| 1. |
- Boberg, Julia, et al.
(författare)
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Swedish multimodal cohort of patients with anxiety or depression treated with internet-delivered psychotherapy (MULTI-PSYCH)
- 2023
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Ingår i: BMJ Open. - : BMJ Publishing Group Ltd. - 2044-6055. ; 13:10
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Tidskriftsartikel (refereegranskat)abstract
- Purpose Depression and anxiety afflict millions worldwide causing considerable disability. MULTI-PSYCH is a longitudinal cohort of genotyped and phenotyped individuals with depression or anxiety disorders who have undergone highly structured internet-based cognitive-behaviour therapy (ICBT). The overarching purpose of MULTI-PSYCH is to improve risk stratification, outcome prediction and secondary preventive interventions. MULTI-PSYCH is a precision medicine initiative that combines clinical, genetic and nationwide register data.Participants MULTI-PSYCH includes 2668 clinically well-characterised adults with major depressive disorder (MDD) (n=1300), social anxiety disorder (n=640) or panic disorder (n=728) assessed before, during and after 12 weeks of ICBT at the internet psychiatry clinic in Stockholm, Sweden. All patients have been blood sampled and genotyped. Clinical and genetic data have been linked to several Swedish registers containing a wide range of variables from patient birth up to 10 years after the end of ICBT. These variable types include perinatal complications, school grades, psychiatric and somatic comorbidity, dispensed medications, medical interventions and diagnoses, healthcare and social benefits, demographics, income and more. Long-term follow-up data will be collected through 2029.Findings to date Initial uses of MULTI-PSYCH include the discovery of an association between PRS for autism spectrum disorder and response to ICBT, the development of a machine learning model for baseline prediction of remission status after ICBT in MDD and data contributions to genome wide association studies for ICBT outcome. Other projects have been launched or are in the planning phase.Future plans The MULTI-PSYCH cohort provides a unique infrastructure to study not only predictors or short-term treatment outcomes, but also longer term medical and socioeconomic outcomes in patients treated with ICBT for depression or anxiety. MULTI-PSYCH is well positioned for research collaboration.
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| 2. |
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It was forever until it was not : bachelor of fine arts 2022
- 2022
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Annan publikation (populärvet., debatt m.m.)abstract
- The exhibition is the culmination of three years of concentrated study in fine arts and presents a wide range of ideas and expressions. Building on their specific interests and personalities, these artists have developed works that reflect the present and the diversity represented by art in society today.The exhibition presents degree projects by students from the fine arts undergraduate programme at Umeå University's Academy of Fine Arts: Amira Al-Rayes, Juni Liv Uma, Ida Boman, Josefine Borgström, Simon H. Danielsson, Jonna Iversen, William Jernberg, Miranda Monauti, Viktor Nilsson, Kajsa Poidnak, Janina Renström, Moa Ryman, Savannah Sundström, and Catja Tonberg.
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| 3. |
- Shaltout, Abdallah A., et al.
(författare)
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Elemental Composition of PM2.5 Aerosol in a Residential–Industrial Area of a Mediterranean Megacity
- 2020
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Ingår i: Archives of Environmental Contamination and Toxicology. - : Springer Science and Business Media LLC. - 0090-4341 .- 1432-0703. ; 78, s. 68-78
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Tidskriftsartikel (refereegranskat)abstract
- Very little is known about the elemental composition and possible sources of fine aerosol particles from Mediterranean megacities. Fine aerosol particles were collected at a residential-industrial area in Greater Cairo, Egypt, during the period from October 2010 to May 2011. The elemental compositions of the collected samples were quantified by using a homemade energy dispersive x-ray fluorescence spectrometer, whereas black carbon was quantified by a black smoke detector. Fifteen elements have been quantified. Of these constituents, Ca, C, Cl, S, and Fe had the highest concentrations: greater than 1µgm−3. The overall mean mass concentration of the collected samples equals 70µgm−3; this value exceeds the European Union annual Air Quality Standard levels. The individual elemental concentrations of the fine particles were found to be dominated by elements linked to mineral dust. Most of the monthly variations of elemental concentrations can be attributed to seasonal meteorological conditions. Other possible sources were vehicle-exhaust and industrial activities. The results pinpoint the problem of identifying different sources when one source, in this case, the nearby deserts, is dominant. The results from this study contribute to the growing knowledge of concentrations, composition, and possible sources of ambient fine particulate matter. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.
