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Proviral integratio...
Proviral integrations and expression of endogenous Avian leucosis virus during long term selection for high and low body weight in two chicken lines
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- Ka, Sojeong, 1976- (författare)
- Uppsala universitet,Medicinsk utvecklingsbiologi,Hallböök group
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- Kerje, Susanne (författare)
- Uppsala universitet,Institutionen för neurovetenskap,Institutionen för medicinska vetenskaper,Institutionen för medicinsk biokemi och mikrobiologi,Autoimmuna sjukdomar
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- Bomold, Lina (författare)
- Uppsala universitet,Institutionen för neurovetenskap
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- Liljegren, Ulrika (författare)
- Uppsala universitet,Institutionen för neurovetenskap
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Siegel, P. B. (författare)
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- Andersson, Leif (författare)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Institutionen för husdjursgenetik (HGEN),Department of Animal Breeding and Genetics
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- Hallböök, Finn (författare)
- Uppsala universitet,Medicinsk utvecklingsbiologi
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(creator_code:org_t)
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- 2009-07-15
- 2009
- Engelska.
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Ingår i: Retrovirology. - : Springer Science and Business Media LLC. - 1742-4690. ; 6, s. 68-
- Relaterad länk:
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https://retrovirolog...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://res.slu.se/i...
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Abstract
Ämnesord
Stäng
- Background:Long-term selection (> 45 generations) for low or high juvenile body weight from a common founder population of White Plymouth Rock chickens has generated two extremely divergent lines, the LWS and HWS lines. In addition to a > 9-fold difference between lines for the selected trait, large behavioural and metabolic differences between the two lines evolved during the course of the selection. We recently compared gene expression in brain tissue from birds representing these lines using a global cDNA array analysis and the results showed multiple but small expression differences in protein coding genes. The main differentially expressed transcripts were endogenous retroviral sequences identified as avian leucosis virus subgroup-E (ALVE). Results: In this work we confirm the differential ALVE expression and analysed expression and number of proviral integrations in the two parental lines as well as in F-9 individuals from an advanced intercross of the lines. Correlation analysis between expression, proviral integrations and body weight showed that high ALVE levels in the LWS line were inherited and that more ALVE integrations were detected in LWS than HWS birds.Conclusion:We conclude that only a few of the integrations contribute to the high expression levels seen in the LWS line and that high ALVE expression was significantly correlated with lower body weights for the females but not males. The conserved correlation between high expression and low body weight in females after 9 generations of intercrosses, indicated that ALVE loci conferring high expression directly affects growth or are very closely linked to loci regulating growth.
Ämnesord
- LANTBRUKSVETENSKAPER -- Veterinärmedicin (hsv//swe)
- AGRICULTURAL SCIENCES -- Veterinary Science (hsv//eng)
- LANTBRUKSVETENSKAPER -- Husdjursvetenskap (hsv//swe)
- AGRICULTURAL SCIENCES -- Animal and Dairy Sience (hsv//eng)
Nyckelord
- MEDICINE
- MEDICIN
- Developmental Neurosciences
- Medicinsk utvecklings- och neurobiologi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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