| 1. |
- Vogel, Jacob W., et al.
(författare)
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Four distinct trajectories of tau deposition identified in Alzheimer’s disease
- 2021
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Ingår i: Nature Medicine. - : Springer Science and Business Media LLC. - 1078-8956 .- 1546-170X. ; 27:5, s. 871-881
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Tidskriftsartikel (refereegranskat)abstract
- Alzheimer’s disease (AD) is characterized by the spread of tau pathology throughout the cerebral cortex. This spreading pattern was thought to be fairly consistent across individuals, although recent work has demonstrated substantial variability in the population with AD. Using tau-positron emission tomography scans from 1,612 individuals, we identified 4 distinct spatiotemporal trajectories of tau pathology, ranging in prevalence from 18 to 33%. We replicated previously described limbic-predominant and medial temporal lobe-sparing patterns, while also discovering posterior and lateral temporal patterns resembling atypical clinical variants of AD. These ‘subtypes’ were stable during longitudinal follow-up and were replicated in a separate sample using a different radiotracer. The subtypes presented with distinct demographic and cognitive profiles and differing longitudinal outcomes. Additionally, network diffusion models implied that pathology originates and spreads through distinct corticolimbic networks in the different subtypes. Together, our results suggest that variation in tau pathology is common and systematic, perhaps warranting a re-examination of the notion of ‘typical AD’ and a revisiting of tau pathological staging. © 2021, The Author(s), under exclusive licence to Springer Nature America, Inc.
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| 2. |
- Koumpia, E., et al.
(författare)
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Optical and near-infrared observations of the Fried Egg Nebula: Multiple shell ejections on a 100 yr timescale from a massive yellow hypergiant
- 2020
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 635
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Tidskriftsartikel (refereegranskat)abstract
- Context. The fate of a massive star during the latest stages of its evolution is highly dependent on its mass-loss rate and geometry and therefore knowing the geometry of the circumstellar material close to the star and its surroundings is crucial. Aims. We aim to provide insight into the nature (i.e. geometry, rates) of mass-loss episodes, and in particular, the connection between the observed asymmetries due to the mass lost in a fast wind or during a previous, prodigious mass-losing phase. In this context, yellow hypergiants offer a good opportunity to study mass-loss events. Methods. We analysed a large set of optical and near-infrared data in spectroscopic and photometric, spectropolarimetric, and interferometric (GRAVITY/VLTI) modes, towards the yellow hypergiant IRAS 17163-3907. We used X-shooter optical observations to determine the spectral type of this yellow hypergiant and we present the first model-independent, reconstructed images of IRAS 17163-3907 at these wavelengths tracing milli-Arcsecond scales. Lastly, we applied a 2D radiative transfer model to fit the dereddened photometry and the radial profiles of published diffraction-limited VISIR images at 8.59 μm, 11.85 μm, and 12.81 μm simultaneously, adopting a revised distance determination using Gaia Data Release 2 measurements. Results. We constrain the spectral type of IRAS 17163-3907 to be slightly earlier than A6Ia (Teffâ ∼â 8500 K). The interferometric observables around the 2 μm window towards IRAS 17163-3907 show that the Brγ emission appears to be more extended and asymmetric than the Naâ » I and the continuum emission. Interestingly, the spectrum of IRAS 17163-3907 around 2 μm shows Mgâ » II emission that is not previously seen in other objects of its class. In addition, Brγ shows variability in a time interval of four months that is not seen towards Naâ » I. Lastly, in addition to the two known shells surrounding IRAS 17163-3907, we report on the existence of a third hot inner shell with a maximum dynamical age of only 30 yr. Conclusions. The 2 μm continuum originates directly from the star and not from hot dust surrounding the stellar object. The observed spectroscopic variability of Brγ could be a result of variability in the mass-loss rate. The interpretation of the presence of Naâ » I emission at closer distances to the star compared to Brγ has been a challenge in various studies. To address this, we examine several scenarios. We argue that the presence of a pseudo-photosphere, which was traditionally considered to be the prominent explanation, is not needed and that it is rather an optical depth effect. The three observed distinct mass-loss episodes are characterised by different mass-loss rates and can inform theories of mass-loss mechanisms, which is a topic still under debate both in theory and observations. We discuss these in the context of photospheric pulsations and wind bi-stability mechanisms.
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| 3. |
- Koumpia, Evgenia, et al.
