1. |
|
|
2. |
|
|
3. |
|
|
4. |
- Litton, JE, et al.
(författare)
-
Data modeling and data communication in GenomEUtwin
- 2003
-
Ingår i: Twin research : the official journal of the International Society for Twin Studies. - : Cambridge University Press (CUP). - 1369-0523. ; 6:5, s. 383-390
-
Tidskriftsartikel (refereegranskat)
|
|
5. |
|
|
6. |
|
|
7. |
|
|
8. |
|
|
9. |
|
|
10. |
- Rosenblad, Carl, et al.
(författare)
-
In vivo protection of nigral dopamine neurons by lentiviral gene transfer of the novel GDNF-family member neublastin/artemin
- 2000
-
Ingår i: Molecular and Cellular Neuroscience. - : Elsevier BV. - 1044-7431. ; 15:2, s. 199-214
-
Tidskriftsartikel (refereegranskat)abstract
- The glial cell line-derived neurotrophic factor (GDNF)-family of neurotrophic factors consisted until recently of three members, GDNF, neurturin, and persephin. We describe here the cloning of a new GDNF-family member, neublastin (NBN), identical to artemin (ART), recently published (Baloh et al., 1998). Addition of NBN/ART to cultures of fetal mesencephalic dopamine (DA) neurons increased the number of surviving tyrosine hydroxylase (TH)-immunoreactive neurons by approximately 70%, similar to the maximal effect obtained with GDNF. To investigate the neuroprotective effects in vivo, lentiviral vectors carrying the cDNA for NBN/ART or GDNF were injected into the striatum and ventral midbrain. Three weeks after an intrastriatal 6-hydroxydopamine lesion only about 20% of the nigral DA neurons were left in the control group, while 80-90% of the DA neurons remained in the NBN/ART and GDNF treatment groups, and the striatal TH-immunoreactive innervation was partly spared. We conclude that NBN/ART, similarly to GDNF, is a potent neuroprotective factor for the nigrostriatal DA neurons in vivo.
|
|