| 1. |
- Birgegård, Gunnar, 1944-, et al.
(författare)
-
Serum ferritin during infection : A longitudinal study
- 1978
-
Ingår i: Scandinavian journal of haematology. - 0036-553X. ; 21:4, s. 333-340
-
Tidskriftsartikel (refereegranskat)abstract
- Serum ferritin, transferrin, iron and haptoglobin have been investigated in a longitudinal study in 18 patients hospitalized for various acute infections. Within a couple of days after the onset of an infection, a rise in serum ferritin was seen, the magnitude of which was not dependent on the type of infection (bacterial or viral). The serum ferritin level remained elevated for several weeks in some patients, and 7 out of the 18 patients still had abnormally high values 5 weeks after the onset of illness. The mean curves for serum ferritin and the acute phase reactant haptoglobin were parallel. Possible mechanisms causing the elevation in serum ferritin are discussed.
|
|
| 2. |
- Birgegård, Gunnar, et al.
(författare)
-
Serum ferritin and erythrocyte 2,3-DPG during quantitated phlebotomy and iron treatment
- 1977
-
Ingår i: Scandinavian journal of haematology. - 0036-553X. ; 19:4, s. 327-333
-
Tidskriftsartikel (refereegranskat)abstract
- Serum ferritin and erythrocyte 2,3-DPG levels were followed in 3 healthy males who were phlebotomized to iron depletion and a moderate anaemia. In 2 of the subjects, the expected rise in DPG levels was seen but not in the third, in spite of a Hb concentration of 95 g/1. Serum ferritin levels were found to reflect changes in iron stores, and subnormal serum ferritin indicated depleted iron stores. However, there was no correlation between pre-phlebotomy ferritin levels and calculated iron stores. The conclusion is that no fixed ratio can be established between serum ferritin and iron stores. A single ferritin value within the normal range does not tell how large iron stores a person has. Changes in an individual's iron stores can, however, be detected by repeated ferritin estimations.
|
|
| 3. |
- Birgegård, Gunnar, 1944-, et al.
(författare)
-
Serum ferritin during infection : A longitudinal study in renal transplant patients
- 1979
-
Ingår i: Acta medica Scandinavica. - 0001-6101. ; 205:7, s. 641-645
-
Tidskriftsartikel (refereegranskat)abstract
- In order to follow the dynamics in the reaction of iron kinetic variables to acute infection, 8 renal transplantation patients were followed with test samples every second or third day for about two months. It was found that they just as previously shown in otherwise healthy subjects, responded to acute infection with a rise in serum ferritin levels, sometimes to very high values. In most cases the ferritin elevation started within two days after the onset of fever. The peak was reached within a week, except when very high values were obtained. The fall in serum ferritin after recovery from infection was much faster than in previously investigated groups of patients: the plasma half disappearance time for ferritin in one case was but 1.5 days. Transferrin did not change in response to infection. The expected fall in serum iron during infection was often absent and sometimes obscured by unexpected, sharp peaks in serum iron, which bore a temporal relationship to episodes of transplant rejection in 7 of 12 cases.
|
|
| 4. |
- Birgegård, Gunnar, et al.
(författare)
-
Serum ferritin levels in male blood donors : relation to number of phlebotomies and iron supplementation
- 1978
-
Ingår i: Vox Sanguinis. - 0042-9007 .- 1423-0410. ; 34:2, s. 65-70
-
Tidskriftsartikel (refereegranskat)abstract
- Serum ferritin estimation has been shown to be a reliable test to reveal iron deficiency. Such estimations have been made in groups of male blood donors with a varying number of previous phlebotomies and a mean interval between donations of 9.9 +/- 1.7 SD weeks. It was found that the mean ferritin level was significantly (p less than 0.001) lower in the blood donors than in nondonors. After 6-8 phlebotomies it was about 40% lower. Subnormal ferritin values were found in 10% of the donors, almost exclusively among those who had taken less than 1,000 mg of iron supplementation since the last donation. It is concluded that with a donation interval of about 10 weeks, there is a considerable risk for iron deficiency after about 6 donations. This risk is far less if more than 1,000 mg of iron supplementation is taken between phlebotomies. A role for serum ferritin estimation in monitoring donation intervals and/or iron therapy is suggested.
|
|
| 5. |
- Simonsson, Bengt, et al.
(författare)
-
Ferastral treatment of three healthy phlebotomized males
- 1977
-
Ingår i: Scandinavian journal of haematology. Supplementum. - 0080-6722. ; 32, s. 239-244
-
Tidskriftsartikel (refereegranskat)abstract
- Iron deficiency anaemia was produced by repeated phlebotomies in three healthy males. The storage iron was estimated as 666, 522 and 750 mg. After treatment with 1 000 mg of Ferastral the blood haemoglobin concentration rose at an average daily rate of 0.1 g/100 ml/day. Ninety per cent of the injected iron could be accounted for, and the utilization was estimated to about 70-80%. Side effects comprised pain and discolouration at the injection site.
|
|
