| 1. |
- Alm, P., et al.
(author)
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Immunoglobulin-A producing probably primary lymphoma of the breast
- 1983
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In: Virchows Archiv. - 1432-2307. ; 399:3, s. 355-360
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Journal article (peer-reviewed)abstract
- A breast tumour from a 65-year old woman was found to be a primary non-Hodgkin lymphoma, a very rare primary malignancy in this location. The lymphoma was of a diffuse histiocytic type according to the classification of Rappaport, or polymorphic immunocytoma according to the Kiel classification. Immunohistochemistry, not previously reported for breast lymphomas, revealed the production of IgA. In the serum this appeared as an IgA M-component which was greatly reduced after tumour removal. Immunological properties of primary breast lymphomas are reviewed, we suggest further extended studies with the immunohistochemical use of marker substances for the evaluation of prognosis. © 1983 Springer-Verlag.
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| 2. |
- Brandt, L., et al.
(author)
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Uptake of thymidine in lymphoma cells obtained through fine-needle aspiration biopsy. Relation to prognosis in non-hodgkin's lymphomas
- 1981
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In: European Journal of Cancer and Clinical Oncology. - 0277-5379. ; 17:11, s. 1229-1233
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Journal article (peer-reviewed)abstract
- In vitro uptake of tritiated thymidine was studied in autoradiographic preparations of lymphoma cell suspensions obtained through fine-needle aspiration biopsy from 28 patients with non-Hodgkin's lymphoma. The labelling indices (LI ) were highest in patients with histiocytic or poorly differentiated lymphocytic lymphoma. During a two-year period there was a significant correlation between LI and survival, i.e., high LI were associated with a poor prognosis. The results indicate that, in addition to morphology, estimation of the proliferative activity of lymphoma cells may be of clinical significance. © 1981, Pergamon Press Ltd.. All rights reserved.
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| 3. |
- Monti, M., et al.
(author)
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Metabolic Activity of Lymphoma Cells and Clinical Course in Non‐Hodgkin Lymphoma (NHL)
- 1981
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In: Scandinavian Journal of Haematology. - : Wiley. - 1600-0609 .- 0036-553X. ; 27:5, s. 305-310
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Journal article (peer-reviewed)abstract
- By microcalorimetry the metabolic activity of malignant cells from 21 patients with non‐Hodgkin lymphoma was monitored. Heat production, a measure of the metabolic activity of cells, showed positive correlation with the clinical‐course of the disease. The heat produced by tumor cells from patients with progressive disease was 5.5 pW/cell, while that from patients responding to treatment was 3.1 pW/cell. The difference between the 2 groups is significant (P <0.05). A higher heat production was obtained in tumor cells from 7 out of 10 patients who were unresponsive to the therapy when compared with cells from 11 patients who had become asymptomatic as a result of the same therapy. Also heat production from blood lymphocytes was found to be higher (P <0.005) in the group of patients with progressive disease as compared to the group of patients who responded to therapy. The present results indicate an association between high heat production in lymphoma cells and blood lymphocytes and a poor prognosis. © Munksgaard 1981
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| 4. |
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| 5. |
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| 6. |
- Olsson, H., et al.
(author)
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Occupational exposure to organic solvents and Hogdkin's disease in man. A case-referent study
- 1980
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In: Scandinavian Journal of Work, Environment and Health. - : Scandinavian Journal of Work, Environment and Health. - 0355-3140 .- 1795-990X. ; 6:4, s. 302-305
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Journal article (peer-reviewed)abstract
- A standardized personal interview schedule was used to study occupational exposure to organic solvents among 25 men aged 20-65 a with Hodgkin's disease and 50 referents matched for sex, age and residence. When exposure was defined as the handling of organic solvents every workday for at least 1 a within the 10-a period immediately preceding the interview, 12 of the Hodgkin's disease patients (48%) and six referents (12%) were occupationally exposed with a relative risk of 6.6 (p = 0.0005). For 9 of the 12 exposed Hodgkin's disease patients exposure to aromatic solvents was verified, and such exposure may well have occurred for the remaining three patients also. It was concluded that exposure to organic solvents may constitute an occupational risk with regard to Hodgkin's disease.
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| 7. |
- Olsson, H., et al.
(author)
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Relation between age of mothers with breast cancer and sex of their children
- 1980
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In: British Medical Journal. - : BMJ. - 0959-8146. ; 281:6247, s. 1029-1031
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Journal article (peer-reviewed)abstract
- In a consecutive series of 150 women with breast cancer 122 had borne one or more children. Sixty-two patients were aged below 55 years at diagnosis (group A) and 60 were 55 years or older (group B). In group A 91 out of 153 children (59%) were boys compared with 48 out of 141 (34%) in group B (p=0 000007). In group A 54 of the 62 patients (87%) had given birth to one or more boys compared with 35 of the 60 (58%) in group B (p=0 0003). The mean age at diagnosis in mothers of two or more boys was 49 0 years, in those of one boy 55-2 years, and in those of only girls 61 0 years. The differences between each of the mean ages was significant. The mean age at diagnosis in 28 nulliparous patients was 57-7 years. There was no significant correlation between the number of female pregnancies and age at diagnosis. These results suggest that in women liable to develop breast cancer male pregnancies are associated with an early onset of the disease. © 1980, British Medical Journal Publishing Group. All rights reserved.
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| 8. |
- Olsson, Håkan, et al.
(author)
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Sex Ratio in Offspring of Patients with Non-Hodgkin Lymphoma
- 1982
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In: New England Journal of Medicine. - 0028-4793. ; 306:6, s. 367-368
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Journal article (peer-reviewed)abstract
- To the Editor: In a letter in the November 5 issue, Alperovitch and Feingold reported an increased sex ratio (male:female) among children of women with multiple sclerosis.1 We have observed a remarkably decreased sex ratio in the offspring of young adults with non-Hodgkin lymphoma. We recorded the sex of the children of 197 patients with this disease who were participating in an epidemiologic study and obtained the same information from a control group of 240 patients without any evident malignant disease. Interviewing the control patients established that they had mainly cardiovascular or respiratory disorders. The results of this study are. © 1982, Massachusetts Medical Society. All rights reserved.
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| 9. |
- Olsson, H., et al.
(author)
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Supradiaphragmatic Presentation of Non‐Hodgkin's Lymphoma in Men Occupationally Exposed to Organic Solvents
- 1981
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In: Acta Medica Scandinavica. - : Wiley. - 0001-6101. ; 210:1-6, s. 415-418
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Journal article (peer-reviewed)abstract
- ABSTRACT. Using a standardized interview schedule, occupational exposure to organic solvents was investigated in 61 consecutive male patients with the diagnosis of non‐Hodgkin's lymphoma. When exposure was defined as handling of organic solvents every working day for at least one year, 23 patients were exposed and 38 non‐exposed. Of 15 patients with clinical stage I‐II above the diaphragm, 12 (80%) were occupationally exposed to organic solvents. Only 1 (11%) of 9 patients with clinical stage I‐II disease located below the diaphragm was exposed. Thirty‐seven patients had clinical stage III‐IV disease at the time of diagnosis and 10 (27%) of these were exposed. The predominance of exposed patients in the group with stage I‐II disease above the diaphragm is significant and the results indicate a relation between exposure to organic solvents and supradiaphragmatic presentation of non‐Hodgkin's lymphoma. No correlation was found between exposure and the morphology of the lymphomas. 1981 Association for the Publication of the Journal of Internal Medicine
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