune diseases imprinted by type I interferon gene dysregulation: a comparison across SLE, primary Sjogrens syndrome and systemic sclerosis
- 2022
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Ingår i: Lupus Science and Medicine. - : BMJ PUBLISHING GROUP. - 2053-8790. ; 9:1
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Tidskriftsartikel (refereegranskat)abstract
- ObjectiveSLE, primary Sjogrens syndrome (pSS) and systemic sclerosis (SSc) are heterogeneous autoimmune diseases with a dysregulated type I interferon (IFN) system. The diseases often show overlapping clinical manifestations, which may result in diagnostic challenges. We asked to which extent SSc-associated autoantibodies are present in SLE and pSS, and whether these link to serum IFN-alpha, clinical phenotypes and sex. Samples with clinical data from patients with SSc and healthy blood donors (HBDs) served as controls. Finally, the diagnostic performance of SSc-associated autoantibodies was evaluated.MethodsSamples from well-characterised subjects with SLE (n=510), pSS (n=116), SSc (n=57) and HBDs (n=236) were analysed using a commercially available immunoassay (EuroLine Systemic Sclerosis Profile (IgG)). IFN-alpha was quantified by ELISA. Self-reported data on Raynauds phenomenon (RP) were available.ResultsWith exceptions for anti-Ro52/SSA and anti-Th/To, SSc-associated autoantibodies were more frequent in SSc than in SLE, pSS and HBDs regardless of sex. IFN-alpha levels correlated with the number of positive SSc-associated autoantibodies (r=0.29, p<0.0001) and associated with Ro52/SSA positivity (p<0.0001). By using data from SLE, SSc and HBDs, RP was significantly associated with topoisomerase I, centromere protein (CENP)-B, RNA polymerase III 11 kDa, RNA polymerase III 155 kDa and PM-Scl100 whereas Ro52/SSA associated inversely with RP. In SLE, CENP-A was associated with immunological disorder, CENP-B with serositis and Ku with lupus nephritis. By combining analysis of ANA (immunofluorescence) with SSc-associated autoantibodies, the diagnostic sensitivity reached 98% and the specificity 33%.ConclusionsThe 13 specificities included in the EuroLine immunoassay are commonly detected in SSc, but they are also frequent among individuals with other diseases imprinted by type I IFNs. These findings are valuable when interpreting serological data on patients with suspected SSc, especially as patients may present with disease manifestations overlapping different rheumatological diseases. In SLE, we observed associations between manifestations and SSc-associated autoantibodies which have not previously been reported.
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| 3. |
- Bengtsson, Rhodel, et al.
(författare)
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A basic orthotropic viscoelastic model for composite and wood materials considering available experimental data and time-dependent Poisson's ratios
- 2020
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Ingår i: IOP Conference Series. - : IOP Publishing. - 1757-8981 .- 1757-899X. ; 942
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Tidskriftsartikel (refereegranskat)abstract
- Long-term deformation in creep is of significant engineering importance. For anisotropic materials, such as wood, composites and reinforced concrete, creep testing in several axial directions including shear is necessary to obtain a creep model which is able to predict deformation in the basic orthotropic case. Such a full set of experimental data is generally not available, and simplifying assumptions are typically made to conceive a useful 3D model. These assumptions should preferably be made based on the material behaviour and sound engineering arguments. This problem appears to be addressed in many different ways and sometimes the assumptions are not well justified. In the present study, we examine 3D creep of wood and composite materials. Particular emphasis is made on explaining the choices made in developing the model, considering practicality, incomplete material data and the specific behaviour of wood and composites. An orthotropic linear viscoelastic model is implemented as a material model in a commercial FE software. The constitutive equations are derived in the 1D case using a hereditary approach, then later generalized to the 3D formulation. Guidelines are shown how to implement it into the FE software to predict creep of components and structures. Although the model itself is conventional, the effect of considering time-dependent Poisson's ratios is investigated here, as well an optimization approach when inserting inevitably asymmetric experimental creep data into the model. As far as the authors know, creep of wooden materials have not been defined using this approach before. The model of interest is calibrated against experimental data. Examples using experimental results from solid wood data and a unidirectional fiber composite are demonstrated. The results show that the model is able to capture the orthotropic behaviour adequately. Orthotropy requires symmetry of the creep compliance matrix, which typically is not the case experimentally. It is shown that in rendering the matrix symmetric, one needs to decide which direction is more important. It is also shown that the frequently employed assumption of constant Poisson's ratios should be made with caution.
