| 1. |
- Aronsson, Mora, et al.
(författare)
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Sveriges arter och naturtyper i EU:s art- och habitatdirektiv : Resultat från rapportering 2019 till EU av bevarandestatus 2013-2018
- 2020
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Sverige har en variationsrik natur med storslagen fjällmiljö, myllrande våtmarker, vattendrag och sjöar, kust och hav, skogar och odlingslandskap, alla med ett rikt växt och djurliv. Den här fantastiska biologiska mångfalden tas ofta för given och ibland som en lyx, men oavsett vilket är det en förutsättning för vår överlevnad.2019 rapporterade Sverige statusen till EU för perioden 2013–2018 för de naturtyper och arter i Sverige som är listade i art- och habitatdirektivet. Den berättar att 20 procent av naturtyperna och 40 procent av arterna mår bra. Den biologiska mångfalden är hårt trängd i såväl Sverige som i andra EU-länder.Den här rapporten sammanfattar Sveriges rapportering och innehåller beskrivningar av status för naturtyper och arter, påverkan, hot och trender. Rapporten ger kunskap om tillståndet för den biologiska mångfalden i Sverige med hjälp av de arter och naturtyper som är listade i EU:s art- och habitatdirektiv.Rapporten visar hur naturmiljöerna i Sverige förändas, och sammanfattar den senaste kunskapen om vilka faktorer som driver dessa förändringar. Även exempel på hur vi genom restaurerings- och skötselåtgärder kan hejda förlusten av biologisk mångfald tas upp.
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| 2. |
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| 3. |
- Berglund, Eva Caroline, et al.
(författare)
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A Study Protocol for Validation and Implementation of Whole-Genome and -Transcriptome Sequencing as a Comprehensive Precision Diagnostic Test in Acute Leukemias
- 2022
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Ingår i: Frontiers in Medicine. - Lausanne, Switzerland : Frontiers Media SA. - 2296-858X. ; 9, s. 1-9
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Tidskriftsartikel (refereegranskat)abstract
- Background: Whole-genome sequencing (WGS) and whole-transcriptome sequencing (WTS), with the ability to provide comprehensive genomic information, have become the focal point of research interest as novel techniques that can support precision diagnostics in routine clinical care of patients with various cancer types, including hematological malignancies. This national multi-center study, led by Genomic Medicine Sweden, aims to evaluate whether combined application of WGS and WTS (WGTS) is technically feasible and can be implemented as an efficient diagnostic tool in patients with acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). In addition to clinical impact assessment, a health-economic evaluation of such strategy will be performed. Methods and Analysis: The study comprises four phases (i.e., retrospective, prospective, real-time validation, and follow-up) including approximately 700 adult and pediatric Swedish AML and ALL patients. Results of WGS for tumor (90×) and normal/germline (30×) samples as well as WTS for tumors only will be compared to current standard of care diagnostics. Primary study endpoints are diagnostic efficiency and improved diagnostic yield. Secondary endpoints are technical and clinical feasibility for routine implementation, clinical utility, and health-economic impact. Discussion: Data from this national multi-center study will be used to evaluate clinical performance of the integrated WGTS diagnostic workflow compared with standard of care. The study will also elucidate clinical and health-economic impacts of a combined WGTS strategy when implemented in routine clinical care. Clinical Trial Registration: [https://doi.org/10.1186/ISRCTN66987142], identifier [ISRCTN66987142].
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| 4. |
- Berglund, Erik, et al.
(författare)
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Effects of apixaban compared with warfarin as gain in event-free time : a novel assessment of the results of the ARISTOTLE trial
- 2020
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Ingår i: European Journal of Preventive Cardiology. - : Oxford University Press (OUP). - 2047-4873 .- 2047-4881. ; 27:12, s. 1311-1319
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: A novel approach to determine the effect of a treatment is to calculate the delay of event, which estimates the gain of event-free time. The aim of this study was to estimate gains in event-free time for stroke or systemic embolism, death, bleeding events, and the composite of these events, in patients with atrial fibrillation randomized to either warfarin or apixaban in the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation trial (ARISTOTLE).DESIGN: The ARISTOTLE study was a randomized double-blind trial comparing apixaban with warfarin.METHODS: Laplace regression was used to estimate the delay in time to the outcomes between the apixaban and the warfarin group in 6, 12, 18 and 22 months of follow-up.RESULTS: The gain in event-free time for apixaban versus warfarin was 181 (95% confidence interval 76 to 287) days for stroke or systemic embolism and 55 (-4 to 114) days for death after 22 months of follow-up. The corresponding gains in event-free times for major and intracranial bleeding were 206 (130 to 281) and 392 (249 to 535) days, respectively. The overall gain for the composite of all these events was a gain of 116 (60 to 171) days.CONCLUSIONS: In patients with atrial fibrillation, 22 months of treatment with apixaban, as compared with warfarin, provided gains of approximately 6 months in event-free time for stroke or systemic embolism, 7 months for major bleeding and 13 months for intracranial bleeding.
