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- Berg, OG, et al.
(författare)
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Fluctuations in repressor control: Thermodynamic constraints on stochastic focusing
- 2000
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Ingår i: BIOPHYSICAL JOURNAL. - : BIOPHYSICAL SOCIETY. - 0006-3495. ; 79:6, s. 2944-2953
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Tidskriftsartikel (refereegranskat)abstract
- The influence of fluctuations in molecule numbers on genetic control circuits has received considerable attention. The consensus has been that such fluctuations will make regulation less precise. In contrast, it has more recently been shown that signal fl
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- Berg, OG, et al.
(författare)
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Why mitochondrial genes are most often found in nuclei
- 2000
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Ingår i: MOLECULAR BIOLOGY AND EVOLUTION. - : SOC MOLECULAR BIOLOGY EVOLUTION. - 0737-4038. ; 17:6, s. 951-961
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Tidskriftsartikel (refereegranskat)abstract
- A very small fraction of the proteins required for the propagation and function of mitochondria are coded by their genomes, while nuclear genes code the vast majority. We studied the migration of genes between the two genomes when transfer mechanisms medi
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- Paulsson, J, et al.
(författare)
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Stochastic focusing: Fluctuation-enhanced sensitivity of intracellular regulation
- 2000
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Ingår i: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. - : NATL ACAD SCIENCES. - 0027-8424. ; 97:13, s. 7148-7153
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Tidskriftsartikel (refereegranskat)abstract
- Many regulatory molecules are present in low copy numbers per cell so that significant random fluctuations emerge spontaneously. Because cell viability depends on precise regulation of key events, such signal noise has been thought to impose a threat that
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