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Sökning: WFRF:(Blaha Ludek) > (2014) > Mixtures of chemica...

Mixtures of chemical pollutants at European legislation safety concentrations : how safe are they?

Carvalho, Raquel N. (författare)
Institute for Environment and Sustainability, European Commission-DG Joint Research Centre, Ispra, Italy
Arukwe, Augustine (författare)
Norwegian University of Science & Technology, Trondheim, Norway
Ait-Aissa, Selim (författare)
National Institute for Industrial Environment and Risks, Verneuil en Halatte, France
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Bado-Nilles, Anne (författare)
National Institute for Industrial Environment and Risks, Verneuil en Halatte, France; Reims University, Reims, France
Balzamo, Stefania (författare)
Istituto Superiore per la Protezione e la Ricerca Ambientale (ISPRA), Rome, Italy
Baun, Anders (författare)
Department of Environmental Engineering,Technical University of Denmark, Kgs Lyngby, Denmark
Belkin, Shimshon (författare)
Institute of Life Sciences, The Hebrew University, Jerusalem, Israel
Blaha, Ludek (författare)
Faculty of Science, RECETOX, Masaryk University, Brno, Czech Republic
Brion, Francois (författare)
National Institute for Industrial Environment and Risks, Verneuil en Halatte, France
Conti, Daniela (författare)
Istituto Superiore per la Protezione e la Ricerca Ambientale (ISPRA), Rome, Italy
Creusot, Nicolas (författare)
National Institute for Industrial Environment and Risks, Verneuil en Halatte, France
Essig, Yona (författare)
Analytical and Environmental Sciences Division, King's College, London, UK
Ferrero, Valentina E. V. (författare)
European Commission-DG Joint Research Centre, Institute for Environment and Sustainability, Ispra, Italy
Flander-Putrle, Vesna (författare)
Marine Biology Station Piran, National Institute of Biology, Ljubljana, Slovenia
Furhacker, Maria (författare)
University of Natural Resources and Life Sciences, Vienna, Austria
Grillari-Voglauer, Regina (författare)
University of Natural Resources and Life Sciences, Vienna, Austria
Hogstrand, Christer (författare)
Diabetes and Nutritional Sciences Division, King's College London, London, UK
Jonas, Adam (författare)
Faculty of Science, RECETOX, Masaryk University, Brno, Czech Republic
Kharlyngdoh, Joubert B., 1982- (författare)
Örebro universitet,Institutionen för naturvetenskap och teknik
Loos, Robert (författare)
European Commission-DG Joint Research Centre, Institute for Environment and Sustainability, Ispra, Italy
Lundebye, Anne-Katrine (författare)
National Institute of Nutrition and Seafood Research, Bergen, Norway
Modig, Carina, 1963- (författare)
Örebro universitet,Institutionen för naturvetenskap och teknik,Life Science Center, Örebro University, Örebro, Sweden
Olsson, Per-Erik, 1957- (författare)
Örebro universitet,Institutionen för naturvetenskap och teknik,Life Science Center, Örebro University, Örebro, Sweden
Pillai, Smitha (författare)
University of Natural Resources and Life Sciences, Vienna, Austria
Polak, Natasa (författare)
Analytical and Environmental Sciences Division, King's College, London, UK
Potalivo, Monica (författare)
Istituto Superiore per la Protezione e la Ricerca Ambientale (ISPRA), Rome, Italy
Sanchez, Wilfried (författare)
National Institute for Industrial Environment and Risks, Verneuil en Halatte, France
Schifferli, Andrea (författare)
Swiss Centre for Applied Ecotoxicology, Eawag-EPFL, Dübendorf, Switzerland
Schirmer, Kristin (författare)
Swiss Centre for Applied Ecotoxicology, Eawag-EPFL, Dübendorf, Switzerland
Sforzini, Susanna (författare)
Department of Environmental and Life Sciences, Universita del Piemonte Orientale Vercelli Novara Alessandria, Alessandria, Italy
Sturzenbaum, Stephen R. (författare)
Analytical and Environmental Sciences Division, King's College, London, UK
Søfteland, Liv (författare)
National Institute of Nutrition and Seafood Research, Bergen, Norway
Turk, Valentina (författare)
Marine Biology Station Piran, National Institute of Biology, Ljubljana, Slovenia
Viarengo, Aldo (författare)
Department of Environmental and Life Sciences, Università del Piemonte Orientale Vercelli Novara Alessandria, Alessandria, Italy
Werner, Inge (författare)
Swiss Centre for Applied Ecotoxicology, Swiss Federal Institute of Aquatic Science and Technology ( Eawag-EPFL), Dübendorf, Switzerland
Yagur-Kroll, Sharon (författare)
Institute of Life Sciences, The Hebrew University, Jerusalem, Israel
Zounkova, Radka (författare)
Faculty of Science, RECETOX, Masaryk University, Brno, Czech Republic
Lettieri, Teresa (författare)
European Commission-DG Joint Research Centre, Institute for Environment and Sustainability, Rome, Italy
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 (creator_code:org_t)
2014-09-12
2014
Engelska.
Ingår i: Toxicological Sciences. - : Oxford University Press (OUP). - 1096-6080 .- 1096-0929. ; 141:1, s. 218-233
Relaterad länk:
https://academic.oup...
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https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • The risk posed by complex chemical mixtures in the environment to wildlife and humans is increasingly debated, but has been rarely tested under environmentally relevant scenarios. To address this issue, two mixtures of 14 or 19 substances of concern (pesticides, pharmaceuticals, heavy metals, polyaromatic hydrocarbons, a surfactant, and a plasticizer), each present at its safety limit concentration imposed by the European legislation, were prepared and tested for their toxic effects. The effects of the mixtures were assessed in 35 bioassays, based on 11 organisms representing different trophic levels. A consortium of 16 laboratories was involved in performing the bioassays. The mixtures elicited quantifiable toxic effects on some of the test systems employed, including i) changes in marine microbial composition, ii) microalgae toxicity, iii) immobilization in the crustacean Daphnia magna, iv) fish embryo toxicity, v) impaired frog embryo development, and vi) increased expression on oxidative stress-linked reporter genes. Estrogenic activity close to regulatory safety limit concentrations was uncovered by receptor-binding assays. The results highlight the need of precautionary actions on the assessment of chemical mixtures even in cases where individual toxicants are present at seemingly harmless concentrations.

Ämnesord

NATURVETENSKAP  -- Geovetenskap och miljövetenskap -- Miljövetenskap (hsv//swe)
NATURAL SCIENCES  -- Earth and Related Environmental Sciences -- Environmental Sciences (hsv//eng)

Nyckelord

bioassays
effects
mixtures
ecotoxicology
biomarkers
Enviromental Science
Miljövetenskap

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

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