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- Abdel-Motal, Ussama M., et al.
(författare)
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Major histocompatibility complex class I binding glycopeptides for the estimation of 'empty' class I molecules
- 1995
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Ingår i: Journal of Immunological Methods. - : Elsevier BV. - 0022-1759. ; 188:1, s. 21-31
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Tidskriftsartikel (refereegranskat)abstract
- Different forms of major histocompatibility complex (MHC) class I heavy chains are known to be expressed on the cell surface, including molecules which are functionally 'empty'. Direct peptide binding to cells is obvious during sensitization of target cells in vitro for cytotoxic T lymphocyte killing and 'empty' MHC-I molecules are comparatively abundant on TAP- 1 2 peptide transporter mutant cells. In the present work we have estimated the fraction of 'empty' MHC class I molecules using glycosylated peptides and cellular staining with carbohydrate specific monoclonal antibodies. Synthetic Db and Kb binding peptides were coupled at different positions with different di- or trisaccharides, using different spacing between the carbohydrate and the peptide backbone. Binding of sugar specific mAbs was compared in ELISA and cellular assays. An optimal Db binding glycopeptide was used for comparative staining with anti-Db and anti-carbohydrate monoclonal antibodies to estimate fractions of 'empty' molecules on different T lymphoid cells. On activated normal T cells, a large fraction of Db molecules were found to be 'empty'. The functional cole of such 'empty' MHC class I molecules on T cells is presently unclear. However, on antigen presenting cells they might participate in the antigen presentation process.
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| 6. |
- Berg, Gösta, et al.
(författare)
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Greta Arwidsson 85 år
- 1991
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Ingår i: Fornvännen. - 0015-7813 .- 1404-9430. ; , s. 91-97
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 7. |
- Berg, Hans-Yngve, et al.
(författare)
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Learner drivers and lay instruction : how socio-economic standing and lifestyle are reflected in driving practice from the age of 16
- 1999
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Ingår i: Transportation Research Part F: Traffic Psychology and Behaviour. - 1369-8478. ; 2:3, s. 167-179
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Tidskriftsartikel (refereegranskat)abstract
- On September 1st 1993, a new law came into effect in Sweden, permitting instructor-supported driving practice from the age of 16 instead of 17 years and 6 months. The intention was to enable young people to gain more experience of driving a car before they acquire a driver's permit and thereby to reduce their accident risk. The study was conducted by means of a questionnaire posted to 601 17-year-olds throughout Sweden. The participants were analysed concerning gender, socio-economic standing (blue-collar and white-collar), and lifestyle (friend-oriented, externally-oriented and parent-oriented). The results show that men obtain a learner's permit more often than women (67.4% vs 57.2%) and that youngsters in white-collar families acquire a learner's permit in more cases than those in blue-collar families (67.4% vs 52.4%). One of the reasons for the latter group not acquiring a permit is that they cannot afford it, while children in white-collar families state that they have neither the time nor the desire. No significant difference was found between the three lifestyle groups. When it comes to the amount of practice, the men have been out on the road on average 39.9 h during their first 13 months, compared to 19.9 h for the women. In the lifestyle groups, those who belong to the so-called externally-oriented lifestyle have practised most. They have reported 39.2 h compared to the parent-oriented group with the least amount of training, 27.9 h on average. The friend-oriented group has 22.2 h of practice. When both lifestyle and socio-economic standing were considered, even greater differences were found. The white-collar group of the externally-oriented lifestyle reported as much as 51.5 h, compared to the blue-collar group of the parent-oriented lifestyle with only 18.4 h of practising. The above result is important because it is not in accordance with the intentions of the new driving practice system. The idea behind the new system was that all young people should have the opportunity for a longer period of driving practice in order to reduce the high accident risk during the first year with a driver’s license. If it is impossible for certain groups of youngsters to start their driving practice at the age of 16, the situation will become socially unjust and measures must be taken to remedy this situation.
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| 9. |
- Berg, Jan-Erik, et al.
(författare)
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A Micromechanical Model of the Deterioration of a Wood Fibre
- 1999
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Ingår i: Journal of Pulp and Paper Science. - 0826-6220. ; 25:2, s. 66-71
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Tidskriftsartikel (refereegranskat)abstract
- A simple analytical model is presented in this paper for the prediction of the stiffness degradation and the damage state in a wood fibre, loaded in uniaxial tension or shear. The model is based on an assumed displacement field together with the minimum total potential energy theorem. For the damage development, an energy criterion is employed. The model is applied to a specific example and the relevant stiffness coefficients are calculated as a function of the damage state. The damage development as a function of the applied loads is also given. The results from a specific example considered indicate that a tensile load affects the stiffness degradation to a larger extent than does a shear load.
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