| 1. |
- Bishop, D. Timothy, et al.
(författare)
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Genome-wide association study identifies three loci associated with melanoma risk
- 2009
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 41:8, s. 920-925
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Tidskriftsartikel (refereegranskat)abstract
- We report a genome-wide association study of melanoma conducted by the GenoMEL consortium based on 317K tagging SNPs for 1,650 selected cases and 4,336 controls, with replication in an additional two cohorts (1,149 selected cases and 964 controls from GenoMEL, and a population-based case-control study in Leeds of 1,163 cases and 903 controls). The genome-wide screen identified five loci with genotyped or imputed SNPs reaching P < 5 x 10(-7). Three of these loci were replicated: 16q24 encompassing MC1R (combined P = 2.54 x 10(-27) for rs258322), 11q14-q21 encompassing TYR (P = 2.41 x 10(-14) for rs1393350) and 9p21 adjacent to MTAP and flanking CDKN2A (P = 4.03 x 10(-7) for rs7023329). MC1R and TYR are associated with pigmentation, freckling and cutaneous sun sensitivity, well-recognized melanoma risk factors. Common variants within the 9p21 locus have not previously been associated with melanoma. Despite wide variation in allele frequency, these genetic variants show notable homogeneity of effect across populations of European ancestry living at different latitudes and show independent association to disease risk.
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| 2. |
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| 3. |
- Buffam, Ishi, et al.
(författare)
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Spatial heterogeneity of the spring flood acid pulse in a boreal stream network.
- 2008
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Ingår i: Science of the Total Environment. - : Elsevier BV. - 0048-9697 .- 1879-1026. ; 407:1, s. 708-22
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Tidskriftsartikel (refereegranskat)abstract
- Spatial and temporal patterns in streamwater acidity are ecologically important, but difficult to measure in parallel. Here we present the spatial distribution of streamwater chemistry relevant to acidity from 60 stream sites distributed throughout a 67 km(2) boreal catchment, sampled during a period of winter baseflow (high pH) and during a spring flood episode (low pH). Sites were grouped based on pH level and pH change from winter baseflow to spring flood. The site attributes of each pH group were then assessed in terms of both stream chemistry and subcatchment landscape characteristics. Winter baseflow pH was high throughout most of the stream network (median pH 6.4), but during the spring flood episode stream sites experienced declines in pH ranging from 0-1.6 pH units, resulting in pH ranging from 4.3-6.3. Spring flood pH was highest in larger, lower altitude catchments underlain by fine sorted sediments, and lowest in small, higher altitude catchments with a mixture of peat wetlands and forested till. Wetland-dominated headwater catchments had low but stable pH, while the spring flood pH drop was largest in a group of catchments of intermediate size which contained well-developed coniferous forest and a moderate proportion of peat wetlands. There was a trend with distance downstream of higher pH, acid neutralizing capacity (ANC) and base cation concentrations together with lower dissolved organic carbon (DOC, strongly negatively correlated with pH). This apparent scale-dependence of stream chemistry could be explained by a number of environmental factors which vary predictably with altitude, catchment area and distance downstream-most notably, a shift in surficial sediment type from unsorted till and peat wetlands to fine sorted sediments at lower altitudes in this catchment. As a result of the combination of spatial heterogeneity in landscape characteristics and scale-related processes, boreal catchments like this one can be expected to experience high spatial variability both in terms of chemistry at any given point in time, and in the change experienced during high discharge episodes. Although chemistry patterns showed associations with landscape characteristics, considerable additional variability remained, suggesting that the modeling of dynamic stream chemistry from map parameters will continue to present a challenge. (C) 2008 Elsevier B.V. All rights reserved.
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| 4. |
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| 5. |
- Grabs, Thomas, 1980-, et al.
(författare)
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Modeling spatial patterns of saturated areas: A comparison of the topographic wetness index and a dynamic distributed model
- 2009
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Ingår i: Journal of Hydrology. - : Elsevier BV. - 0022-1694 .- 1879-2707. ; 373:1-2, s. 15-23
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Tidskriftsartikel (refereegranskat)abstract
- Topography is often one of the major controls on the spatial pattern of saturated areas, which in turn is akey to understanding much of the variability in soils, hydrological processes, and stream water quality.The topographic wetness index (TWI) has become a widely used tool to describe wetness conditions atthe catchment scale. With this index, however, it is assumed that groundwater gradients always equalsurface gradients. To overcome this limitation, we suggest deriving wetness indices based on simulationsof distributed catchment models. We compared these new indices with the TWI and evaluated the differ-ent indices by their capacity to predict spatial patterns of saturated areas. Results showed that the model-derived wetness indices predicted the spatial distribution of wetlands significantly better than the TWI.These results encourage the use of a dynamic distributed hydrological model to derive wetness indexmaps for hydrological landscape analysis in catchments with topographically driven groundwater tables.
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| 6. |
- Köhler, S. J., et al.
