Sökning: WFRF:(Berndt A)
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Effect of highly po...
Effect of highly potent antipseudomonal beta-lactam agents alone and in combination with aminoglycosides against Pseudomonas aeruginosa
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Lerner, S A (författare)
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Dudek, E J (författare)
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Boisvert, W E (författare)
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visa fler...
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Berndt, Kurt D (författare)
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visa färre...
- 1984
- 1984
- Engelska.
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Ingår i: Reviews Of Infectious Diseases. - 0162-0886. ; 6:Supplement 3, s. S678-88
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- The activities of ticarcillin, cefsulodin, ceftazidime, aztreonam, and imipenem, formerly known as N-formimidoyl thienamycin, were evaluated alone and in combination with aminoglycosides against 56 clinical isolates of Pseudomonas aeruginosa, which were characterized by aminoglycoside susceptibility and content of aminoglycoside-modifying enzymatic activities. All beta-lactam agents were highly active against aminoglycoside-susceptible isolates, and with few exceptions the aminoglycoside-resistant isolates were susceptible to all of the beta-lactam agents except ticarcillin. Combinations of the beta-lactam agents with aminoglycosides frequently acted synergistically, but the effect of different beta-lactam agents in combination with an aminoglycoside against individual strains was unpredictable. The presence or absence of an aminoglycoside-modifying enzymatic activity had no observed effect on synergism with tobramycin. Killing-curve experiments with strains in the presence of concentrations of a beta-lactam and an aminoglycoside that were not bactericidal alone (one-fourth the minimal bactericidal concentration) showed synergistic bactericidal action against four strains that were tested. The results demonstrate the great activity of these newer antipseudomonal beta-lactam agents and their potential for synergism with aminoglycosides.
Ämnesord
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
Nyckelord
- Aminoglycosides/pharmacology
- Anti-Bacterial Agents/*pharmacology
- Aztreonam/pharmacology
- Cefsulodin/pharmacology
- Ceftazidime/pharmacology
- Comparative Study
- Drug Synergism
- Humans
- Imipenem
- Microbial Sensitivity Tests
- Non-U.S. Gov't
- Penicillin Resistance
- Pseudomonas aeruginosa/*drug effects
- Research Support
- Thienamycins/pharmacology
- Ticarcillin/pharmacology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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