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| 4. |
- Bengtsson, Rhodel, et al.
(författare)
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An applicable orthotropic creep model for wood materials and composites
- 2022
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Ingår i: Wood Science and Technology. - : Springer Nature. - 0043-7719 .- 1432-5225. ; 56:6, s. 1585-1604
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Tidskriftsartikel (refereegranskat)abstract
- Despite the engineering importance of creep of composite materials and other fibrous anisotropic load-carrying materials like wood, there is an apparent lack in useful experimental data in 3D. Proposed creep models are generally not commensurate with realistic data from experimental characterization. In the present study, an orthotropic linear viscoelastic model is presented and examined on its performance of predicting the time-dependent nature of wood and composite materials. The constitutive equations are presented using the hereditary approach. A clear description of the finite element implementation of the material model is given. Since constant Poisson's ratios are a common assumption for viscoelastic composites due to lack of data, this study presents the effects of time-dependent Poisson's ratio in the study. The model is calibrated against inevitably asymmetric experimental creep data using an optimization approach. With time-dependent Poisson's ratios, the results show that the model is able to simultaneously capture the time-dependent behaviour in three material axis of orthotropic materials such as European beech wood and a fibre-reinforced composite. However, a relatively poor match was found when the Poisson's ratios were set to be constant. Thus, the frequently employed assumption of constant Poisson's ratios should be made with caution.
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| 5. |
- Bengtsson, Rhodel
(författare)
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Creep aspects of softwood from the cell-wall level to structures
- 2023
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis addresses the intricate mechanical behaviour of natural materials, with a particular focus on wood. Despite millennia of use, understanding the mechanical behaviour of wood materials remains challenging due to their complex microstructures. For instance, they exhibit variations in properties among samples, nonlinear behaviour under elevated loads, and are sensitive to alterations in moisture content.Wood and related natural biobased materials hold immense potential due to their renewability, cost-effectiveness, eco-friendliness, and ease of use in sustainable construction. Wood boasts remarkable stiffness and strength along its primary axis, surpassing many man-made materials in strength-to-weight ratios. However, its anisotropic and heterogeneous nature gives rise to challenges, necessitating the consideration of multiple parameters for accurate characterization to be used in design.Wood is intrinsically heterogeneous, leading to considerable variations in local stresses and deformations during loading. To address these microstructural effects on macroscopically measurable phenomena, mathematical homogenization methods, established since the 1970s, have found applications in material mechanics, including both fibre composites and wood.In recent years, there has been a growing focus on the viscoelastic behaviour of composites and timber structures, given their increased long-term use in load-carrying applications. While numerous investigations have explored the relationship between the microstructure of wood and its elastic properties, few studies have explored the connection between microstructure and viscoelastic properties.The thesis focuses on the static and, more notably, on the time-dependent mechanical properties of wood, bridging the gap from cell-wall creep to structures. It includes experiments and numerical work, culminating in the development of a material model suitable for orthotropic materials like wood. The multiscale model establishes a link between microstructural parameters and macroscopic properties, potentially applicable to various softwood species. Given the lack of shear creep data in the literature, the thesis introduces straightforward methods to characterize shear creep properties, addressing a significant knowledge gap.Furthermore, the thesis progresses from material-level experiments to higher length scales, demonstrating how the results can be applied to larger wooden structures, such as the tower for a counter-rotating axis tilted turbine. While these results require further validation in the absence of experimental data for wooden wind turbine structures, they offer useful insights into simulating creep behaviour in such applications.In conclusion, this thesis highlights the multifaceted nature of a natural material like wood, its mechanical challenges, and the promising research avenues for comprehensive understanding and practical use. The outcome provides contributions to the efficient utilization of wood in load-carrying structures and underlines the importance of ongoing research in this field.