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| 4. |
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| 5. |
- Bernhardsson, Susanne, 1958, et al.
(författare)
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Implementation of physical activity on prescription for children with obesity in paediatric health care (IMPA): protocol for a feasibility and evaluation study using quantitative and qualitative methods
- 2022
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Ingår i: Pilot and Feasibility Studies. - : Springer Science and Business Media LLC. - 2055-5784. ; 8:1
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Tidskriftsartikel (refereegranskat)abstract
- Background: Physical inactivity is a main cause of childhood obesity which tracks into adulthood obesity, making it important to address early in life. Physical activity on prescription (PAP) is an evidence-based intervention that has shown good effect on physical activity levels in adults, but has not been evaluated in children with obesity. This project aims to evaluate the prerequisites, determinants, and feasibility of implementing PAP adapted to children with obesity and to explore children's, parents', and healthcare providers' experiences of PAP. Methods: In the first phase of the project, healthcare providers and managers from 26 paediatric clinics in Region Vastra Gotaland, Sweden, will be invited to participate in a web-based survey and a subset of this sample for a focus group study. Findings from these two data collections will form the basis for adaptation of PAP to the target group and context. In a second phase, this adapted PAP intervention will be evaluated in a clinical study in a sample of approximately 60 children with obesity (ISO-BMI > 30) between 6 and 12 years of age and one of their parents/legal guardians. Implementation process and clinical outcomes will be assessed pre- and post-intervention and at 8 and 12 months' follow-up. Implementation outcomes are the four core constructs of the Normalization Process Theory; coherence, cognitive participation, collective action, and reflexive monitoring; and appropriateness, acceptability, and feasibility of the PAP intervention. Additional implementation process outcomes are recruitment and attrition rates, intervention fidelity, dose, and adherence. Clinical outcomes are physical activity pattern, BMI, metabolic risk factors, health-related quality of life, sleep, and self-efficacy and motivation for physical activity. Lastly, we will explore the perspectives of children and parents in semi-structured interviews. Design and analysis of the included studies are guided by the Normalization Process Theory. Discussion: This project will provide new knowledge regarding the feasibility of PAP for children with obesity and about whether and how an evidence-based intervention can be fitted and adapted to new contexts and populations. The results may inform a larger scale trial and future implementation and may enhance the role of PAP in the management of obesity in paediatric health care in Sweden.
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| 6. |
- Hirvikoski, T., et al.
(författare)
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Individual risk and familial liability for suicide attempt and suicide in autism : a population-based study
- 2020
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Ingår i: Psychological Medicine. - : Cambridge University Press. - 0033-2917 .- 1469-8978. ; 50:9, s. 1463-1474
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Studies on the individual gender-specific risk and familial co-aggregation of suicidal behaviour in autism spectrum disorder (ASD) are lacking.METHODS: We conducted a matched case-cohort study applying conditional logistic regression models on 54 168 individuals recorded in 1987-2013 with ASD in Swedish national registers: ASD without ID n = 43 570 (out of which n = 19035, 43.69% with ADHD); ASD + ID n = 10 598 (out of which n = 2894 individuals, 27.31% with ADHD), and 270 840 controls, as well as 347 155 relatives of individuals with ASD and 1 735 775 control relatives.RESULTS: The risk for suicidal behaviours [reported as odds ratio OR (95% confidence interval CI)] was most increased in the ASD without ID group with comorbid ADHD [suicide attempt 7.25 (6.79-7.73); most severe attempts i.e. requiring inpatient stay 12.37 (11.33-13.52); suicide 13.09 (8.54-20.08)]. The risk was also increased in ASD + ID group [all suicide attempts 2.60 (2.31-2.92); inpatient only 3.45 (2.96-4.02); suicide 2.31 (1.16-4.57)]. Females with ASD without ID had generally higher risk for suicidal behaviours than males, while both genders had highest risk in the case of comorbid ADHD [females, suicide attempts 10.27 (9.27-11.37); inpatient only 13.42 (11.87-15.18); suicide 14.26 (6.03-33.72); males, suicide attempts 5.55 (5.10-6.05); inpatient only 11.33 (9.98-12.86); suicide 12.72 (7.77-20.82)]. Adjustment for psychiatric comorbidity attenuated the risk estimates. In comparison to controls, relatives of individuals with ASD also had an increased risk of suicidal behaviour.CONCLUSIONS: Clinicians treating patients with ASD should be vigilant for suicidal behaviour and consider treatment of psychiatric comorbidity.
