| 1. |
- Berntsson Svensson, Richard, et al.
(författare)
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Prioritization of quality requirements : State of practice in eleven companies
- 2011
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Ingår i: 2011 IEEE 19th International Requirements Engineering Conference, RE 2011; Trento; 29 August 2011 through 2 September 2011. - Trento : IEEE. - 9781457709234 ; , s. 69-78, s. 69-78
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Konferensbidrag (refereegranskat)abstract
- Requirements prioritization is recognized as an important but challenging activity in software product development. For a product to be successful, it is crucial to find the right balance among competing quality requirements. Although literature offers many methods for requirements prioritization, the research on prioritization of quality requirements is limited. This study identifies how quality requirements are prioritized in practice at 11 successful companies developing software intensive systems. We found that ad-hoc prioritization and priority grouping of requirements are the dominant methods for prioritizing quality requirements. The results also show that it is common to use customer input as criteria for prioritization but absence of any criteria was also common. The results suggests that quality requirements by default have a lower priority than functional requirements, and that they only get attention in the prioritizing process if decision-makers are dedicated to invest specific time and resources on QR prioritization. The results of this study may help future research on quality requirements to focus investigations on industry-relevant issues.
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| 2. |
- Berntsson Svensson, Richard, et al.
(författare)
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Quality Requirements in Industrial Practice – An Extended Interview Study at Eleven Companies
- 2012
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Ingår i: IEEE Transactions on Software Engineering. - : IEEE. - 0098-5589 .- 1939-3520. ; 38:4, s. 923-935
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Tidskriftsartikel (refereegranskat)abstract
- In order to create a successful software product and assure its quality, it is not enough to fulfill the functional requirements, it is also crucial to find the right balance among competing quality requirements (QR). An extended, previosluy piloted, interview study was performed to identify specific challenges associated with the selection, trade-off, and management of QR in industrial practice. Data was collected through semi-structured interviews with eleven product managers and eleven project leaders from eleven software companies. The contribution of this study is fourfold: First, it compares how QR are handled in two cases, companies working in business-to-business markets, and companies that are working in business-to-consumer markets. These two are also compared in terms of impact on the handling of QRs. Second, it compares the perceptions and priorities of QR by product and project management respectively. Third, it includes an examination of the interdependencies among quality requirements perceived as most important by the practitioners. Fourth, it characterizes the selection and management of QR in down-stream development activities.
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| 3. |
- Berntsson Svensson, Richard, 1978, et al.
(författare)
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Quality Requirements in Industrial Practice - An Extended Interview Study at Eleven Companies
- 2011
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Ingår i: IEEE Transactions on Software Engineering. - 0098-5589 .- 1939-3520.
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Tidskriftsartikel (refereegranskat)abstract
- In order to create a successful software product and assure its quality, it is not enough to fulfill the functional requirements, it is also crucial to find the right balance among competing quality requirements (QR). An extended, previously piloted, interview study was performed to identify specific challenges associated with the selection, trade-off, and management of QR in industrial practice. Data was collected through semi-structured interviews with eleven product managers and eleven project leaders from eleven software companies. The contribution of this study is fourfold: First, it compares how QR are handled in two cases, companies working in business-to-business markets, and companies that are working in business-to-consumer markets. These two are also compared in terms of impact on the handling of QRs. Second, it compares the perceptions and priorities of QR by product and project management respectively. Third, it includes an examination of the interdependencies among quality requirements perceived as most important by the practitioners. Fourth, it characterizes the selection and management of QR in down-stream development activities.
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| 4. |
- Gad, Helge, et al.
(författare)
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MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool
- 2014
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Ingår i: Nature. - : Nature Publishing Group. - 0028-0836 .- 1476-4687. ; 508:7495, s. 215-221
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Tidskriftsartikel (refereegranskat)abstract
- Cancers have dysfunctional redox regulation resulting in reactive oxygen species production, damaging both DNA and free dNTPs. The MTH1 protein sanitizes oxidized dNTP pools to prevent incorporation of damaged bases during DNA replication. Although MTH1 is non-essential in normal cells, we show that cancer cells require MTH1 activity to avoid incorporation of oxidized dNTPs, resulting in DNA damage and cell death. We validate MTH1 as an anticancer target in vivo and describe small molecules TH287 and TH588 as first-in-class nudix hydrolase family inhibitors that potently and selectively engage and inhibit the MTH1 protein in cells. Protein co-crystal structures demonstrate that the inhibitors bindin the active site of MTH1. The inhibitors cause incorporation of oxidized dNTPs in cancer cells, leading to DNA damage, cytotoxicity and therapeutic responses in patient-derived mouse xenografts. This study exemplifies the non-oncogene addiction concept for anticancer treatment and validates MTH1 as being cancer phenotypic lethal.
