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Träfflista för sökning "WFRF:(Boman H.) srt2:(2005-2009)"

Search: WFRF:(Boman H.) > (2005-2009)

  • Result 1-10 of 21
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  • Skar, H., et al. (author)
  • Multiple HIV-1 introductions into the Swedish intravenous drug user population
  • 2008
  • In: Infection, Genetics and Evolution. - : Elsevier BV. - 1567-1348 .- 1567-7257. ; 8:5, s. 545-552
  • Journal article (peer-reviewed)abstract
    • In 2001, an increase of HIV-1 diagnoses among intravenous drug users (IVDU) was reported in Sweden. In nearby countries, Finland, Russia and the Baltic states, recent outbreaks had been described. Since there was a concern that these outbreaks would carry over to Sweden a study was initiated to determine the factors leading to the Swedish increase of HIV-1 diagnosed IVDUs. HIV-1 env V3 sequences were obtained from 97 patients enrolled in ongoing epidemiological studies encompassing the years 1987-2004 with a focus on 2001-2002. The sequences were used for maximum likelihood and Bayesian inference of the molecular epidemiology. Among the virus spreading in 2001-2002, we found that four different subtypes/CRFs were present in the Swedish IVDU population (A, B, CRF01_AE and CRF06_cpx). Subtype B constituted 85% of the infections, established by 12 independent introductions into the IVDU population. The worrisome increase in 2001 was mainly not a result of import of the outbreaks in nearby countries, but rather a higher detection rate of secondary cases due to efficient epidemiological tracing of the generally slow spread of established forms of subtype B in the IVDU community. However, a few of the non-subtype B cases were linked to the outbreaks in Finland, Estonia and Latvia. Because HIV-1 outbreaks can easily be exported from one country to another amongst IVDUs, this prompts continued surveillance in the Baltic Sea Region.
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  • Boman, K., et al. (author)
  • Effects of carvedilol or metoprolol on PAI-1, tPA-mass concentration or Von Willebrand factor in chronic heart failure - a COMET substudy
  • 2009
  • In: Thrombosis Research. - 1879-2472. ; 125:2, s. 46-50
  • Journal article (peer-reviewed)abstract
    • INTRODUCTION: In COMET (Carvedilol or Metoprolol European Trial), carvedilol reduced mortality compared with metoprolol in patients with chronic heart failure. We hypothesized that carvedilol might have greater effects on endothelial derived haemostatic factors than metoprolol. We aimed to study the effects of carvedilol or metoprolol on tissue plasminogen activator (tPA), its inhibitor PAI-1 and Von Willebrand factor (VWF) in patients with heart failure. MATERIAL AND METHODS: We recruited 260 patients (134 on carvedilol, 126 on metoprolol), mean age 66 years and 84% of them men. Plasma mass concentrations of tPA and PAI-1and percent of VWF were measured at baseline and after one and two years of treatment. RESULTS: Plasma tPA, PAI-1 and VWF were similar between treatment groups at baseline and no significant differences between groups emerged after one or two years of treatment. In paired analyses in patients assigned to carvedilol, median PAI-1 level decreased from 37.2 to 32.1 microg/l at two years (p=0.034) and of VWF decreased from baseline to one year (240 vs. 218%, p=0.023) in patients assigned to carvedilol but were not reduced at any time in patients assigned to metoprolol. Plasma tPA increased over time in both treatment groups (p=0.013 and 0.027 respectively). CONCLUSION: We found no significant difference in the effects of carvedilol or metoprolol on tPA, PAI-1 and VWF. Comparison over time within treatment groups suggested that PAI-1 and VWF might have declined on carvedilol but not on metoprolol. Our hypothesis is not proved but this may reflect an inadequate sample size rather than lack of an effect.
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  • Result 1-10 of 21
Type of publication
conference paper (11)
journal article (8)
reports (1)
book chapter (1)
Type of content
other academic/artistic (13)
peer-reviewed (8)
Author/Editor
Boman, K. (6)
Boman, A (6)
El-Nour, H (5)
Nordlind, K (4)
Holst, M (3)
Enochsson, L (2)
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Gronlund, H (2)
Frostegard, J (2)
de Faire, U (2)
Hallmans, G (2)
Beck, O (2)
Wikstrom, M (2)
Albert, J. (1)
Hasegawa, S. (1)
Magnusson, P (1)
Nemitz, E. (1)
Hagström, Magnus, 19 ... (1)
Swedberg, Karl, 1944 (1)
Larsson, H (1)
Johansson, C. (1)
Englund, A (1)
Torkvist, L (1)
Boman, Johan, 1955 (1)
Andersson, H. (1)
Tornvall, P (1)
Rosenqvist, M (1)
Arnelo, U (1)
Lichtenstein, P. (1)
Liden, C (1)
Kjellman, B (1)
Thomas, R (1)
Theodorsson, E (1)
Romelsjö, Anders (1)
Andersson, Patrik U, ... (1)
Leitner, T (1)
Nilsson, T (1)
Yttri, Karl Espen (1)
Ljungström, Evert, 1 ... (1)
Theodorsson, Elvar, ... (1)
Andersen, KE (1)
Boman, C. (1)
Hansson, Hans Bertil (1)
Pettersson, Jan B. C ... (1)
Langer, Sarka, 1960 (1)
Sylvan, S (1)
Hallquist, Mattias, ... (1)
Janhäll, Sara, 1965- (1)
Cleland, J. G. (1)
Öhman, Marcus (1)
Boström, D (1)
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University
Karolinska Institutet (13)
Linköping University (3)
University of Gothenburg (2)
Umeå University (2)
Stockholm University (2)
Lund University (2)
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Luleå University of Technology (1)
Örebro University (1)
Chalmers University of Technology (1)
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Language
English (19)
Swedish (2)
Research subject (UKÄ/SCB)
Medical and Health Sciences (3)
Natural sciences (1)
Engineering and Technology (1)
Social Sciences (1)

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