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Träfflista för sökning "WFRF:(Blasco J) srt2:(2005-2009)"

Sökning: WFRF:(Blasco J) > (2005-2009)

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1.
  • Espada, J, et al. (författare)
  • Nuclear envelope defects cause stem cell dysfunction in premature-aging mice
  • 2008
  • Ingår i: The Journal of cell biology. - : Rockefeller University Press. - 1540-8140 .- 0021-9525. ; 181:1, s. 27-35
  • Tidskriftsartikel (refereegranskat)abstract
    • Nuclear lamina alterations occur in physiological aging and in premature aging syndromes. Because aging is also associated with abnormal stem cell homeostasis, we hypothesize that nuclear envelope alterations could have an important impact on stem cell compartments. To evaluate this hypothesis, we examined the number and functional competence of stem cells in Zmpste24-null progeroid mice, which exhibit nuclear lamina defects. We show that Zmpste24 deficiency causes an alteration in the number and proliferative capacity of epidermal stem cells. These changes are associated with an aberrant nuclear architecture of bulge cells and an increase in apoptosis of their supporting cells in the hair bulb region. These alterations are rescued in Zmpste24−/−Lmna+/− mutant mice, which do not manifest progeroid symptoms. We also report that molecular signaling pathways implicated in the regulation of stem cell behavior, such as Wnt and microphthalmia transcription factor, are altered in Zmpste24−/− mice. These findings establish a link between age-related nuclear envelope defects and stem cell dysfunction.
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2.
  • Badía, J. D., et al. (författare)
  • A thermogravimetric approach to study the influence of a biodegradation in soil test to a Poly(lactic acid)
  • 2008
  • Ingår i: Macromolecular Symposia. - : Wiley. - 1022-1360 .- 1521-3900. ; 272:1, s. 93-99
  • Tidskriftsartikel (refereegranskat)abstract
    • An amorphous grade Poly (lactic acid) (PLA) was selected for an accelerated burial in soil test during 450 days. Thermogravimetric analyses were carried out to study the effects of degradation in soil on the thermal stability and the thermal decomposition kinetics. A single stage decomposition process is observed for all degradation times. It is shown that the thermal stability of PLA is slightly affected by degradation in soil. Concerning the study of the thermal decomposition kinetics, Criado master curves were plotted from experimental data to focus the study of the thermodegradation kinetic model.The kinetic methods proposed by Broido and Chang were used to calculate the apparent activation energies (Ea) of the degradation mechanism. These results were compared to the Ea values obtained by the method developed by Coats and Redfern in order to prove the applicability of the former methods to the kinetic study. As expected, non-linear tendency is found out for Ea variation along the degradation times, which can be explained as an evolution by stages. Copyright © 2008 WILEY-VCH Verlag GmbH & Co. KGaA.
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  • Resultat 1-4 av 4

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