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- El-Nour, H., et al.
(författare)
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Galanin expression in a murine model of allergic contact dermatitis
- 2004
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Ingår i: Acta Dermato-Venereologica. - : Medical Journals Sweden AB. - 0001-5555 .- 1651-2057. ; 84:6, s. 428-432
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Tidskriftsartikel (refereegranskat)abstract
- Galanin is a neuropeptide widely distributed in the nervous system. The expression of galanin was investigated in murine contact allergy using immunohistochemistry, radioimmunoassay and in situ hybridization. Female BALB/c mice were sensitized with oxazolone and 6 days later challenged on the dorsal surface of ears, while control mice received vehicle. After 24 h, one ear was processed for immunostaining using a biotinylated fluorescence technique, while the other ear was frozen and processed for radioimmunoassay or in situ hybridization. Galanin immunoreactive nerve fibres were more numerous (p < 0.01) in the eczematous compared with control ears. Double-staining with antibody to the nerve fibre marker PGP (protein gene product) 9.5 revealed co-localization of PGP 9.5 and galanin in nerve fibres. Radioimmunoassay demonstrated a decrease (p < 0.04) in galanin concentration in eczematous compared with control ears. Our results suggest a role for galanin in murine contact allergy.
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| 3. |
- Elihn, Kristina, et al.
(författare)
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Size distributions and synthesis of nanoparticles by photolytic dissociation of ferrocene
- 2001
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Ingår i: APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING. - 0947-8396. ; 72:1, s. 29-34
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Tidskriftsartikel (refereegranskat)abstract
- Iran-containing nanoparticles were made by laser-assisted (ArF excimer laser, lambda = 193 nm) photolytic dissociation of ferrocene (Fe(C5H5)(2) or FeCp2) in argon and an oxygen/argon gas mixture. The particle-size distributions were obtained on-line by u
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| 7. |
- Olsen, M. H., et al.
(författare)
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Effect of losartan versus atenolol on aortic valve sclerosis (a LIFE substudy)
- 2004
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Ingår i: Am J Cardiol. - : Elsevier BV. - 0002-9149. ; 94:8, s. 1076-80
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Tidskriftsartikel (refereegranskat)abstract
- Neither losartan- nor atenolol-based antihypertensive regimens could prevent the progression of aortic valve (AV) sclerosis in elderly, high-risk hypertensive patients, and the regression of AV sclerosis did not translate into reduced cardiovascular risk.
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| 8. |
- Pedersen, Thomas, et al.
(författare)
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Origin invariant calculation of optical rotation without recourse to London orbitals
- 2004
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Ingår i: Chemical Physics Letters. - : Elsevier BV. - 0009-2614. ; 393:4-6, s. 319-326
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Tidskriftsartikel (refereegranskat)abstract
- We propose an inherently origin invariant formulation of specific optical rotation obtained from the conventional velocity gauge expression by subtracting the static limit from the electric dipole-magnetic dipole polarizability: <<(p) over right arrow, (L) over right arrow >>(omega) --> <<(p) over right arrow, (L) over right arrow >>(omega) - <<(p) over right arrow, (L) over right arrow >>(0). London (gauge including) atomic orbitals are therefore not needed to ensure origin invariance and, consequently, this modified velocity gauge formulation may be employed in conjunction with variational and non-variational quantum chemical methods alike. Sample calculations on S-propylene oxide and 3,4-methylenedioxymethamphetamine using self-consistent field and coupled cluster wave functions underline this point and show that the basis set convergence of the modified velocity gauge formulation is similar to the conventional length gauge and London expressions. (C) 2004 Elsevier B.V. All rights reserved.
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| 10. |
- Rosenberg, Per, et al.
(författare)
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Randomized trial of single agent paclitaxel given weekly versus every three weeks and with peroral versus intravenous steroid premedication to patients with ovarian cancer previously treated with platinum
- 2002
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Ingår i: Acta Oncologica. - : Informa UK Limited. - 0284-186X .- 1651-226X. ; 41:5, s. 418-424
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to evaluate the efficacy and toxicity of paclitaxel given at the same dose intensity and administered weekly (arm A) or every 3 weeks (arm B), and to assess the safety of intravenous steroids versus standard peroral premedication. Two hundred and eight patients with advanced ovarian cancer previously treated with no more than one platinum-containing regimen were randomized to receive either a weekly infusion of paclitaxel or an infusion every 3 weeks. The median delivered dose intensity was 77.6 mg/m2/week in the weekly arm, and 72.7 mg/m2/week in the every 3 weeks arm. WHO grade 3-4 hematological and non-hematological toxicity occurred more frequently in arm B. No difference in number of severe events of hypersensitivity, response rate, time to progression or survival between arms was observed. Weekly paclitaxel at a dose of 67 mg/m2/week was found to have a better safety profile and seemed to be as effective as the equivalently dosed schedule every 3 weeks. Intravenous steroids are a safe alternative to oral steroids.
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