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| 5. |
- Berglund, Johan C, 1978, et al.
(författare)
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Detailed evaluation of topographical effects of Hirtisation post-processing on electron beam powder bed fusion (PBF-EB) manufactured Ti-6Al-4V component
- 2024
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Ingår i: Precision Engineering. - : Elsevier Inc.. - 0141-6359 .- 1873-2372. ; 85, s. 319-327
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Tidskriftsartikel (refereegranskat)abstract
- Metal additive manufacturing surface topographies are complex and challenging to characterise due to e.g. steep local slopes, re-entrant features, varying reflectivity and features of interest in vastly different scale ranges. Nevertheless, average height parameters such as Ra or Sa are commonly used as sole parameters for characterisation. In this paper, a novel method for selecting relevant parameters for evaluation is proposed and demonstrated using a case study where the smoothing effects after three processing steps of the electro chemical post-process Hirtisation of a metal AM surface are quantified. The method uses a combination of conventional areal texture parameters, multiscale analysis and statistics and can be used to efficiently achieve a detailed and more relevant surface topography characterisation. It was found that the three process steps have different effects on the surface topography regarding the types and sizes of features that were affected. In total, Sdq was reduced by 97 %, S5v was reduced by 81 % and Sa was reduced by 78 %. A surface texture with much lower average roughness, less deep pits and less steep slopes was produced, which is expected to be beneficial for improved fatigue properties.
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| 6. |
- Berglund, Sara, et al.
(författare)
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The Water Mass Transformation in the Upper Limb of the Overturning Circulation in the Southern Hemisphere
- 2021
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Ingår i: Journal of Geophysical Research - Oceans. - 2169-9275 .- 2169-9291. ; 126:8
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Tidskriftsartikel (refereegranskat)abstract
- The warming and salinification of the northwards flowing water masses from the Southern Ocean to the tropics are studied with Lagrangian trajectories simulated using fields from an Earth System Model. The trajectories are used to trace the geographical distribution of the water mass transformation and connect it with the pathways of the upper limb of the overturning circulation in the Southern Hemisphere. In the Antarctic Circumpolar Current water gains heat just below the mixed layer, mainly when the layer is thin during Austral spring and summer. This gain is therefore suggested to be a consequence of heat flux from the atmosphere and mixing processes at the base of the mixed layer. In the Southern Hemispheric subtropical gyres on the other hand, a large warming and salinification of the northwards flowing water results from internal mixing with other warmer and more saline water masses. Close to the Antarctic shelf waters are getting fresher as a result of ice melting, whereas further north, in the Antarctic Circumpolar current, waters are getting more saline as a result of evaporation. Our results show that it is not only the heat and freshwater fluxes through the sea surface that control the heat and salt changes of the upper limb of the overturning circulation in the Southern Hemisphere. In fact, internal mixing accounts for 25% of the heat change, and 22% of the salinity change.
