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- Berg, Frida, et al.
(author)
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The uncoupling protein 1 gene (UCP1) is disrupted in the pig lineage : A genetic explanation for poor thermoregulation in piglets
- 2006
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In: PLoS Genetics. - : Public Library of Science (PLoS). - 1553-7390 .- 1553-7404. ; 2:8, s. 1178-1181
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Journal article (peer-reviewed)abstract
- Piglets appear to lack brown adipose tissue, a specific type of fat that is essential for nonshivering thermogenesis in mammals, and they rely on shivering as the main mechanism for thermoregulation. Here we provide a genetic explanation for the poor thermoregulation in pigs as we demonstrate that the gene for uncoupling protein 1 (UCP1) was disrupted in the pig lineage. UCP1 is exclusively expressed in brown adipose tissue and plays a crucial role for thermogenesis by uncoupling oxidative phosphorylation. We used long-range PCR and genome walking to determine the complete genome sequence of pig UCP1. An alignment with human UCP1 revealed that exons 3 to 5 were eliminated by a deletion in the pig sequence. The presence of this deletion was confirmed in all tested domestic pigs, as well as in European wild boars, Bornean bearded pigs, wart hogs, and red river hogs. Three additional disrupting mutations were detected in the remaining exons. Furthermore, the rate of nonsynonymous substitutions was clearly elevated in the pig sequence compared with the corresponding sequences in humans, cattle, and mice, and we used this increased rate to estimate that UCP1 was disrupted about 20 million years ago.
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| 2. |
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| 3. |
- Hellström, Anna-Lena, 1946, et al.
(author)
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Feeling good in daily life: from the point of view of boys with posterior urethral valves
- 2006
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In: J Urol. - 0022-5347. ; 176:4 Pt 2, s. 1742-6
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Journal article (peer-reviewed)abstract
- PURPOSE: We determined what is important to feel good in daily life when living with a long-term illness that requires daily treatment routines. MATERIALS AND METHODS: Seven boys between 6 and 16 years old who were born with posterior urethral valves narrated their experiences with daily life. They were on clean intermittent catheterization, had impaired renal function and 2 had undergone transplantation. RESULTS: Being involved in decisions about themselves was important, as was having their own doctor and nurse. Friends were important. Clean intermittent catheterization was something that worried them in relation to friends and made them feel uncertain about how they would react to it. The boys accepted the catheterization procedure as something that had to be done but they needed strategies to be able to comply. A single event, such as no available toilet, was enough to interrupt treatment. CONCLUSIONS: In these boys prescribed treatment was a surprisingly small part of their lives. The clean intermittent catheterization routine was sometimes experienced as an obstacle in company with friends. The new challenge might be to achieve compliance with the treatment routine in daily life in a long-term perspective.
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| 5. |
- Paerregaard, Karsten, 1952, et al.
(author)
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Introducción
- 2005
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In: EL QUINTO SUYO: Transnacionalidad y formaciones diaspóricas en la migración peruana. - Lima, Peru : Instituto de Estudios Peruanos. - 9972511367 ; , s. 11-34
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Book chapter (peer-reviewed)
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