(författare)
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Tracing a decade of activity towards a yellow hypergiant. The spectral and spatial morphology of IRC+10420 at au scales
- 2022
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Ingår i: Monthly Notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 515:2, s. 2766-2777
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Tidskriftsartikel (refereegranskat)abstract
- The fate of a massive star during the latest stages of its evolution is highly dependent on its mass-loss history and geometry, with the yellow hypergiants (YHGs) being key objects. We present near-IR interferometric observations of the famous YHG IRC+10420 and blue spectra taken between 1994 and 2019. Our 2.2-mu m GRAVITY/VLTI observations attain a spatial resolution of similar to 5 stellar radii and spatially resolve the hot emission in the K-band tracing the gas via Na i doublet emission and the Br gamma emission. Our geometric modelling reveals a compact neutral zone (Na i) which is slightly larger than the continuum but within an extended Br gamma emitting region. Our study confirms an hour-glass geometry of the wind, but we find no signature of a companion at 7-800 au separations at the contrast limit of our observations (3.7 mag at 3 sigma) to explain this geometry. We report an evolution of the ejecta over 7 yr, and constrain the opening angle of the hour-glass to be <10 degrees. Lastly, we present the first blue optical spectra of IRC+10420 since 1994. The multi-epoch data indicate that the spectral type, and thus temperature, of the object has essentially remained constant during the intervening years. Therefore, the observed increase in temperature of 2000 K in less than two decades prior to 1994 is now halted. This suggests that this YHG has 'hit' the White Wall in the HR-diagram preventing it from evolving blue-wards, and will likely undergo a major mass-loss event in the near future.
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| 4. |
- Muller, Sebastien, 1976, et al.
(författare)
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Detection of deuterated molecules, but not of lithium hydride, in the z=0.89 absorber toward PKS 1830-211
- 2020
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 637
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Tidskriftsartikel (refereegranskat)abstract
- Deuterium and lithium are light elements of high cosmological and astrophysical importance. In this work we report the first detection of deuterated molecules and a search for lithium hydride, (LiH)-Li-7, at redshift z=0.89 in the spiral galaxy intercepting the line of sight to the quasar PKS 1830-211. We used ALMA to observe several submillimeter lines of ND, NH2D, and HDO, and their related isotopomers NH2, NH3, and (H2O)-O-18 H 2 18 O , in absorption against the southwest image of the quasar, allowing us to derive XD/XH abundance ratios. The absorption spectra mainly consist of two distinct narrow velocity components for which we find remarkable differences. One velocity component shows XD/XH abundances that is about 10 times larger than the primordial elemental D/H ratio, and no variability of the absorption profile during the time span of our observations. In contrast, the other component shows a stronger deuterium fractionation. Compared to the first component, this second component has XD/XH abundances that are 100 times larger than the primordial D/H ratio, a deepening of the absorption by a factor of two within a few months, and a rich chemical composition, with relative enhancements of N2H+, CH3OH, SO2 and complex organic molecules. We therefore speculate that this component is associated with the analog of a Galactic dark cloud, while the first component is likely more diffuse. Our search for the (LiH)-Li-7 (1-0) line was unsuccessful and we derive an upper limit (LiH)-Li-7/H-2 = 4x10(-13) (3 sigma) in the z=0.89 absorber toward PKS 1830-211. Besides, with ALMA archival data, we could not confirm the previous tentative detections of this line in the z=0.68 absorber toward B 0218+357; we derive an upper limit (LiH)-Li-7/H-2 = 5x10(-11) (3 sigma), although this is less constraining than our limit toward PKS 1830-211. We conclude that, as in the Milky Way, only a tiny fraction of lithium nuclei are possibly bound in LiH in these absorbers at intermediate redshift.
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| 5. |
- Ramdas, S., et al.
(författare)
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A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids
- 2022
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Ingår i: American Journal of Human Genetics. - : Elsevier BV. - 0002-9297 .- 1537-6605. ; 109:8, s. 1366-1387
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Tidskriftsartikel (refereegranskat)abstract
- A major challenge of genome-wide association studies (GWASs) is to translate phenotypic associations into biological insights. Here, we integrate a large GWAS on blood lipids involving 1.6 million individuals from five ancestries with a wide array of functional genomic datasets to discover regulatory mechanisms underlying lipid associations. We first prioritize lipid-associated genes with expression quantitative trait locus (eQTL) colocalizations and then add chromatin interaction data to narrow the search for functional genes. Polygenic enrichment analysis across 697 annotations from a host of tissues and cell types confirms the central role of the liver in lipid levels and highlights the selective enrichment of adipose-specific chromatin marks in high-density lipoprotein cholesterol and triglycerides. Overlapping transcription factor (TF) binding sites with lipid-associated loci identifies TFs relevant in lipid biology. In addition, we present an integrative framework to prioritize causal variants at GWAS loci, producing a comprehensive list of candidate causal genes and variants with multiple layers of functional evidence. We highlight two of the prioritized genes, CREBRF and RRBP1, which show convergent evidence across functional datasets supporting their roles in lipid biology.
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