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- Björklund, Erik, et al.
(författare)
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Admission Troponin T and measurement of ST-segment resolution at 60 min improve early risk stratification in ST-elevation myocardial infarction
- 2004
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Ingår i: Eur Heart J. - : Oxford University Press (OUP). - 0195-668X .- 1522-9645. ; 25:2, s. 113-20
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Tidskriftsartikel (refereegranskat)abstract
- AIMS: The prognostic value of admission troponin T (tnT) levels and the resolution of the ST-segment elevation in ST-elevation myocardial infarction (STEMI) is well established. However, the combination of these two early available markers for predicting risk has not been evaluated. METHODS AND RESULTS: We evaluated 516 patients with fibrinolytic treated STEMI from the ASSENT-2 and ASSENT-PLUS studies, which had both admission tnT and ST-monitoring available. We used a prospectively defined cut-off value of tnT of 0.1microg/l. For ST-segment resolution, a cut-off of 50% measured after 60min was used. Both a tnT >/=0.1microg/l (n=116) and ST-segment resolution <50% (n=301) were related to higher one-year mortality, 13% vs 4% (P<0.001) and 8.4% vs 2.8% (P=0.009), respectively. In a multivariate analysis ST-segment resolution was and tnT showed a strong trend to be independently related to mortality. The combination of both further improved risk stratification. The one-year mortality in the group with elevation of tnT and without ST-segment resolution compared to the group without tnT elevation and with ST-segment resolution was 18.2% vs 2.8% (P<0.001). CONCLUSIONS: Both tnT on admission and ST-segment resolution after 60min are strong predictors of one-year mortality. The combination of both gives additive early information about prognosis and further improves risk stratification.
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| 4. |
- Brundin, Patrik, et al.
(författare)
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Bilateral caudate and putamen grafts of embryonic mesencephalic tissue treated with lazaroids in Parkinson's disease
- 2000
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Ingår i: Brain. - 1460-2156. ; 123, s. 1380-1390
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Tidskriftsartikel (refereegranskat)abstract
- Five parkinsonian patients were transplanted bilaterally into the putamen and caudate nucleus with human embryonic mesencephalic tissue from between seven and nine donors. To increase graft survival, the lipid peroxidation inhibitor tirilazad mesylate was administered to the tissue before implantation and intravenously to the patients for 3 days thereafter. During the second postoperative year, the mean daily L-dopa dose was reduced by 54% and the UPDRS (Unified Parkinson's Disease Rating Scale) motor score in 'off' phase was reduced by a mean of 40%. At 10-23 months after grafting, PET showed a mean 61% increase of 6-L-[(18)F]fluorodopa uptake in the putamen, and 24% increase in the caudate nucleus, compared with preoperative values. No obvious differences in the pattern of motor recovery were observed between these and other previously studied cases with putamen grafts alone. The amount of mesencephalic tissue implanted in each putamen and caudate nucleus was 42 and 50% lower, respectively, compared with previously transplanted patients from our centre. Despite this reduction in grafted tissue, the magnitudes of symptomatic relief and graft survival were very similar. These findings suggest that tirilazad mesylate may improve survival of grafted dopamine neurons in patients, which is in agreement with observations in experimental animals.
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| 6. |
- Lindholm, Per, et al.
(författare)
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Characterization of wear on a cam follower system in a diesel engine
- 2003
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Ingår i: Wear 254. - : Elsevier. ; , s. 1199-1207
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Tidskriftsartikel (refereegranskat)abstract
- This paper presents an investigation of the running in of the most important contact surfaces of a modern diesel cam follower system. The test equipment used consists of a commercially available cylinder head with an overhead camshaft and valve train system for six cylinders. The load on the contacting surfaces is varied by controlling the fuel injector pumps. The running in is investigated by analysing the changes in topography of the roller, pin and rocker arm of the fuel injector arm. Seven test series were conducted for 1, 10 and 100 h with a variation of the load and speed between a high and low level. The test time was not long enough to be able to see any changes in the surface topography of the roller or pin surfaces. However the wear on the roller bearing surface and the rocker arm bearing surface was significant. Here the surface peak heights are worn off and the surfaces are smoothed out. The observed changes in surface topography are related to the current lubrication regime and the wear is discussed in terms of the λ -value.
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| 7. |
- Lindholm, Per, et al.
(författare)
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Contact conditions in a cam and roller contact
- 2001
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Ingår i: Proceedings of World Tribology Congress WT2001. - Wien : Österreichische Tribologishe Gesellshaft. - 390165707X
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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