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Plasma Aβ42/40 rati...
Plasma Aβ42/40 ratio alone or combined with FDG-PET can accurately predict amyloid-PET positivity: a cross-sectional analysis from the AB255 Study
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Perez-Grijalba, V (author)
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Arbizu, J (author)
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Romero, J (author)
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Prieto, E (author)
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Pesini, P (author)
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Sarasa, L (author)
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Guillen, F (author)
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Monleon, I (author)
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San-Jose, I (author)
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Martinez-Lage, P (author)
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Munuera, J (author)
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Hernandez, I (author)
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Buendia, M (author)
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Sotolongo-Grau, O (author)
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Alegret, M (author)
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Ruiz, A (author)
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Tarraga, L (author)
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Boada, M (author)
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Sarasa, M (author)
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Goni, M (author)
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Pujadas, F (author)
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Villarejo, A (author)
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Frank, A (author)
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Pena-Casanova, J (author)
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Fernandez, M (author)
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Pinol, G (author)
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Blesa, R (author)
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Gil, P (author)
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Pascual, LF (author)
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Aguilar, M (author)
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Frisoni, GB (author)
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Matias-Guiu, J (author)
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Andreasen, N (author)
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Antunez, C (author)
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- 2019-12-01
- 2019
- English.
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In: Alzheimer's research & therapy. - : Springer Science and Business Media LLC. - 1758-9193. ; 11:1, s. 96-
- Related links:
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https://alzres.biome...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- BackgroundTo facilitate population screening and clinical trials of disease-modifying therapies for Alzheimer’s disease, supportive biomarker information is necessary. This study was aimed to investigate the association of plasma amyloid-beta (Aβ) levels with the presence of pathological accumulation of Aβ in the brain measured by amyloid-PET. Both plasma Aβ42/40 ratio alone or combined with an FDG-PET-based biomarker of neurodegeneration were assessed as potential AD biomarkers.MethodsWe included 39 cognitively normal subjects and 20 patients with mild cognitive impairment from the AB255 Study who had undergone PiB-PET scans. Total Aβ40 and Aβ42 levels in plasma (TP42/40) were quantified using ABtest kits. Subjects were dichotomized as Aβ-PET positive or negative, and the ability of TP42/40 to detect Aβ-PET positivity was assessed by logistic regression and receiver operating characteristic analyses. Combination of plasma Aβ biomarkers and FDG-PET was further assessed as an improvement for brain amyloidosis detection and diagnosis classification.ResultsEighteen (30.5%) subjects were Aβ-PET positive. TP42/40 ratio alone identified Aβ-PET status with an area under the curve (AUC) of 0.881 (95% confidence interval [CI] = 0.779–0.982). Discriminating performance of TP42/40 to detect Aβ-PET-positive subjects yielded sensitivity and specificity values at Youden’s cutoff of 77.8% and 87.5%, respectively, with a positive predictive value of 0.732 and negative predictive value of 0.900. All these parameters improved after adjusting the model for significant covariates. Applying TP42/40 as the first screening tool in a sequential diagnostic work-up would reduce the number of Aβ-PET scans by 64%. Combination of both FDG-PET scores and plasma Aβ biomarkers was found to be the most accurate Aβ-PET predictor, with an AUC of 0.965 (95% CI = 0.913–0.100).ConclusionsPlasma TP42/40 ratio showed a relevant and significant potential as a screening tool to identify brain Aβ positivity in preclinical and prodromal stages of Alzheimer’s disease.
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- art (subject category)
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- By the author/editor
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Perez-Grijalba, ...
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Arbizu, J
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Romero, J
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Prieto, E
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Pesini, P
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Sarasa, L
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show more...
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Guillen, F
-
Monleon, I
-
San-Jose, I
-
Martinez-Lage, P
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Munuera, J
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Hernandez, I
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Buendia, M
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Sotolongo-Grau, ...
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Alegret, M
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Ruiz, A
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Tarraga, L
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Boada, M
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Sarasa, M
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Goni, M
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Pujadas, F
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Villarejo, A
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Frank, A
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Pena-Casanova, J
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Fernandez, M
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Pinol, G
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Blesa, R
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Gil, P
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Pascual, LF
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Aguilar, M
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Frisoni, GB
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Matias-Guiu, J
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Andreasen, N
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Antunez, C
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show less...
- Articles in the publication
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Alzheimer's rese ...
- By the university
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Karolinska Institutet