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Validation of F-18-...
Validation of F-18-FDG PET/MRI and diffusion-weighted MRI for estimating the extent of peritoneal carcinomatosis in ovarian and endometrial cancer : a pilot study
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- Jonsdottir, Björg (författare)
- Uppsala universitet,Reproduktiv hälsa
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- Ripoll, Montserrat Alemany (författare)
- Uppsala universitet,Radiologi
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- Bergman, Antonina, 1956- (författare)
- Uppsala universitet,Radiologi
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- Silins, Ilvars (författare)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa
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- Sundström Poromaa, Inger, 1964- (författare)
- Uppsala universitet,Reproduktiv hälsa
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- Ahlström, Håkan, 1953- (författare)
- Uppsala universitet,Radiologi,Medical AB, Antaros, Uppsala, Sweden.
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- Stålberg, Karin (författare)
- Uppsala universitet,Reproduktiv hälsa
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(creator_code:org_t)
- 2021-04-13
- 2021
- Engelska.
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Ingår i: Cancer Imaging. - : BioMed Central (BMC). - 1740-5025 .- 1470-7330. ; 21
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://cancerimagin...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: The extent of peritoneal carcinomatosis is difficult to estimate preoperatively, but a valid measure would be important in identifying operable patients. The present study set out to validate the usefulness of integrated F-18-FDG PET/MRI, in comparison with diffusion-weighted MRI (DW-MRI), for estimation of the extent of peritoneal carcinomatosis in patients with gynaecological cancer.Methods: Whole-body PET/MRI was performed on 34 patients with presumed carcinomatosis of gynaecological origin, all scheduled for surgery. Two radiologists evaluated the peritoneal cancer index (PCI) on PET/MRI and DW-MRI scans in consensus. The surgeon estimated PCI intraoperatively, which was used as the gold standard.Results: Median total PCI for PET/MRI (21.5) was closer to surgical PCI (24.5) (p = 0.6), than DW-MRI (median PCI 20.0, p = 0.007). However, both methods were highly correlated with the surgical PCI (PET/MRI: beta = 0.94 p < 0.01, DW-MRI: beta = 0.86, p < 0.01). PET/MRI was more accurate (p = 0.3) than DW-MRI (p = 0.001) when evaluating patients at primary diagnosis but no difference was noted in patients treated with chemotherapy. PET/MRI was superior in evaluating high tumour burden in inoperable patients. In the small bowel regions, there was a tendency of higher sensitivity but lower specificity in PET/MRI compared to DW-MRI.Conclusions: Our results suggest that FDG PET/MRI is superior to DW-MRI in estimating total spread of carcinomatosis in gynaecological cancer. Further, the greatest advantage of PET/MRI seems to be in patients at primary diagnosis and with high tumour burden, which suggest that it could be a useful tool when deciding about operability in gynaecological cancer.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Nyckelord
- PET
- MRI
- DW-MRI
- Ovarian cancer
- Peritoneal cancer index (PCI)
- Carcinomatosis
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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