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- Murari, A., et al.
(författare)
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Measuring the radiation field and radiation hard detectors at JET : Recent developments
- 2008
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Ingår i: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier BV. - 0168-9002 .- 1872-9576. ; 593:3, s. 492-504
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Tidskriftsartikel (refereegranskat)abstract
- Since in ITER the radiation field will be much more demanding than that of present day devices, research programmes at JET are aimed at developing radiation hard diagnostics and related components. Initially, significant efforts are devoted to determining the radiation field of both the plasma and in the immediate environment with better accuracy. New developments in MCNP calculations and dedicated measurements provide useful information about the radiation field in the Torus Hall, even during non-operational periods. The effect of using Beryllium in the near future for JET first wall, is being assessed. New materials for activation samples are under consideration and will be tested to improve the calibration accuracy of JET neutron diagnostics. The long-term goal of this work is to obtain spectrometric information from an appropriate combination of different materials. Several studies are under way to modify the radiation field at the detectors by using LiH or pure water as neutron filters, to alleviate the problem of the background in gamma-ray measurements. A suite of radiation hard detectors for neutrons, magnetic field and charged particles are being developed. Super-heated fluid neutron detectors, used for yield and imaging, are being upgraded, in order to provide a broadband spectrometric capability. Chemical vapour deposited diamond diodes are being qualified as counters and as spectrometers. Prototypes of Hall probes made of InSb have been installed on the machine and have provided some preliminary results. Si-on-insulator detectors are under development for use in neutral particle analysers and are currently being bench-tested. Some attention is being devoted to optical components, fibres and mirrors, and to investigating radiation hard electronics using reconfigurable Field Programmable Gate Arrays.
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| 2. |
- Babakov, V.N., et al.
(författare)
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RelA/NF-?B transcription factor associates with a-actinin-4
- 2008
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Ingår i: Experimental Cell Research. - : Elsevier BV. - 0014-4827 .- 1090-2422. ; 314:5, s. 1030-1038
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Tidskriftsartikel (refereegranskat)abstract
- The NF-?B/RelA family of transcription factors regulates inducible transcription of a large number of genes in response to diverse stimuli. Little is known, however, about the location of NF-?B in the cytoplasm and the transport mechanism to the nucleus. We found that NF-?B is associated with the actin-binding protein a-actinin-4. NF-?B and a-actinin-4 co-localized along actin stress fibers and in membrane lamellae in A431 cells. After a 30-min stimulation with EGF or TNF-a, a-actinin-4 and p65 were found in the nucleus. Disruption of cytoskeleton by cytochalasin D prior to treatment with TNF-a led to increase of p65 nuclear translocation. Antibodies to p65 subunit of NF-?B co-immunoprecipitated a-actinin-4 from A431 cell lysates and nuclear extracts, but a-actinin-1 and ß-actin were not found in the precipitates. Affinity chromatography experiments displayed that p65 and p50 subunits of NF-?B can bind to matrix-bound chicken gizzard a-actinin. We suggest that the a-actinin-4 is important for the NF-?B nuclear translocation and its functions inside the nucleus. © 2007 Elsevier Inc. All rights reserved.
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