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| 7. |
- Mersal, G. A. M., et al.
(författare)
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Study of half metallic ferromagnetism and thermoelectric properties of spinel chalcogenides BaCr2X4 (X 1/4 S, Se, Te) for spintronic and energy harvesting
- 2022
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Ingår i: Journal of Materials Research and Technology-Jmr&T. - : Elsevier BV. - 2238-7854. ; 18:May–June 2022, s. 2831-2841
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Tidskriftsartikel (refereegranskat)abstract
- The control of spin degree of freedom in electronics open new horizons to manipulate, transfer, and storage data at fasters speed. For this the structural, electronic, and magnetic characteristics of BaCr2X4 (X 1/4 S, Se, Te) spinels are addressed comprehensively. The more energy release in ferromagnetic states than antiferromagnetic states, and formation energy verified thermal stability in FM states. The Curie temperature, and spin polarization density have been reported for room temperature ferromagnetism. The detail and nature of ferromagnetism have illustrated by band structures, density of states, hybridization, double exchange mechanism, crystal field energy, exchange energies and exchange constants. The transfer of magnetic moment from Cr sites to other nonmagnetic sites (Ba, X)
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| 8. |
- Rapezzi, Claudio, et al.
(författare)
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Efficacy of Tafamidis in Patients With Hereditary and Wild-Type Transthyretin Amyloid Cardiomyopathy : Further Analyses From ATTR-ACT
- 2021
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Ingår i: JACC. Heart failure. - : Elsevier. - 2213-1779 .- 2213-1787. ; 9:2, s. 115-123
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Tidskriftsartikel (refereegranskat)abstract
- Objectives: Tafamidis is an effective treatment for transthyretin amyloid cardiomyopathy (ATTR-CM), this study aimed to determine whether there is a differential effect between variant transthyretin amyloidosis (ATTRv) and wild-type transthyretin (ATTRwt).Background: ATTR-CM is a progressive, fatal disorder resulting from mutations in the ATTRv or the deposition of denatured ATTRwt.Methods: In pre-specified analyses from ATTR-ACT (Tafamidis in Transthyretin Cardiomyopathy Clinical Trial), baseline characteristics, all-cause mortality, and change from baseline to month 30 in 6-min walk test distance and Kansas City Cardiomyopathy Questionnaire Overall Summary score were compared in patients with ATTRwt and ATTRv.Results: There were 335 patients with ATTRwt (201 tafamidis, 134 placebo) and 106 with ATTRv (63 tafamidis, 43 placebo) enrolled in ATTR-ACT. Patients with ATTRwt (vs. ATTRv) had less advanced disease at baseline and a lower rate of disease progression over the study. The reduction in all-cause mortality with tafamidis compared with placebo was not different between ATTRwt (hazard ratio: 0.706 [95% confidence interval (CI): 0.474 to 1.052]; p = 0.0875) and ATTRv (hazard ratio: 0.690 [95% CI: 0.408 to 1.167]; p = 0.1667). Tafamidis was associated with a similar reduction (vs. placebo) in the decline in 6-min walk test distance in ATTRwt (mean ± SE difference from placebo, 77.14 ± 10.78; p < 0.0001) and ATTRv (79.61 ± 29.83 m; p = 0.008); and Kansas City Cardiomyopathy Questionnaire Overall Summary score in ATTRwt (12.72 ± 2.10; p < 0.0001) and ATTRv (18.18 ± 7.75; p = 0.019).Conclusions: Pre-specified analyses from ATTR-ACT confirm the poor prognosis of untreated ATTRv-related cardiomyopathy compared with ATTRwt, but show the reduction in mortality and functional decline with tafamidis treatment is similar in both disease subtypes. (Safety and Efficacy of Tafamidis in Patients With Transthyretin Cardiomyopathy [ATTR-ACT]; NCT01994889)
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| 9. |
- Shaltout, A. A., et al.