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| 7. |
- Berglund, Sara, 1990-
(författare)
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Tracing pathways in the ocean circulation : A temperature and salinity perspective
- 2021
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The ocean circulation plays an essential role in our climate system. It redistributes heat, salt, carbon and other tracers across the globe, making the climate of Earth more moderate. This thesis targets density differences that are driving the ocean circulation. These differences are caused by changes in temperature and salinity. The analysis is based on the usage of Lagrangian trajectories simulated with velocity fields from an Earth System Model. The Lagrangian approach opens up for the possibility to follow specific water paths and water masses. The results herein provide a new insight to specific circulation patterns in the ocean, and which regions that play an important role in controlling temperature and salinity changes.In the first two articles, the Lagrangian divergence is introduced. It shows the geographical distribution of heat and salt changes of a simulated water mass. Using this, we are able to show that the northward flowing water in the Atlantic Ocean cools and freshens in the North Atlantic Subtropical Gyre, the Gulf Stream and the North Atlantic Current. Similarly, we show that the water flowing from the Drake Passage, following the Antarctic Circumpolar Current (ACC) and moving northwards into the Atlantic, Pacific and Indian oceans, transforms from cold and fresh to warm and saline. This warming and salinification are a result of, not only air-sea fluxes, but also interior mixing.In the third study, we show that 70% of the water flowing northwards as part of the Atlantic Meridional Overturning Circulation circuits the North Atlantic Subtropical Gyre at least once before it continues northwards. In the gyre, the water spirals downwards as it gets denser, due to a combination of air-sea fluxes and interior mixing. These results bring a new perspective on the Subtropical Gyre's role to the circulation patterns of the Atlantic Meridional Overturning Circulation.In the last part of this thesis, the circulation in the North Atlantic Ocean is traced into four different pathways. The pathways are visualised geographically together with their change in temperature, salinity and density. With this, we are able to show that the northward flowing water in the Atlantic Ocean exchanges heat and salt with the colder and fresher waters circulating the Subpolar Gyre.
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| 9. |
- Causevic, Sara, et al.
(författare)
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Prevalence and risk factors for transactional sex among Swedish-born and foreign-born MSM in Sweden
- 2022
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Ingår i: BMC Public Health. - : BioMed Central (BMC). - 1471-2458. ; 22
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Tidskriftsartikel (refereegranskat)abstract
- Background: Little is known about transactional sex (TS) (selling and buying sex) among men who have sex with men (MSM) in Sweden, especially among foreign-born MSM. This study aims to assess the prevalence and risk factors of TS (ever and in the previous five years) among MSM living in Sweden and to determine if there is a difference between Swedish-born MSM and foreign-born MSM.Methods: Swedish data from a multicountry online banner survey (EMIS-2017) was used (n = 4443). Multivariable regression analysis was applied to analyse the data.Results: The prevalence of ever-selling sex among all MSM participants was 13.2% and 5.9% in the previous five years. Selling sex ever and in the previous five years was higher among foreign-born MSM (16% and 8.4%, respectively) than Swedish-born MSM (12.7% and 5.4%, respectively). Among all participants, younger age (aOR:3.19, 95% CI:1.57-6.45) and really struggling to live on current income (aOR:3.37, 95% CI:2.29-4.96) increased the odds of selling sex. Being foreign-born MSM (aOR:1.33, 95% CI:1.02-1.73) and having had sex with a woman in the previous 12 months increased the odds of selling sex (aOR:1.44, 95% CI:1.00-2.07). The prevalence of ever buying sex among MSM participants in Sweden was 10.8% and 6.7% in the previous five years, with the same trend among foreign-born MSM (11.6% and 6.9%, respectively) and Swedish-born MSM (10.7% and 6.6%, respectively). Higher education and not having a current partner increased the odds of buying sex. Younger age was protective for buying sex (aOR:0.05, 95% CI:0.02-0.14). Among the foreign-born MSM, the length of stay in Sweden decreased the odds of buying sex (aOR: 0.98, 95% CI: 0.96-0.99).Conclusions: The comparatively high prevalence of TS among MSM participants in Sweden, where buying sex is illegal, with a higher prevalence among foreign-born MSM participants, calls for sexual and reproductive health and rights interventions in this population. Increased attention, including HIV prevention programming and education, should be aimed at younger MSM, MSM struggling with their current income, and foreign-born MSM, as they are more likely to report selling sex.
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| 10. |
- Erickson, A, et al.
(författare)
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Spatially resolved clonal copy number alterations in benign and malignant tissue
- 2022
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 608:7922, s. 360-
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Tidskriftsartikel (refereegranskat)abstract
- Defining the transition from benign to malignant tissue is fundamental to improving early diagnosis of cancer1. Here we use a systematic approach to study spatial genome integrity in situ and describe previously unidentified clonal relationships. We used spatially resolved transcriptomics2 to infer spatial copy number variations in >120,000 regions across multiple organs, in benign and malignant tissues. We demonstrate that genome-wide copy number variation reveals distinct clonal patterns within tumours and in nearby benign tissue using an organ-wide approach focused on the prostate. Our results suggest a model for how genomic instability arises in histologically benign tissue that may represent early events in cancer evolution. We highlight the power of capturing the molecular and spatial continuums in a tissue context and challenge the rationale for treatment paradigms, including focal therapy.
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