(författare)
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Dynamics of stream water TOC concentrations in a boreal headwater catchment : Controlling factors and implications for climate scenarios
- 2009
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Ingår i: Journal of Hydrology. - : Elsevier BV. - 0022-1694 .- 1879-2707. ; 373:1-2, s. 44-56
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Tidskriftsartikel (refereegranskat)abstract
- Two different but complementary modelling approaches for reproducing the observed dynamics of total organic carbon (TOC) in a boreal stream are presented. One is based on a regression analysis, while the other is based on riparian soil conditions using a convolution of flow and concentration. Both approaches are relatively simple to establish and help to identify gaps in the process understanding of the TOC transport from soils to catchments runoff. The largest part of the temporal variation of stream TOC concentrations (4-46 mg L-1) in a forested headwater stream in the boreal zone in northern Sweden may be described using a four-parameter regression equation that has runoff and transformed air temperature as sole input variables. Runoff is assumed to be a proxy for soil wetness conditions and changing flow pathways which in turn caused most of the stream TOC variation. Temperature explained a significant part of the observed inter-annual variability. Long-term riparian hydrochemistry in soil solutions within 4 m of the stream also captures a surprisingly large part of the observed variation of stream TOC and highlights the importance of riparian soils. The riparian zone was used to reproduce stream TOC with the help of a convolution model based on flow and average riparian chemistry as input variables. There is a significant effect of wetting of the riparian soil that translates into a memory effect for subsequent episodes and thus contributes to controlling stream TOC concentrations. Situations with high flow introduce a large amount of variability into stream water TOC that may be related to memory effects, rapid groundwater fluctuations and other processes not identified so far. Two different climate scenarios for the region based on the IPCC scenarios were applied to the regression equation to test what effect the expected increase in precipitation and temperature and resulting changes in runoff would have on stream TOC concentrations assuming that the soil conditions remain unchanged. Both scenarios resulted in a mean increase of stream TOC concentrations of between 1.5 and 2.5 mg L-1 during the snow free season, which amounts to approximately 15% more TOC export compared to present conditions. Wetter and warmer conditions in the late autumn led to a difference of monthly average TOC of up to 5 mg L-1, suggesting that stream TOC may be particularly susceptible to climate variability during this season.
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| 7. |
- Laudon, Hjalmar, et al.
(författare)
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The Krycklan Catchment Study, Sweden: A field based experimental platform for linking small-scale process understanding to landscape patterns
- 2007
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- The Krycklan Catchment Study (KCS) (http://ccrew.sek.slu.se/krycklan), is a multiscale experimental catchment located in the boreal region of northern Sweden. The catchment is extensively instrumented for hydrological and biogeochemical research, including 15 permanent gauging stations, ranging from 3 ha to 6700 ha in size, intensively sampled and continuously monitored to quantify temporal and spatial variations in water chemistry and discharge. An additional 90 locations are sampled occasionally for water chemistry at different runoff stages. The multi-investigator KCS has been developed to provide a direct insight into the governing hydrological and biogeochemical processes at a range of catchment scales and consists at present of over 30 separate projects. Its location within an established Experimental Forest provides a comprehensive instrumental infrastructure, long-term climate monitoring facilities and a small research catchment where process-based hillslope, hydrological and biogeochemical research has been conducted for three decades. Recently two new major investments are being implemented. The first includes a Riparian Observatory with over 200 soil lysimeters in the riparian zone. The second investment is the use of laserscanning (LIDAR) which makes KCS one of the first large-scale research catchments where high-resolution elevation and ground cover data are available for hydrological and water quality modeling.
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| 8. |
- Seibert, Jan, et al.
(författare)
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Linking soil- and stream-water chemistry based on a Riparian Flow-Concentration Integration Model
- 2009
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Ingår i: Hydrology and earth system sciences. - : Copernicus Publications. - 1607-7938 .- 1027-5606. ; 13:12, s. 2287-2297
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Tidskriftsartikel (refereegranskat)abstract
- The riparian zone, the last few metres of soil through which water flows before entering a gaining stream, has been identified as a first order control on key aspects of stream water chemistry dynamics. We propose that the distribution of lateral flow of water across the vertical profile of soil water chemistry in the riparian zone provides a conceptual explanation of how this control functions in catchments where matrix flow predominates. This paper presents a mathematical implementation of this concept as well as the model assumptions. We also present an analytical solution, which provides a physical basis for the commonly used power-law flow-load equation. This approach quantifies the concept of riparian control on stream-water chemistry providing a basis for testing the concept of riparian control. By backward calculation of soil-water-chemistry profiles, and comparing those with observed profiles we demonstrate that the simple juxtaposition of the vertical profiles of water flux and soil water chemistry provides a plausible explanation for observed variations in stream water chemistry of several major stream components such as Total Organic Carbon (TOC), magnesium, calcium and chloride. The "static" implementation of the model structure presented here provides a basis for further development to account for seasonal influences and hydrological hysteresis in the representation of hyporheic, riparian, and hillslope processes.
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| 9. |
- Sörensen, Rasmus, et al.
(författare)
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Forest Harvest Increases Runoff Most during Low Flows in Two Boreal Streams
- 2009
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Ingår i: Ambio. - : Royal Swedish Academy of Sciences. - 0044-7447 .- 1654-7209. ; 38:7, s. 357-363
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- To understand how forest harvest influences the aquatic environment, it is essential to determine the changes in the flow regime. This paper presents changes in the hydrological regime during the first 2 y after harvest in two catchments of the Balsjo Catchment Study in Sweden. The changes were judged relative to a reference catchment, calibrated during an 18-mo pretreatment period starting in September 2004. From August 2006 through March 2008, there was an average of 35% more runoff from the harvested catchments relative to the reference. The flow increased most during the growing seasons and at base flows (< 1 mm d(-1); 58-99% increase), followed by dormant season and intermediate flows (30-43%). No significant changes were observed during the highest flows (over 5 mm d(-1)), except for the spring flood a few weeks after harvest, which was delayed and attenuated. Large relative changes in low flow may influence the ecosystem by altering the aquatic habitat
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| 10. |
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