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Unexpected Fat Dist...
Unexpected Fat Distribution in Adolescents With Narcolepsy
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- Morales Drissi, Natasha (författare)
- Linköpings universitet,Avdelningen för radiologiska vetenskaper,Medicinska fakulteten
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- Romu, Thobias (författare)
- Linköpings universitet,Institutionen för medicinsk teknik,Tekniska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,AMRA Med AB, Linkoping, Sweden
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- Landtblom, Anne-Marie (författare)
- Linköpings universitet,Uppsala universitet,Neurologi,Center for Medical Image Science and Visualization, Linköping University, Linköping, Sweden; Department of Clinical and Experimental Medicine (IKE), Linköping University, Linköping, Sweden,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Region Östergötland, Neurologiska kliniken i Linköping,Uppsala Univ, Sweden
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- Szakacs, A. (författare)
- Univ Gothenburg, Sweden
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- Hallböök, Tove (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,Univ Gothenburg, Sweden
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- Darin, Niklas, 1964 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,Univ Gothenburg, Sweden
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- Borga, Magnus (författare)
- Linköpings universitet,Avdelningen för medicinsk teknik,Tekniska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,AMRA Med AB, Linkoping, Sweden
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- Dahlqvist Leinhard, Olof, 1978- (författare)
- Linköpings universitet,Avdelningen för radiologiska vetenskaper,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Region Östergötland, Radiofysikavdelningen US,AMRA Med AB, Linkoping, Sweden
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- Engström, Maria (författare)
- Linköpings universitet,Avdelningen för radiologiska vetenskaper,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV
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(creator_code:org_t)
- 2018-12-06
- 2018
- Engelska.
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Ingår i: Frontiers in Endocrinology. - : Frontiers Media SA. - 1664-2392. ; 9
- Relaterad länk:
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https://www.frontier...
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https://doi.org/10.3...
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https://liu.diva-por... (primary) (Raw object)
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https://gup.ub.gu.se...
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https://doi.org/10.3...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Narcolepsy type 1 is a chronic sleep disorder with significantly higher BMI reported in more than 50% of adolescent patients, putting them at a higher risk for metabolic syndrome in adulthood. Although well-documented, the body fat distribution and mechanisms behind weight gain in narcolepsy are still not fully understood but may be related to the loss of orexin associated with the disease. Orexin has been linked to the regulation of brown adipose tissue (BAT), a metabolically active fat involved in energy homeostasis. Previous studies have used BMI and waist circumference to characterize adipose tissue increases in narcolepsy but none have investigated its specific distribution. Here, we examine adipose tissue distribution in 19 adolescent patients with narcolepsy type 1 and compare them to 17 of their healthy peers using full body magnetic resonance imaging (MRI). In line with previous findings we saw that the narcolepsy patients had more overall fat than the healthy controls, but contrary to our expectations there were no group differences in supraclavicular BAT, suggesting that orexin may have no effect at all on BAT, at least under thermoneutral conditions. Also, in line with previous reports, we observed that patients had more total abdominal adipose tissue (TAAT), however, we found that they had a lower ratio between visceral adipose tissue (VAT) and TAAT indicating a relative increase of subcutaneous abdominal adipose tissue (ASAT). This relationship between VAT and ASAT has been associated with a lower risk for metabolic disease. We conclude that while weight gain in adolescents with narcolepsy matches that of central obesity, the lower VAT ratio may suggest a lower risk of developing metabolic disease.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- orexin
- hypocretin
- brown adipose tissue
- visceral adipose tissue
- subcutaneous adipose tissue
- BMI
- brown adipose-tissue
- metabolic risk-factors
- body-mass index
- cold-exposure
- visceral fat
- hypothalamic-lesions
- energy-expenditure
- insulin-resistance
- genetic ablation
- orexin neurons
- BMI
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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