| 1. |
- Bahls, M., et al.
(författare)
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Progression of conventional cardiovascular risk factors and vascular disease risk in individuals: insights from the PROG-IMT consortium
- 2020
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Ingår i: European Journal of Preventive Cardiology. - : Oxford University Press (OUP). - 2047-4873 .- 2047-4881. ; 27:3
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Tidskriftsartikel (refereegranskat)abstract
- Aims: Averaged measurements, but not the progression based on multiple assessments of carotid intima-media thickness, (cIMT) are predictive of cardiovascular disease (CVD) events in individuals. Whether this is true for conventional risk factors is unclear. Methods and results: An individual participant meta-analysis was used to associate the annualised progression of systolic blood pressure, total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol with future cardiovascular disease risk in 13 prospective cohort studies of the PROG-IMT collaboration (n = 34,072). Follow-up data included information on a combined cardiovascular disease endpoint of myocardial infarction, stroke, or vascular death. In secondary analyses, annualised progression was replaced with average. Log hazard ratios per standard deviation difference were pooled across studies by a random effects meta-analysis. In primary analysis, the annualised progression of total cholesterol was marginally related to a higher cardiovascular disease risk (hazard ratio (HR) 1.04, 95% confidence interval (CI) 1.00 to 1.07). The annualised progression of systolic blood pressure, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol was not associated with future cardiovascular disease risk. In secondary analysis, average systolic blood pressure (HR 1.20 95% CI 1.11 to 1.29) and low-density lipoprotein cholesterol (HR 1.09, 95% CI 1.02 to 1.16) were related to a greater, while high-density lipoprotein cholesterol (HR 0.92, 95% CI 0.88 to 0.97) was related to a lower risk of future cardiovascular disease events. Conclusion: Averaged measurements of systolic blood pressure, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol displayed significant linear relationships with the risk of future cardiovascular disease events. However, there was no clear association between the annualised progression of these conventional risk factors in individuals with the risk of future clinical endpoints. © The European Society of Cardiology 2019.
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| 2. |
- Raack, J., et al.
(författare)
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Present-day gully activity in Sisyphi Cavi, Mars - Flow-like features and block movements
- 2020
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Ingår i: Icarus. - : Elsevier BV. - 0019-1035. ; 350
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Tidskriftsartikel (refereegranskat)abstract
- The continuously increasing number of multi-temporal high-resolution images from the surface of Mars offers the possibility for detailed studies of present-day surface activity. In this study we investigated all gullies in the Sisyphi Cavi region (355 degrees E, 71 degrees S) of the south polar region of Mars. This region is influenced by the seasonal deposition of a decimeters-thick translucent slab ice in late autumn/winter and its subsequent sublimation in spring. We mapped all gullies (n = 17.760) and measured their orientations. We also identified gullies with contemporary activity (n = 35) using multi-temporal HiRISE images for martian years (MY) 28 to 34. We observed two different kinds of activity: (1) dark flow-like features, and (2) movement of blocks. For both, sediment was transported from the source region (alcove and/or flanks of channels) down the gully. Using image data from HRSC, CTX, and HiRISE, we monitored the general defrosting of the study region. We also analyzed the maximum daytime surface temperatures of the complete study region based on TES data from MYs 24 to 26. To identify the origin and triggering mechanism of the observed activity, we used: (1) detailed topographic investigations (e.g., slope angles) of two extensively gullied slopes based on two HiRISE-DTMs, (2) identification of small scale displacements with Digital Image Correlation (DIC), and (3) orientation measurements of active gullies and comparison to non-active gullies. We found that for the active gullies studied, activity happens at the end of spring between L-S similar to 225 degrees and similar to 250 degrees. This is consistent with the timing of final stages of defrosting in the region. At this time, some surfaces are already defrosted while others still host the seasonal slab ice cover. For the surfaces with slab ice, dark defrosting spots (and flows, if the surface is inclined) are observed on dark dunes as well as on gully aprons and in gully channels. These spots form when, triggered by basal sublimation generated overpressure, sediment entrained in CO2-gas is transported through cracks within the ice and redeposited onto the frosted surface. We compared and linked both morphologic features (dark dune spots and dark flow-like features) and concluded that these features have comparable or even the same triggering mechanisms. Based on this extensive study, the most plausible mechanism for ongoing gully activity can be divided into two steps: 1) accumulation of material within gully channels via small dry flows on top of the slab ice (comparable to dark dune spots/flows), 2) when a critical mass is reached, the sediment flows down the still frosted gully on top of the sublimating ice or as a mixture of dry material and ice in a catastrophic flow. The triggering factor for the movement of blocks remains unclear, as their timing could not be constrained with the available data. We identified headwall erosion in one gully in the study region, whereas a discrete source could not be identified for the other sites, suggesting multiple failure mechanisms could be active in such gullies. Finally, through volume balance calculations we show that active gullies in Sisyphi Cavi could have been formed within decades to several tens of thousands of MY, but gully-morphology indicates a much-longer period for formation of the entire gully-landform.
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| 3. |
- Datta-Chaudhuri, Timir, et al.
(författare)
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The Fourth Bioelectronic Medicine Summit "Technology Targeting Molecular Mechanisms" : current progress, challenges, and charting the future
- 2021
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Ingår i: Bioelectronic medicine. - : BioMed Central. - 2332-8886. ; 7:1
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- There is a broad and growing interest in Bioelectronic Medicine, a dynamic field that continues to generate new approaches in disease treatment. The fourth bioelectronic medicine summit "Technology targeting molecular mechanisms" took place on September 23 and 24, 2020. This virtual meeting was hosted by the Feinstein Institutes for Medical Research, Northwell Health. The summit called international attention to Bioelectronic Medicine as a platform for new developments in science, technology, and healthcare. The meeting was an arena for exchanging new ideas and seeding potential collaborations involving teams in academia and industry. The summit provided a forum for leaders in the field to discuss current progress, challenges, and future developments in Bioelectronic Medicine. The main topics discussed at the summit are outlined here.
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