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Sökning: WFRF:(Bhardwaj P.) > (2002-2004) > Activation of HIV-1...

Activation of HIV-1 specific CD4 and CD8 T cells by human dendritic cells : Roles for cross-presentation and non-infectious HIV-1 virus

Larsson, M. (författare)
Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, NY, United States
Fonteneau, J.-F. (författare)
Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, NY, United States
Lirvall, M. (författare)
Linköpings universitet,Cellbiologi,Hälsouniversitetet
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Haslett, P. (författare)
Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, NY, United States
Lifson, J.D. (författare)
Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, NY, United States, Retroviral Pathogenesis Laboratory, AIDS Vaccine Program, National Cancer Institute, Fredrick, MD, United States
Bhardwaj, N. (författare)
Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, NY, United States
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 (creator_code:org_t)
Ovid Technologies (Wolters Kluwer Health), 2002
2002
Engelska.
Ingår i: AIDS. - : Ovid Technologies (Wolters Kluwer Health). - 0269-9370 .- 1473-5571. ; 16:10, s. 1319-1329
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Background: The CD4 T cells in mucosal subepithelia are the first cells to become infected during sexual transmission of HIV-1. Dendritic cells (DC) are located in the same area and are known to play a central role in antiviral immune responses. However, extensive viral replication, syncytia formation and cell death follows the interaction between T cells and DC previously exposed to HIV-1. Despite this, anti-HIV responses are generated that control viremia following acute infection.Objective: The anti-HIV-1 cellular immune responses observed may be activated by sources other than productively infected DC. HIV-1 induces apoptosis both in cells it infects and in bystander cells. Furthermore, retroviral replication typically generates a predominance of defective particles. We tested whether DC exposed to antigen from either of these sources could elicit anti-HIV specific immune responses.Design and methods: Apoptotic or necrotic monocytes infected with vaccinia virus vectors encoding HIV antigens, a cell line with integrated HIV-1 and apoptotic CD4 T cells pulsed with non-infectious or infectious HIV-1 virus were used as sources of antigens to assess cross presentation by DC. Furthermore, direct DC presentation of antigen from non-infectious and infectious HIV-1 was examined.Results: We find that dead cells expressing HIV-1 antigens as well as non-infectious HIV-1 particles can be acquired and processed by DC, leading to the activation, differentiation and expansion of viral antigen-specific CD4 and CD8 T cells from seropositive individuals.Conclusions: These sources of antigens may be critical for the generation and maintenance of anti-HIV-1 immunity by DC.

Nyckelord

Antigen presentation
Apoptosis
CD4 T cells
CD8 T cells
Dendritic cells
HIV-1
Immune response
NATURAL SCIENCES
NATURVETENSKAP

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