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- Björk, Ann-Kristin, et al.
(author)
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Occupational allergic contact dermatitis to gloves, follow-up of investigated patients
- 2014
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In: Contact Dermatitis. - : Wiley. - 0105-1873. ; 70:Suppl s1, s. 94-94
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Conference paper (other academic/artistic)abstract
- Background: In the Department of Occupational and Environmental Dermatology there has been an increase in the inflow of patients, working as surgical nurses or surgeons. They have been referred due to presumed occupational contact dermatitis. Results from investigated patients have in part been presented previously, where the investigation has shownmultiple contact allergies caused by their occupational use of gloves. Allergens such as diphenylguanidine were found in the gloves and contact allergies to their rubber gloves were found. Many of the patients have been working for decades in their present occupation, but the hand dermatitis had often been present for less than a year. Objectives: To present a follow-up of patientswith hand dermatitis due to gloves. Methods: A follow-up of the patients and a structure for the investigation of the individual patient are given. Results: The cases will be presented with their contact allergies, howtheinvestigation isperformedandtheoutcomeof theprevention by avoiding gloves containing the allergens diagnosed in the individual patients. Conclusions: For health care personnel hand hygiene and the wearing of protective gloves are mandatory. Our findings indicate that the increased need to use rubber gloves and at the same time the exclusion of latex gloves give rise to new contact allergies which are clinically relevant. In the investigation, and the advice given to the patients, several factors have to be taken into consideration, including the fast change of glove material. The cases indicate the importance of close cooperation between chemists and dermatologists and the possibility to perform chemical analysis. Furthermore, and just as important for this patient group, is that with correct diagnosis and advice the contact dermatitis can actually heal completely and the patients continue in their work.
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| 3. |
- Hamnerius, Nils, et al.
(author)
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Factors influencing the skin exposure to diphenylguanidine in surgical gloves
- 2014
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In: Contact Dermatitis. - : Wiley. - 0105-1873. ; 70:Suppl s1, s. 59-60
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Conference paper (other academic/artistic)abstract
- Background: For health care personnelhandhygieneandwearing appropriate protective gloves are compulsory. We have noticed an increase of hand eczema caused by contact allergy from rubber chemicals such as diphenylguanidine (DPG) in synthetic rubber gloves used by surgeons and surgical nurses. The exposure time to surgical gloves as well as the number of gloves used per day vary. Furthermore surgery very often includes the use of skin disinfectants before glove donning. Objectives: Does the exposure time influence the amount of DPG released from the gloves? Does the exposure of skin disinfectants before glove donning influence the release of DPG? Methods: Using synthetic sweat, the amount of DPG released from the inside of the gloves at different timeswas measured by HPLC. The remaining extractable DPG was estimated by washing the inside of the gloves with ethanol (50% in water) for 10min. The amount of DPG found on the hands exposed to 3ml skin disinfectant allowed to dry prior to glove donning was compared to the amount found on unexposed hands. After wearing gloves for 60 min the handswerewashedwith ethanol and the amount of DPG recovered was analysed with HPLC. Results: After 10, 30, 60 and 180 min approximately 73%, 79%, 82%, 87% of the total amount of DPG was released. For all comparisons the amount of DPG released was higher on the hand exposed to disinfectants compared with the unexposed hand. Conclusions: A comparatively short exposure time to gloves (10min) implies a substantial exposure to DPG. Thus, repeated usage of glovesmight enhance skin exposure to this rubber chemical. Skin disinfectants does increase the amount of DPG released from the gloves. Thus, possibly the components of the disinfectant remaining on the skin or some othermechanism add to the exposure to DPG.
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| 6. |
- Pontén, Ann, et al.
(author)
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Occupational allergic contact dermatitis caused by sterile non-latex protective gloves: clinical investigation and chemical analyses.
- 2012
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In: Contact Dermatitis. - : Wiley. - 0105-1873.
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Journal article (peer-reviewed)abstract
- Background An increased frequency of occupational contact hand dermatitis among surgical operating theatre personnel has been noticed. Objectives To evaluate patients with occupational contact dermatitis caused by their rubber gloves, and to describe a method for analysing the content of the allergens in the gloves. Materials and methods Patch tests were performed with the baseline series, a rubber chemical series, and the patients' own gloves. A method for analysing 1,3-diphenylguanidine (DPG) and cetylpyridinium chloride in the gloves was developed. Results Contact allergy to thiuram mix was found in 8 of 16 patients, whereas 12 of 16 patients reacted to DPG. In 7 of 8 patients, contact allergy to cetylpyridinium chloride was found. In the patients' gloves, cetylpyridinium chloride and DPG were detected at higher concentrations on the inside of the gloves than on the outside. Most patients had worked for decades in their present occupations, but their hand dermatitis had only been present for months. Conclusion Contact allergy to DPG in gloves has been disputed, but, in this study, we were able to confirm the presence of DPG and cetylpyridinium chloride in the causative gloves by using a modified method for the analysis. The presence of these chemicals in gloves caused an increase in occupational contact dermatitis in surgical operating theatre personnel.
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