(författare)
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Environmental and health risks of potentially toxic elements in ambient PM10in Jeddah, Saudi Arabia
- 2024
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Ingår i: INTERNATIONAL JOURNAL OF ENVIRONMENTAL SCIENCE AND TECHNOLOGY. - 1735-1472 .- 1735-2630.
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Tidskriftsartikel (refereegranskat)abstract
- Source apportionment and environmental and risk assessments of ambient PM10 collected from three locations in Jeddah, Saudi Arabia, were investigated. These estimations were based on the concentrations of ambient PM10 mass and potentially toxic elements. The annual ambient PM10 concentration, 120 +/- 40, 180 +/- 170, and 150 +/- 230 mu g/m(3) at three locations respectively, exceeds the Saudi Arabia annual air quality limit (80 mu g/m(3)). The highest 24-h PM10 concentrations were measured at a location influenced by traffic and industries (1800 mu g/m(3)) and at a seaside location (2000 mu g/m(3)) while the lowest 24-h PM10 concentration was measured at a university campus site (50 mu g/m(3)). The elements As, Cd, Ce, Co, Cr, Mn, Mo, Ni, Pb, Sb, Se, Sn, Te, V, and Zn were included in the source apportionment analysis using positive matrix factorization. The major sources identified were crustal material and windblown dust (27-28%), a mix of natural and anthropogenic sources (20-26%), combustion and traffic (18-21%), industrial activities (14-20%), and heavy metal industry (11-15%). Several environmental risk indices show a serious environmental pollution problem in Jeddah city due to the high concentrations of ambient PM10 and their elemental content. A non-carcinogenic health risk assessment showed that Cd and Mn constituted a risk for children and adults and inhalation was the main pathway for exposure. No carcinogenic risks were found but Cd, Co, and Ni had CR values above the safe limit of 10(-6).
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| 10. |
- Shaltout, A. A., et al.
(författare)
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Temporal and Spatial Variations of Potentially Toxic Elements in PM10 Collected in Jeddah City, Saudi Arabia
- 2023
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Ingår i: Archives of Environmental Contamination and Toxicology. - 0090-4341. ; 85:4, s. 451-65
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Tidskriftsartikel (refereegranskat)abstract
- Air pollution causes environmental and health problems around the world. In this study, ambient particulate matter with an aerodynamic diameter equal to or less than 10 microns (PM10) has been collected at three different locations in Jeddah city, Saudi Arabia. The locations are characterized by differences in terms of traffic, residential intensity, industrial, and non-road mobile machinery activities. The monthly and annual mass concentration of the PM10 exceeds the recommended annual limit of the World Health Organization (15 & mu;g/m(3)) and the European air quality standard (40 & mu;g/m(3)) at the three locations. The collected PM10 samples as well as a certified reference material of atmospheric particulates (NIST 1678a) were digested in aqua regia using microwave digestion. The quantitative elemental analysis was carried out using inductively coupled plasma mass spectrometry. The variations of the elemental concentration in terms of workdays, weekends, seasons, and annual were determined at the three locations. The spatial and temporal elemental variations were found to be different between the three sites, pointing to local influences that should be further evaluated. The concentration of Cd was found to be high and may cause health problems.
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