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| 5. |
- Berntsson, Ronnie P. -A., et al.
(författare)
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Structural insight into DNA binding and oligomerization of the multifunctional Cox protein of bacteriophage P2
- 2014
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Ingår i: Nucleic Acids Research. - : Oxford University Press (OUP). - 0305-1048 .- 1362-4962. ; 42:4, s. 2725-2735
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Tidskriftsartikel (refereegranskat)abstract
- The Cox protein from bacteriophage P2 is a small multifunctional DNA-binding protein. It is involved in site-specific recombination leading to P2 prophage excision and functions as a transcriptional repressor of the P2 Pc promoter. Furthermore, it transcriptionally activates the unrelated, defective prophage P4 that depends on phage P2 late gene products for lytic growth. In this article, we have investigated the structural determinants to understand how P2 Cox performs these different functions. We have solved the structure of P2 Cox to 2.4 angstrom resolution. Interestingly, P2 Cox crystallized in a continuous oligomeric spiral with its DNA-binding helix and wing positioned outwards. The extended C-terminal part of P2 Cox is largely responsible for the oligomerization in the structure. The spacing between the repeating DNA-binding elements along the helical P2 Cox filament is consistent with DNA binding along the filament. Functional analyses of alanine mutants in P2 Cox argue for the importance of key residues for protein function. We here present the first structure from the Cox protein family and, together with previous biochemical observations, propose that P2 Cox achieves its various functions by specific binding of DNA while wrapping the DNA around its helical oligomer.
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| 6. |
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| 7. |
- Berntsson Svensson, Richard, et al.
(författare)
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An investigation of how quality requirements are specified in industrial practice
- 2013
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Ingår i: Information and Software Technology. - : Elsevier BV. - 0950-5849 .- 1873-6025. ; 55:7, s. 1224-1236
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Tidskriftsartikel (refereegranskat)abstract
- Context: This paper analyses a sub-contractor specification in the mobile handset domain. Objective: The objective is to understand how quality requirements are specified and which types of requirements exist in a requirements specification from industry. Method: The case study is performed in the mobile handset domain, where a requirements specification was analyzed by categorizing and characterizing the pertaining requirements. Results: The requirements specification is written in structured natural language with unique identifiers for the requirements. Of the 2178 requirements, 827 (38%) are quality requirements. Of the quality requirements, 56% are quantified, i.e., having a direct metric in the requirement. The variation across the different sub-domains within the requirements specification is large. Conclusion: The findings from this study suggest that methods for quality requirements need to encompass many aspects to comprehensively support working with quality requirements. Solely focusing on, for example, quantification of quality requirements might overlook important requirements since there are many quality requirements in the studied specification where quantification is not appropriate. (C) 2013 Elsevier B.V. All rights reserved.
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| 8. |
- Berntsson Svensson, Richard, et al.
(författare)
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Cost and benefit analysis of quality requirements in competitive software product management: a case study on the QUPER model
- 2010
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Ingår i: 2010 Fourth International Workshop on Software Product Management. - 9781424487646
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Konferensbidrag (refereegranskat)abstract
- In market-driven product development, it is important that the software product is released to the market at the right time, and offers higher quality than the competitors. In release planning, the allocation of development effort in investments into product enhancements, functions are competing with quality requirements for limited resources. In addition, it is important to find the right balance between competing quality requirements. In this paper, we present an industrial evaluation of the benefit and cost views in the QUality PERformance (QUPER) model. The results indicate that the model is relevant in the release planning process, and that the combination of the benefit and cost views provides a clear picture of the current market situation.
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| 9. |
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| 10. |
- Berntsson Svensson, Richard, et al.
(författare)
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Setting quality targets for coming releases with QUPER - an industrial case study
- 2012
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Ingår i: Requirements Engineering. - : Springer Science and Business Media LLC. - 0947-3602 .- 1432-010X. ; 17:4, s. 283-298
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Tidskriftsartikel (refereegranskat)abstract
- Quality requirements play a critical role in driving architectural design and are an important issue in software development. Therefore, quality requirements need to be considered, specified, and quantified early during system analysis and not later in the development phase in an ad-hoc fashion. This paper presents the quality performance model that estimates quality targets in relation to market expectations as a basis for the architecting of quality requirements. The purpose of the model is to provide concepts for qualitative reasoning of quality levels in the decision-making of setting actual targets of quality requirements for coming releases of the product. The quality performance model is evaluated at one case company, using a market-driven development approach, in the electronic payment-processing domain. The results show that the model is useful for supporting early decisionmaking in, e.g., release planning of quality requirements
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