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| 6. |
- Bengtsson, Rhodel, et al.
(författare)
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Evaluating the viscoelastic shear properties of clear wood via off-axis compression testing and digital-image correlation
- 2023
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Ingår i: Mechanics of time-dependant materials. - 1385-2000 .- 1573-2738.
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Tidskriftsartikel (refereegranskat)abstract
- Highly anisotropic materials like wood and unidirectional polymer composite structures are sensitive to shear deformations, in particular close to fixed joints. Large wooden structures in buildings and, e.g. wind-turbine blades, are designed to last for decades, and hence are susceptible to unwanted creep deformations. For improved structural design, the shear-creep properties of the material are needed. These are rarely available in the literature, possibly because of technical difficulties to achieve a well-defined shear-stress state in test specimens. For cost-efficient testing, this goal of a pure stress state necessarily needs to be compromised. In the present study, we propose a simple test method based on uniaxial compression on wooden cubes, but is equally applicable for fibre composites. The viscoelastic shear properties of Norway spruce (Picea abies) under off-axis creep compression tests have been characterised in all three directions. The tests are performed in a controlled climate chamber and the creep strains are captured using digital-image correlation.
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| 8. |
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| 9. |
- Bengtsson, Rhodel, et al.
(författare)
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Viscoelastic behavior of softwood based on a multiscale computational homogenization
- 2023
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Ingår i: Mechanics of materials. - : Elsevier. - 0167-6636 .- 1872-7743. ; 179
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Tidskriftsartikel (refereegranskat)abstract
- In the present study, a numerical multiscale model is made to show how the hierarchical structure of softwood affect its macroscopic viscoelastic properties. The performance of the model is demonstrated for two softwood species — Norway spruce and Japanese cypress, whose creep behavior has been characterized experimentally. The results show that by using the same transversely isotropic viscous properties of the cell wall for both species, it is possible to predict creep deformation relatively close to experimental creep measurements for both species. Assuming that the variability is larger on the microstructural level (density, cell-wall geometry, microfibril angle, composition of wood tissues) than on the cell-wall level, it is possible to predict the macroscopic creep behavior based on the microstructural parameters alone. Such predictions can potentially save cost and time, since creep characterization in all material directions is demanding.
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| 10. |
- Dahl, Martin, 1984, et al.
(författare)
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Application of the sequence planner control framework to an intelligent automation system with a focus on error handling
- 2021
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Ingår i: Machines. - : MDPI AG. - 2075-1702. ; 9:3
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Tidskriftsartikel (refereegranskat)abstract
- Future automation systems are likely to include devices with a varying degree of autonomy, as well as advanced algorithms for perception and control. Human operators will be expected to work side by side with both collaborative robots performing assembly tasks and roaming robots that handle material transport. To maintain the flexibility provided by human operators when introducing such robots, these autonomous robots need to be intelligently coordinated, i.e., they need to be supported by an intelligent automation system. One challenge in developing intelligent automation systems is handling the large amount of possible error situations that can arise due to the volatile and sometimes unpredictable nature of the environment. Sequence Planner is a control framework that supports the development of intelligent automation systems. This paper describes Sequence Planner and tests its ability to handle errors that arise during execution of an intelligent automation system. An automation system, developed using Sequence Planner, is subjected to a number of scenarios where errors occur. The error scenarios and experimental results are presented along with a discussion of the experience gained in trying to achieve robust intelligent automation.
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