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| 2. |
- Mavaddat, N, et al.
(författare)
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Risk-reducing salpingo-oophorectomy, natural menopause, and breast cancer risk: an international prospective cohort of BRCA1 and BRCA2 mutation carriers
- 2020
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Ingår i: Breast cancer research : BCR. - : Springer Science and Business Media LLC. - 1465-542X. ; 22:1, s. 8-
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundThe effect of risk-reducing salpingo-oophorectomy (RRSO) on breast cancer risk forBRCA1andBRCA2mutation carriers is uncertain. Retrospective analyses have suggested a protective effect but may be substantially biased. Prospective studies have had limited power, particularly forBRCA2mutation carriers. Further, previous studies have not considered the effect of RRSO in the context of natural menopause.MethodsA multi-centre prospective cohort of 2272BRCA1and 1605BRCA2mutation carriers was followed for a mean of 5.4 and 4.9 years, respectively; 426 women developed incident breast cancer. RRSO was modelled as a time-dependent covariate in Cox regression, and its effect assessed in premenopausal and postmenopausal women.ResultsThere was no association between RRSO and breast cancer forBRCA1(HR = 1.23; 95% CI 0.94–1.61) orBRCA2(HR = 0.88; 95% CI 0.62–1.24) mutation carriers. ForBRCA2mutation carriers, HRs were 0.68 (95% CI 0.40–1.15) and 1.07 (95% CI 0.69–1.64) for RRSO carried out before or after age 45 years, respectively. The HR forBRCA2mutation carriers decreased with increasing time since RRSO (HR = 0.51; 95% CI 0.26–0.99 for 5 years or longer after RRSO). Estimates for premenopausal women were similar.ConclusionWe found no evidence that RRSO reduces breast cancer risk forBRCA1mutation carriers. A potentially beneficial effect forBRCA2mutation carriers was observed, particularly after 5 years following RRSO. These results may inform counselling and management of carriers with respect to RRSO.
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| 3. |
- Xie, G., et al.
(författare)
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Virtual Test Method of Structure-Borne Sound for a Metro Bogie
- 2021
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Ingår i: Notes on Numerical Fluid Mechanics and Multidisciplinary Design. - Cham : Springer Science and Business Media Deutschland GmbH. ; , s. 186-193
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Konferensbidrag (refereegranskat)abstract
- This paper presents a virtual test method for structure-borne noise generated from railway running gear. This method combines a number of existing tools to form a system approach. The wheelset and bogie frame are modelled using FEM software Nastran to include details of their construction. The primary springs are simplified to standard CBUSH elements in Nastran with point and transfer stiffness modelled by frequency-dependent complex stiffness, which are tuned against measurements. The wheel-rail contact forces due to roughness excitation are obtained by the wheel-rail interaction tool TWINS. The vibration of the full running gear is simulated in Nastran by applying the wheel-rail contact forces. The forces transmitted to the vehicle body through traction bars and dampers are calculated for predicting structure-borne noise.
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| 4. |
- de Muynck, Ldan, et al.
(författare)
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Consensus Statement on the Use of Near-Infrared Fluorescence Imaging during Pancreatic Cancer Surgery Based on a Delphi Study: Surgeons' Perspectives on Current Use and Future Recommendations
- 2023
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Ingår i: Cancers. - : MDPI AG. - 2072-6694. ; 15:3
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Tidskriftsartikel (refereegranskat)abstract
- Simple Summary Despite the potential of fluorescence imaging during pancreatic cancer surgery, more research is needed to facilitate the approval of tumor-targeted probes, standardize imaging techniques, and most importantly, gain trust from surgeons. Despite advancements in the development of novel probes, preclinical research settings do not always accurately represent the surgical setting. This first-of-its-kind Delphi consensus survey highlights current experiences and attitudes towards fluorescence imaging during pancreatic cancer surgery, specifically from surgeon's perspectives. The results from this consensus survey highlight potential new directions for future research, which could facilitate the standardized use of fluorescence imaging during pancreatic surgery. Indocyanine green (ICG) is one of the only clinically approved near-infrared (NIR) fluorophores used during fluorescence-guided surgery (FGS), but it lacks tumor specificity for pancreatic ductal adenocarcinoma (PDAC). Several tumor-targeted fluorescent probes have been evaluated in PDAC patients, yet no uniformity or consensus exists among the surgical community on the current and future needs of FGS during PDAC surgery. In this first-published consensus report on FGS for PDAC, expert opinions were gathered on current use and future recommendations from surgeons' perspectives. A Delphi survey was conducted among international FGS experts via Google Forms. Experts were asked to anonymously vote on 76 statements, with >= 70% agreement considered consensus and >= 80% participation/statement considered vote robustness. Consensus was reached for 61/76 statements. All statements were considered robust. All experts agreed that FGS is safe with few drawbacks during PDAC surgery, but that it should not yet be implemented routinely for tumor identification due to a lack of PDAC-specific NIR tracers and insufficient evidence proving FGS's benefit over standard methods. However, aside from tumor imaging, surgeons suggest they would benefit from visualizing vasculature and surrounding anatomy with ICG during PDAC surgery. Future research could also benefit from identifying neuroendocrine tumors. More research focusing on standardization and combining tumor identification and vital-structure imaging would greatly improve FGS's use during PDAC surgery.
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| 5. |
- Bjurling, Oscar, et al.
(författare)
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Enabling Human-Autonomy Teaming in Aviation : A Framework to Address Human Factors in Digital Assistants Design
- 2024
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Ingår i: Journal of Physics, Conference Series. - : Institute of Physics. - 1742-6588 .- 1742-6596. ; 2716
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Tidskriftsartikel (refereegranskat)abstract
- The introduction of artificial intelligence (AI) tools in aviation necessitates more research into human-autonomy teaming in these domain settings. This paper describes the development of a design framework for supporting Human Factors novices in considering human factors, improving human-autonomy collaboration, and maintaining safety when developing AI tools for aviation settings. Combining elements of Hierarchical Task Analysis, Coactive Design, and Types and Levels of Autonomy, the design framework provides guidance in three phases: modelling and understanding the existing system and associated tasks; producing a new function allocation for optimal Human-Autonomy Teaming (HAT); and assessing HAT-related risks of the proposed design. In this framework, designers generate a comprehensive set of design considerations to support subsequent development processes. Framework limitations and future research avenues are discussed.
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| 7. |
- Rodriguez-Fernandez, N., et al.
(författare)
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Paving the Road to Flex and Biomass : The Land Surface Carbon Constellation Study
- 2022
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Ingår i: IGARSS 2022 - 2022 IEEE International Geoscience and Remote Sensing Symposium. - 9781665427920 ; 2022-July, s. 5571-5574
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Konferensbidrag (refereegranskat)abstract
- Remote sensing observations of variables related to vegetation at microwave and optical/infrared wavelengths are presented over three regions in Europe in the Iberian peninsula, northern Finland and central Europe. They include the instrumented sites of Las Majadas, Sodankyla and Reusel. The final goal is to better constrain land carbon cycle models using the complementarities of vegetation optical depth derived at different frequencies from active and passive instruments (related to vegetation water content and biomass) as well as optical data of the fraction of absorbed photosynthetically active radiation or solar induced fluorescence, closely linked to photosynthesis. The first results confirm this complementarity. For instance, time series of different variables exhibit positive correlations in some areas and negative correlations in other areas.
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